Results 1 to 10 of about 75,057 (290)

The Role of Sphingolipids and Sphingosine-1-phosphate—Sphingosine-1-phosphate-receptor Signaling in Psoriasis [PDF]

Cells, 2023
Psoriasis is a long-lasting skin condition characterized by redness and thick silver scales on the skin’s surface. It involves various skin cells, including keratinocytes, dendritic cells, T lymphocytes, and neutrophils.
Kana Masuda-Kuroki, Shahrzad Alimohammadi, Anna Di Nardo   +2 more
doaj   +6 more sources

Sphingosine 1-Phosphate Receptor 1 Signaling in Mammalian Cells [PDF]

Molecules, 2017
The bioactive lipid, sphingosine 1-phosphate (S1P) binds to a family of G protein-coupled receptors, termed S1P1-S1P5. These receptors function in, for example, the cardiovascular system to regulate vascular barrier integrity and tone, the nervous system
Nigel J. Pyne, Susan Pyne
doaj   +6 more sources

Structural insights into sphingosine-1-phosphate receptor activation [PDF]

Proceedings of the National Academy of Sciences, 2022
As a critical sphingolipid metabolite, sphingosine-1-phosphate (S1P) plays an essential role in immune and vascular systems. There are five S1P receptors, designated as S1PR1-5, encoded in the human genome, and their activities are governed by endogenous
Leiye Yu, Licong He, Bing Gan, Rujuan Ti, Q. Xiao, Hongli Hu, Lizhe Zhu, Sheng Wang, R. Ren   +8 more
semanticscholar   +3 more sources

Sphingosine 1-phosphate receptor 1 regulates blood-brain barrier permeability in epileptic mice. [PDF]

Neural Regen Res, 2023
Destruction of the blood-brain barrier is a critical component of epilepsy pathology. Several studies have demonstrated that sphingosine 1-phosphate receptor 1 contributes to the modulation of vascular integrity.
Yang LX, Yao YY, Yang JR, Cheng HL, Zhu XJ, Zhang ZJ.   +5 more
europepmc   +2 more sources

Sphingosine 1-phosphate receptor modulators in multiple sclerosis treatment: A practical review. [PDF]

Ann Clin Transl Neurol
Four sphingosine 1‐phosphate (S1P) receptor modulators (fingolimod, ozanimod, ponesimod, and siponimod) are approved by the US Food and Drug Administration for the treatment of multiple sclerosis.
Coyle PK, Freedman MS, Cohen BA, Cree BAC, Markowitz CE.   +4 more
europepmc   +2 more sources

Fingolimod modulates microglial activation to augment markers of remyelination [PDF]

Journal of Neuroinflammation, 2011
Introduction Microglial activation in multiple sclerosis has been postulated to contribute to long-term neurodegeneration during disease. Fingolimod has been shown to impact on the relapsing remitting phase of disease by modulating autoreactive T-cell ...
Baker David, Giovannoni Gavin, Jackson Samuel J   +2 more
doaj   +5 more sources

Sphingosine 1-phosphate receptor 2 in keratinocytes plays a key role in reducing inflammation in psoriasis [PDF]

Frontiers in Immunology
BackgroundPsoriasis is an inflammatory skin condition where immune cells play a significant role. The importance of the cross-talk between keratinocytes and immune cells in the pathogenesis of psoriasis has recently been reaffirmed.
Kana Masuda-Kuroki, Shahrzad Alimohammadi, Samantha Lowry, Anna Di Nardo   +3 more
doaj   +2 more sources

Sphingosine-1-phosphate receptor 1/5 selective agonist alleviates ocular vascular pathologies [PDF]

Scientific Reports
Ocular abnormal angiogenesis and edema are featured in several ocular diseases. S1P signaling via S1P1 likely is part of the negative feedback mechanism necessary to maintain vascular health.
Shinsuke Nakamura, Rie Yamamoto, Takaya Matsuda, Hiroto Yasuda, Anri Nishinaka, Kei Takahashi, Yuki Inoue, Sadao Kuromitsu, Masamitsu Shimazawa, Masahide Goto, Shuh Narumiya, Hideaki Hara   +11 more
doaj   +2 more sources

Sphingosine 1-phosphate modulates antigen capture by murine langerhans cells via the S1P2 receptor subtype [PDF]

, 2012
Dendritic cells (DCs) play a pivotal role in the development of cutaneous contact hypersensitivity (CHS) and atopic dermatitis as they capture and process antigen and present it to T lymphocytes in the lymphoid organs.
A Kihara, A Kissenpfennig, A Kumar, A Martino, A Olivera, A Weigert, AD Christensen, Burkhard Kleuser, C Ocana-Morgner, C Ruedl, CC Norbury, CL Bennett, CL Bennett, DH Kaplan, DH Kaplan, E Guaguere, ES Trombetta, EY Seo, F Sparber, G Gollmann, G Schuhmachers, H Hackstein, H Liu, Heinfried H. Radeke, HH Radeke, I Reines, J Chun, Jagadeesh Bayry, JH Hong, K Kabashima, K Sarkar, K Takabe, Katrin Schaper, L Japtok, L Rose, L Ruwisch, LS Bursch, Lukasz Japtok, M Hara-Chikuma, M Matloubian, M Schröder, M Schuppel, MB Lutz, MC Kerr, ML Allende, ML Allende, N Romani, P Mitra, P Monti, R van de Ven, RH Kim, RM Steinman, S Spiegel, S Sullivan, S Xu, Se Kyoo Jeong, SH Wood, SP Zahner, T Hla, T Kitajima, T Walzer, V Brinkmann, W Baumer, W Baumer, W Baumer, Wolfgang Bäumer, Y Maeda, Y Yanagawa, YY Lan   +68 more
core   +12 more sources

Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants. [PDF]

PLoS ONE, 2011
Ovarian transplantation is one of the key approaches to restoring fertility in women who became menopausal as a result of cancer treatments. A major limitation of human ovarian transplants is massive follicular loss during revascularization.
Reza Soleimani, Elke Heytens, Kutluk Oktay   +2 more
doaj   +1 more source