The Cystine Knot Is Responsible for the Exceptional Stability of the Insecticidal Spider Toxin ω-Hexatoxin-Hv1a [PDF]
Toxins, 2015 The inhibitor cystine knot (ICK) is an unusual three-disulfide architecture in which one of the disulfide bonds bisects a loop formed by the two other disulfide bridges and the intervening sections of the protein backbone.
Volker Herzig, Glenn F. King
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Purification and Characterization of a Novel Insecticidal Toxin, μ-sparatoxin-Hv2, from the Venom of the Spider Heteropoda venatoria [PDF]
Toxins, 2018 The venom of the spider Heteropoda venatoria produced lethal effect to cockroaches as reported in our previous study, and could be a resource for naturally-occurring insecticides.
Zhen Xiao +5 more
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PhTx3-4, a Spider Toxin Calcium Channel Blocker, Reduces NMDA-Induced Injury of the Retina [PDF]
Toxins, 2016 The in vivo neuroprotective effect of PhTx3-4, a spider toxin N-P/Q calcium channel blocker, was studied in a rat model of NMDA-induced injury of the retina. NMDA (N-Methyl-d-Aspartate)-induced retinal injury in rats reduced the b-wave amplitude by 62% ±
Nancy Scardua Binda +11 more
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First generation of multifunctional peptides derived from latarcin-3a from Lachesana tarabaevi spider toxin. [PDF]
Front Microbiol, 2022 The need for discovering new compounds that can act selectively on pathogens is becoming increasingly evident, given the number of deaths worldwide due to bacterial infections or tumor cells.
de Moraes LFRN +9 more
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Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNa V 1.7 and hCa V 3 voltage‐gated channels [PDF]
The FEBS Journal, 2023 Venom‐derived peptides targeting ion channels involved in pain are regarded as a promising alternative to current, and often ineffective, chronic pain treatments.
Julien Giribaldi +10 more
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Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes [PDF]
Frontiers in Pharmacology, 2023 The structure-function and optimization studies of NaV-inhibiting spider toxins have focused on developing selective inhibitors for peripheral pain-sensing NaV1.7.
Yashad Dongol +4 more
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A Proteomics and Transcriptomics Investigation of the Venom from the Barychelid Spider Trittame loki (Brush-Foot Trapdoor) [PDF]
Toxins, 2013 Although known for their potent venom and ability to prey upon both invertebrate and vertebrate species, the Barychelidae spider family has been entirely neglected by toxinologists. In striking contrast, the sister family Theraphosidae (commonly known as
Eivind A. B. Undheim +12 more
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SVM-based prediction of propeptide cleavage sites in spider toxins identifies toxin innovation in an Australian tarantula. [PDF]
PLoS ONE, 2013 Spider neurotoxins are commonly used as pharmacological tools and are a popular source of novel compounds with therapeutic and agrochemical potential.
Emily S W Wong +4 more
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In Silico-Based Design of a Hybrid Peptide with Antimicrobial Activity against Multidrug-Resistant Pseudomonas aeruginosa Using a Spider Toxin Peptide [PDF]
Toxins, 2023 The escalating prevalence of antibiotic-resistant bacteria poses an immediate and grave threat to public health. Antimicrobial peptides (AMPs) have gained significant attention as a promising alternative to conventional antibiotics.
Min Kyoung Shin +8 more
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Phα1β Spider Toxin Reverses Glial Structural Plasticity Upon Peripheral Inflammation. [PDF]
Front Cell Neurosci, 2019 The incoming signals from injured sensory neurons upon peripheral inflammation are processed in the dorsal horn of spinal cord, where glial cells accumulate and play a critical role in initiating allodynia (increased pain in response to light-touch ...
Tenza-Ferrer H +4 more
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