General mechanism of spider toxin family I acting on sodium channel Nav1.7. [PDF]
Zool Res, 2022 Various peptide toxins in animal venom inhibit voltage-gated sodium ion channel Nav1.7, including Nav-targeting spider toxin (NaSpTx) Family I. Toxins in NaSpTx Family I share a similar structure, i.e., N-terminal, loops 1–4, and C-terminal.
Yuan FC +6 more
europepmc +3 more sources
A Spider Toxin Exemplifies the Promises and Pitfalls of Cell-Free Protein Production for Venom Biodiscovery. [PDF]
Toxins (Basel), 2021 Arthropod venoms offer a promising resource for the discovery of novel bioactive peptides and proteins, but the limited size of most species translates into minuscule venom yields.
Lüddecke T +8 more
europepmc +4 more sources
A Novel Spider Toxin Inhibits Fast Inactivation of the Nav1.9 Channel by Binding to Domain III and Domain IV Voltage Sensors [PDF]
Frontiers in Pharmacology, 2021 Venomous animals have evolved to produce peptide toxins that modulate the activity of voltage-gated sodium (Nav) channels. These specific modulators are powerful probes for investigating the structural and functional features of Nav channels.
Shuijiao Peng +7 more
doaj +3 more sources
The Identification of a Novel Spider Toxin Peptide, Lycotoxin-Pa2a, with Antibacterial and Anti-Inflammatory Activities [PDF]
Antibiotics, 2023 With the increasing challenge of controlling infectious diseases due to the emergence of antibiotic-resistant strains, the importance of discovering new antimicrobial agents is rapidly increasing.
Min Kyoung Shin +8 more
doaj +3 more sources
Fast desensitization of acetylcholine receptors induced by a spider toxin. [PDF]
Channels (Austin), 2021 Nicotinic acetylcholine receptors (nAChRs) are members of the “cys-loop” ligand-gated ion channel superfamily that play important roles in both the peripheral and central system.
Pan NC, Zhang T, Hu S, Liu C, Wang Y.
europepmc +4 more sources
Variation of Two S3b Residues in KV4.1–4.3 Channels Underlies Their Different Modulations by Spider Toxin κ-LhTx-1 [PDF]
Frontiers in Pharmacology, 2021 The naturally occurred peptide toxins from animal venoms are valuable pharmacological tools in exploring the structure-function relationships of ion channels.
Zhen Xiao +7 more
doaj +3 more sources
The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells. [PDF]
Toxins (Basel), 2017 Spider venoms constitute incredibly diverse libraries of compounds, many of which are involved in prey capture and defence. Polyamines are often prevalent in the venom and target ionotropic glutamate receptors. Here we show that a novel spider polyamine,
Wilson D +10 more
europepmc +4 more sources
The Peptide PnPP-19, a Spider Toxin Derivative, Activates μ-Opioid Receptors and Modulates Calcium Channels [PDF]
Toxins, 2018 The synthetic peptide PnPP-19 comprehends 19 amino acid residues and it represents part of the primary structure of the toxin δ-CNTX-Pn1c (PnTx2-6), isolated from the venom of the spider Phoneutria nigriventer.
Ana C. N. Freitas +11 more
doaj +3 more sources
Effect of the spider toxin Tx3-3 on spinal processing of sensory information in naive and neuropathic rats: an in vivo electrophysiological study. [PDF]
Pain Rep, 2017 Introduction: Drugs that counteract nociceptive transmission in the spinal dorsal horn preferentially after nerve injury are being pursued as possible neuropathic pain treatments. In a previous behavioural study, the peptide toxin Tx3-3, which blocks P/Q-
Dalmolin GD +8 more
europepmc +3 more sources
Spider Toxin Peptide Lycosin-I Functionalized Gold Nanoparticles for in vivo Tumor Targeting and Therapy. [PDF]
Theranostics, 2017 Cell penetrating peptides (CPPs) are commonly utilized for intracellular delivery of functional materials to circumvent biomembrane barrier. However, further application of CPPs is hindered by lacking selectivity toward targeted cells.
Tan H +8 more
europepmc +4 more sources