The Identification of a Novel Spider Toxin Peptide, Lycotoxin-Pa2a, with Antibacterial and Anti-Inflammatory Activities [PDF]
Antibiotics, 2023 With the increasing challenge of controlling infectious diseases due to the emergence of antibiotic-resistant strains, the importance of discovering new antimicrobial agents is rapidly increasing.
Min Kyoung Shin +8 more
doaj +2 more sources
Highlights in the knowledge of brown spider toxins [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2017 Brown spiders are venomous arthropods that use their venom for predation and defense. In humans, bites of these animals provoke injuries including dermonecrosis with gravitational spread of lesions, hematological abnormalities and impaired renal function.
Daniele Chaves-Moreira +5 more
doaj +5 more sources
Phase coupling of a circadian neuropeptide with rest/activity rhythms detected using a membrane-tethered spider toxin. [PDF]
PLoS Biology, 2008 Drosophila clock neurons are self-sustaining cellular oscillators that rely on negative transcriptional feedback to keep circadian time. Proper regulation of organismal rhythms of physiology and behavior requires coordination of the oscillations of ...
Ying Wu +4 more
doaj +3 more sources
The Cystine Knot Is Responsible for the Exceptional Stability of the Insecticidal Spider Toxin ω-Hexatoxin-Hv1a [PDF]
Toxins, 2015 The inhibitor cystine knot (ICK) is an unusual three-disulfide architecture in which one of the disulfide bonds bisects a loop formed by the two other disulfide bridges and the intervening sections of the protein backbone.
Volker Herzig, Glenn F. King
doaj +2 more sources
Sphingomyelinase D from Loxosceles laeta Venom Induces the Expression of MMP7 in Human Keratinocytes: Contribution to Dermonecrosis. [PDF]
PLoS ONE, 2016 Envenomation by Loxosceles spider is characterized by the development of dermonecrosis. In previous studies, we have demonstrated that increased expression/secretion of matrix metalloproteinases 2 and 9, induced by Loxosceles intermedia venom Class 2 ...
Mara A Corrêa +4 more
doaj +6 more sources
General mechanism of spider toxin family I acting on sodium channel Nav1.7. [PDF]
Zool Res, 2022 Yuan FC +6 more
europepmc +2 more sources
PhTx3-4, a Spider Toxin Calcium Channel Blocker, Reduces NMDA-Induced Injury of the Retina [PDF]
Toxins, 2016 The in vivo neuroprotective effect of PhTx3-4, a spider toxin N-P/Q calcium channel blocker, was studied in a rat model of NMDA-induced injury of the retina. NMDA (N-Methyl-d-Aspartate)-induced retinal injury in rats reduced the b-wave amplitude by 62% ±
Nancy Scardua Binda +11 more
doaj +2 more sources
Detection and identification of huwentoxin-IV interacting proteins by biotin-avidin chemistry combined with mass spectrometry [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2014 Background : Numerous spider toxins are of interest as tools for neurophysiological research or as lead molecules for the development of pharmaceuticals and insecticides.
Hai Yu +4 more
doaj +3 more sources
Fast desensitization of acetylcholine receptors induced by a spider toxin. [PDF]
Channels (Austin), 2021 Nicotinic acetylcholine receptors (nAChRs) are members of the "cys-loop" ligand-gated ion channel superfamily that play important roles in both the peripheral and central system. At the neuromuscular junction, the endplate current is induced by ACh binding and nAChR activation, and then, the current declines to a small steady state, even though ACh is ...
Pan NC, Zhang T, Hu S, Liu C, Wang Y.
europepmc +5 more sources
The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells. [PDF]
Toxins (Basel), 2017 Wilson D +10 more
europepmc +3 more sources