Results 111 to 120 of about 356,161 (284)

Spider neurotoxins targeting voltage-gated sodium channels [PDF]

, 2005
The voltage-gated sodium (Nav) channel is a target for a number of drugs, insecticides, and neurotoxins. These bind to at least seven identified neurotoxin binding sites and either block conductance or modulate sodium channel gating and/or kinetics.
Little, MJ, Nicholson, GM
core   +1 more source

Design and Production of a Recombinant Hybrid Toxin to Raise Protective Antibodies against Loxosceles Spider Venom

Toxins, 2019
Human accidents with spiders of the genus Loxosceles are an important health problem affecting thousands of people worldwide. Patients evolve to severe local injuries and, in many cases, to systemic disturbances as acute renal failure, in which cases ...
P. A. Calabria, L. H. A. L. Shimokawa-Falcão, M. Colombini, A. Moura-da-Silva, K. Barbaro, E. Faquim-Mauro, G. S. Magalhães   +6 more
semanticscholar   +1 more source

Beyond mammals: the evolution of chewing and other forms of oropharyngeal food processing in vertebrates

Biological Reviews, EarlyView.
ABSTRACT Oropharyngeal food processing exhibits a remarkable diversity among vertebrates, reflecting the evolution of specialised ‘processing centres’ associated with the mandibular, hyoid, and branchial arches. Although studies have detailed various food‐processing strategies and mechanisms across vertebrates, a coherent and comprehensive terminology ...
Daniel Schwarz, Maja Mielke, Stephan Handschuh, Anthony Herrel, Patrick Lemell, Léa Da Cunha, Nicolai Konow   +6 more
wiley   +1 more source

Are ticks venomous animals? [PDF]

, 2017
[Introduction]: As an ecological adaptation venoms have evolved independently in several species of Metazoa. As haematophagous arthropods ticks are mainly considered as ectoparasites due to directly feeding on the skin of animal hosts. Ticks are of major
Cabezas-Cruz, Alejandro, Valdés, James J.   +1 more
core   +1 more source

From identification to functional characterization of cyriotoxin‐1a, an antinociceptive toxin from the spider Cyriopagopus schioedtei

British Journal of Pharmacology, 2019
The NaV1.7 channel is highly expressed in dorsal root ganglia of the sensory nervous system and plays a central role in the pain signalling process.
T. C. Gonçalves, É. Benoit, M. Kurz, Laetitia Lucarain, Sophie Fouconnier, Stéphanie Combemale, Lucie Jaquillard, B. Schombert, J. Chambard, R. Boukaiba, G. Hessler, A. Bohme, Laurent Bialy, Stéphane Hourcade, Rémy Béroud, M. De Waard, D. Servent, M. Partiseti   +17 more
semanticscholar   +1 more source

Tailoring Thermophysical Properties and Multiscale Machine Learning Modeling of 2D Nanomaterial‐Infused Beeswax as a Green NePCM for Sustainable Thermal Management Systems

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This study develops eco‐friendly two‐dimensional nanoparticle‐enhanced phase change materials (2D NePCMs) using biodegradable beeswax infused with rGO, GO, and MXene nanoparticles. Experimental results demonstrated up to 21.9% enhancement in thermal conductivity with minimal latent heat loss, while machine learning models achieved >95% predictive ...
Abdullah Aziz, Shoaib Anwer, Eiyad Abu‐Nada, Anas Alazzam   +3 more
wiley   +1 more source

Detection and identification of huwentoxin-IV interacting proteins by biotin-avidin chemistry combined with mass spectrometry

Journal of Venomous Animals and Toxins including Tropical Diseases, 2014
Background : Numerous spider toxins are of interest as tools for neurophysiological research or as lead molecules for the development of pharmaceuticals and insecticides.
Hai Yu, Hui Liu, Yizhong Yan, Zhigui Duan, Xianchun Wang   +4 more
doaj   +1 more source

Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2 [PDF]

, 2014
Mambalgins are a novel class of snake venom components that exert potent analgesic effects mediated through the inhibition of acid-sensing ion channels (ASICs). The 57-residue polypeptide mambalgin-2 (Ma-2) was synthesized by using a combination of solid-
Baconguis, Bang, Baron, Brünger, Craik, Dawson, Dawson, Deval, Diochot, Durek, Dutertre, Escoubas, Ghassemian, Güntert, Jensen, Kent, Kini, Morales, Poppe, Saez, Salinas, Schnölzer, Shen, Sherwood, Utkin, Wishart   +25 more
core   +1 more source

Health Benefits of Polysaccharides in Red Algae: A Comprehensive Review

Food Frontiers, EarlyView.
Graphical abstract showing the health benefits of red algal polysaccharides. ABSTRACT Humans have long consumed red algae (especially by the Asian community), and their polysaccharide extracts (carrageenan, agar) are extensively used in the food industry as gel thickeners.
Sammueal Jun Kai Ong, Matthew Myint, Sean Chia, Chee Fan Tan, Yi Fan Hong, Meiyappan Lakshmanan, Ying Swan Ho, Thomas T. Wheeler, Xuezhi Bi, Ian Walsh, Kuin Tian Pang   +10 more
wiley   +1 more source

Binding of Hanatoxin to the Voltage Sensor of Kv2.1

Toxins, 2012
Hanatoxin 1 (HaTx1) is a polypeptide toxin isolated from spider venoms. HaTx1 inhibits the voltage-gated potassium channel kv2.1 potently with nanomolar affinities. Its receptor site has been shown to contain the S3b-S4a paddle of the voltage sensor (VS).
Shin-Ho Chung, Anna Robinson, Rong Chen
doaj   +1 more source