Results 41 to 50 of about 75,057 (290)

Sphingosine 1-Phosphate Receptor 4 Expression in Colorectal Cancer Patients

Walailak Journal of Science and Technology, 2016
The aim of this study was to investigate the expression of S1PR4 in colorectal cancer and its correlation with clinicopathologic characteristics. Paraffin-embedded colorectal cancer samples and matched adjacent normal tissues were collected from 32 ...
Suchittra SAMUHASANEETO, Suthiporn PROMAGSORN, Chuchard PUNSAWAD   +2 more
doaj   +1 more source

Sphingosine Kinase 1 Signaling in Breast Cancer: A Potential Target to Tackle Breast Cancer Stem Cells

Frontiers in Molecular Biosciences, 2021
Sphingosine kinases (SPHKs) are conserved lipid enzymes that catalyze the formation of sphingosine-1-phosphate (S1P) through ATP-dependent phosphorylation of sphingosine.
Ling-Wei Hii, Ling-Wei Hii, Felicia Fei-Lei Chung, Chun-Wai Mai, Chun-Wai Mai, Pei Yuen Ng, Chee-Onn Leong, Chee-Onn Leong   +7 more
doaj   +1 more source

Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer [PDF]

Discover Oncology, 2021
AbstractSphingosine-1-phosphate (S1P), a pleiotropic lipid mediator, participates in various cellular processes during tumorigenesis, including cell proliferation, survival, drug resistance, metastasis, and angiogenesis. S1P is formed by two sphingosine kinases (SphKs), SphK1 and SphK2. The intracellularly produced S1P is delivered to the extracellular
Guangmeng Xu, Zecheng Yang, Yamin Sun, Hongmei Dong, Jingru Ma   +4 more
openaire   +3 more sources

In silico Docking Studies of Fingolimod and S1P1 Agonists

Frontiers in Pharmacology, 2020
The sphingosine-1-phosphate receptor 1 (S1P1), originally the endothelial differentiation gene 1 receptor (EDG-1), is one of five G protein–coupled receptors (GPCRs) S1P1–5 that bind to and are activated by sphingosine-1-phosphate (S1P). The lipid S1P is
Alexander Marciniak, Sara M. Camp, Joe G. N. Garcia, Robin Polt   +3 more
doaj   +1 more source

Feeding Stimulates Sphingosine-1-Phosphate Mobilization in Mouse Hypothalamus. [PDF]

, 2019
Previous studies have shown that the sphingolipid-derived mediator sphingosine-1-phosphate (S1P) reduces food intake by activating G protein-coupled S1P receptor-1 (S1PR1) in the hypothalamus.
Misto, Alessandra, Piomelli, Daniele, Realini, Natalia, Vozella, Valentina   +3 more
core   +1 more source

Sphingosine-1-phosphate receptor signalling in the heart [PDF]

Cardiovascular Research, 2008
The five known members of the sphingosine-1-phosphate (S1P) receptor family exhibit diverse tissue expression profiles and couple to distinct G-protein-mediated signalling pathways. S1P1, S1P2, and S1P3 receptors are all present in the heart, but the ratio of these subtypes differs for various cardiac cells. The goal of this review is to summarize data
Christopher K, Means, Joan Heller, Brown
openaire   +2 more sources

Circuit Integration Initiation of New Hippocampal Neurons in the Adult Brain

Cell Reports, 2020
Summary: In the adult brain, new dentate granule cells integrate into neural circuits and participate in hippocampal functioning. However, when and how they initiate this integration remain poorly understood. Using retroviral and live-imaging methods, we
Chih-Hao Yang, Adrian Di Antonio, Gregory W. Kirschen, Parul Varma, Jenny Hsieh, Shaoyu Ge   +5 more
doaj   +1 more source

Sphingosine-1-phosphate promotes the persistence of activated CD4 T cells in inflamed sites [PDF]

, 2017
Inflammation can be protective or pathogenic depending on context and timeframe. Acute inflammation, including the accumulation of CD4 T cells, accompanies protective immune responses to pathogens, but the presence of activated CD4 T cells at sites of ...
Ammit, Barnden, Brinkmann, Brown, Chimen, Cyster, Debes, Faust, Firestein, Fu, Garrod, Gibson, Han, Hochreiter-Hufford, Hugues, Jo, Karuppuchamy, Kitano, Ledgerwood, Liao, Limaye, Lindquist, Mackay, Mackay, Mammoto, Masopust, Matloubian, Matsuura, McInnes, Means, Mempel, Mendoza, Murphy, Nowarski, Olivera, Priceman, Pyne, Sawicka, Skon, Smith, Spangrude, Tarrason, Teijeira, Tsunemi, Veres, Wang, Wang   +46 more
core   +3 more sources

Antinociceptive activity of the S1P-receptor agonist FTY720 [PDF]

, 2008
FTY720 is a novel immunosuppressive drug that inhibits the egress of lymphocytes from secondary lymphoid tissues and thymus. In its phosphorylated form FTY720 is a potent S1P receptor agonist.
Angioni, Carlo Federico, Brenneis, Christian, Coste, Ovidiu, Geisslinger, Gerd, Marian, Claudiu, Pierre, Sandra, Popp, Laura, Schmidt, Helmut, Scholich, Klaus   +8 more
core   +1 more source

Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling

Journal of Lipid Research, 2009
The sphingolipid metabolite sphingosine-1-phosphate (S1P) and the kinases that produce it have emerged as critical regulators of numerous fundamental biological processes important for health and disease.
Michael Maceyka, Sheldon Milstien, Sarah Spiegel   +2 more
doaj   +1 more source