Results 121 to 130 of about 356,161 (284)

Characterisation of novel insecticidal ion channel toxins from araneomorph and mygalomorph spider venoms [PDF]

, 2011
University of Technology, Sydney. Faculty of Science.The high potency and selectivity of various peptide neurotoxins within spider venoms means these toxins are being considered as leads for the development of new environmentally-benign biopesticides ...
Chong, Y
core  

Isorhamnetin Alleviates Renal Fibrosis Induced by Renal Tubular Epithelial Cell Senescence Via Inhibition of the IL‐6/IL‐6R Signaling Pathway

iMetaMed, EarlyView.
IL‐6 from RTECs upregulates TGF‐β in macrophages, promoting fibroblast transdifferentiation. Isorhamnetin inhibits this effect. ABSTRACT Chronic kidney disease (CKD) is a major global health issue. Kidney fibrosis is a key mechanism leading to end‐stage renal disease.
Weifei Liang, Xiangqiu Chen, Tao Wu, Xichun Zheng, Shaohua Zeng, Qingchun Zhou, Wen Ma, Hao Lin, Donglin Sun   +8 more
wiley   +1 more source

A Novel Hyaluronidase from Brown Spider (Loxosceles intermedia) Venom (Dietrich's Hyaluronidase): From Cloning to Functional Characterization [PDF]

, 2013
Loxoscelism is the designation given to clinical symptoms evoked by Loxosceles spider's bites. Clinical manifestations include skin necrosis with gravitational spreading and systemic disturbs. the venom contains several enzymatic toxins.
Chaim, Olga Meiri, Ferrer, Valeria Pereira, Gremski, Luiza Helena, Gremski, Waldemiro, Mari, Thiago Lopes de, Nader, Helena Bonciani, Senff-Ribeiro, Andrea, Silva, Dilza Trevisan, Silveira, Rafael Bertoni da, Veiga, Silvio Sanches   +9 more
core   +4 more sources

Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin

Cell, 2019
Hui Xu, Tianbo Li, A. Rohou, C. Arthur, Foteini Tzakoniati, Evera Wong, A. Estevez, Christine Kugel, Y. Franke, Jun Chen, C. Ciferri, D. Hackos, C. Koth, J. Payandeh   +13 more
semanticscholar   +3 more sources

Antinociceptive effect of PnTx4(5-5), a peptide from Phoneutria nigriventer spider venom, in rat models and the involvement of glutamatergic system

Journal of Venomous Animals and Toxins including Tropical Diseases
Background: The venom of Phoneutria nigriventer spider is a source of numerous bioactive substances, including some toxins active in insects. An example is PnTx4(5-5) that shows a high insecticidal activity and no apparent toxicity to mice, although it ...
Camila Franco Batista Oliveira, Daniela Pereira Alves, Bruna Luiza Emerich, Suely Gomes de Figueiredo, Marta do Nascimento Cordeiro, Márcia Helena Borges, Michael Richardson, Adriano Monteiro de Castro Pimenta, Igor Dimitri Gama Duarte, Maria Elena de Lima   +9 more
doaj   +1 more source

Novel gating mechanism of polyamine block in the strong inward rectifier K channel Kir2.1. [PDF]

, 1999
Inward rectifying K channels are essential for maintaining resting membrane potential and regulating excitability in many cell types. Previous studies have attributed the rectification properties of strong inward rectifiers such as Kir2.1 to voltage ...
John, SA, Lee, JK, Weiss, JN
core   +1 more source

Tissue-specific expression of calcium channels [PDF]

, 1993
The high-voltage-activated calcium channel is a multimeric protein complex containing 1, 2/δ, β, and γ subunits. The 1 subunit is the ion conduction channel and contains the binding sites for calcium channel blockers and toxins.
Biel, Biel, Bosse, Bosse, Catterall, Cavalié, Dascal, De Jongh, De Jongh, De Jongh, Diebold, Dubel, Ellis, Fleckenstein, Flockerzi, Glossmann, Guy, Hartzell, Heinemann, Hofmann, Hofmann, Hullin, Hymel, Jay, Jay, Kim, Kim, Klöckner, Lacerda, Mikami, Mintz, Mori, Mundiña-Weilenmann, Nakayama, Norman, Nunoki, Osterrieder, Perez-Reyes, Perez-Reyes, Pragnell, Regulla, Rotman, Ruth, Röhrkasten, Scino, Singer, Snutch, Striessnig, Striessnig, Tanabe, Tanabe, Tanabe, Tsien, Varadi, Wei, Welling, Welling, Williams, Williams, Yatani   +59 more
core   +1 more source

Animal toxins: what features differentiate pore blockers from gate modifiers [PDF]

, 2005
A surprisingly large number of animal toxins target voltage sensitive ion channels. Even though there exists toxins for all four major voltage sensitive ion channels, a majority act either on sodium or potassium channels.
Bhogal, S., Bhogal, S., Revett, K., Revett, K.   +3 more
core   +1 more source

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi

PLoS ONE, 2017
Spider venoms are rich sources of peptidic ion channel modulators with important therapeutical potential. We screened a panel of 60 spider venoms to find modulators of ion channels involved in pain transmission.
S. R. Sousa, Joshua S. Wingerd, A. Brust, C. Bladen, L. Ragnarsson, V. Herzig, J. Deuis, S. Dutertre, I. Vetter, G. Zamponi, G. King, P. Alewood, R. Lewis   +12 more
semanticscholar   +1 more source

High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain [PDF]

, 2007
Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
Abrahamsen, B, Bowden, S, Brust, A, Cesare, P, Colless, B, Drew, LJ, Gale, JE, Heinzmann, S, Lewis, RJ, Robinson, M, Rugiero, F, Wood, JN   +11 more
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