Binding of Hanatoxin to the Voltage Sensor of Kv2.1
Toxins, 2012 Hanatoxin 1 (HaTx1) is a polypeptide toxin isolated from spider venoms. HaTx1 inhibits the voltage-gated potassium channel kv2.1 potently with nanomolar affinities. Its receptor site has been shown to contain the S3b-S4a paddle of the voltage sensor (VS).
Shin-Ho Chung, Anna Robinson, Rong Chen
doaj +1 more source
CSTX-1, a toxin from the venom of the hunting spider Cupiennius salei, is a selective blocker of L-type calcium channels in mammalian neurons [PDF]
, 2007 The inhibitor cystine-knot motif identified in the structure of CSTX-1 from Cupiennius salei venom suggests that this toxin may act as a blocker of ion channels.
Beirão, PSL +8 more
core +1 more source
Fast Tissue Clearing and Volume Imaging Techniques for Anatomy
Microscopy Research and Technique, EarlyView.Tissue clearing and volume imaging techniques have revolutionized our ability to visualize large biological samples, but they face obstacles related to speed, tissue preservation, complexity, and the need for fluorescence labels that make them difficult to implement in anatomy and preclinical research.
Clément Ricard +5 more
wiley +1 more source
The teneurin C-terminal domain possesses nuclease activity and is apoptogenic. [PDF]
, 2018 Teneurins are type 2 transmembrane proteins expressed by developing neurons during periods of synaptogenesis and apoptosis. Neurons expressing teneurin-1 synapse with other teneurin-1-expressing neurons, and neurons expressing teneurin-2 synapse with ...
Chiquet-Ehrismann, Ruth +2 more
core +3 more sources
Land Degradation &Development, Volume 36, Issue 5, Page 1564-1578, March 2025.ABSTRACT Intensified slash‐and‐burn cultivation and forest clearing have caused severe land degradation in the Khasi Hills (Meghalaya plateau, NE India). Despite very high annual rainfall, the region faces severe water scarcity during the dry season.
Bob W. Zwartendijk +5 more
wiley +1 more source
The role of surface water waves on cyanobacterial blooms in lakes
Limnology and Oceanography Letters, EarlyView.Abstract The biophysical processes by which wind‐driven surface waves influence cyanobacterial bloom formation, transport, aerosolization, and termination in lakes represent a major knowledge gap in our understanding of bloom dynamics. We synthesized the literature that examined how waves interact with cyanobacterial bloom processes including ...
Cale A. C. Gushulak +10 more
wiley +1 more source
Characterisation of novel insecticidal ion channel toxins from araneomorph and mygalomorph spider venoms [PDF]
, 2011 University of Technology, Sydney. Faculty of Science.The high potency and selectivity of various peptide neurotoxins within spider venoms means these toxins are being considered as leads for the development of new environmentally-benign biopesticides ...
Chong, Y
core
Spider venom administration impairs glioblastoma growth and modulates immune response in a non-clinical model. [PDF]
, 2020 Molecules from animal venoms are promising candidates for the development of new drugs. Previous in vitro studies have shown that the venom of the spider Phoneutria nigriventer (PnV) is a potential source of antineoplastic components with activity in ...
Barreto, Natália +12 more
core +1 more source
Protease inhibitors from marine venomous animals and their counterparts in terrestrial venomous animals [PDF]
, 2013 The Kunitz-type protease inhibitors are the best-characterized family of serine protease inhibitors, probably due to their abundance in several organisms.
Mourão, Caroline Barbosa Farias +1 more
core +3 more sources
Nanomaterial‐Integrated 3D Biofabricated Structures for Advanced Biomedical Applications
Macromolecular Materials and Engineering, EarlyView.This review investigates the integration of nanomaterials into 3D biofabricated structures, highlighting the potential in tissue regeneration, wound healing, and cancer therapy. It discusses key techniques, including bioprinting and electrospinning, while addressing challenges such as biocompatibility, scalability, and regulatory barriers.
Mustafijur Rahman +9 more
wiley +1 more source