Results 221 to 230 of about 356,161 (284)

Pharmacologically active spider peptide toxins

Cellular and Molecular Life Sciences (CMLS), 2003
Advances in mass spectrometry and peptide biochemistry coupled to modern methods in electrophysiology have permitted the isolation and identification of numerous novel peptide toxins from animal venoms in recent years. These advances have also opened up the field of spider venom research, previously unexplored due to methodological limitations.
G, Corzo, P, Escoubas
openaire   +2 more sources

Spider toxin and the glutamate receptors

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1991
A neurotoxin (JSTX) was isolated from the venom of spider (Nephila clavata). JSTX blocked both the excitatory postsynaptic (EPSPs) and glutamate-induced potentials in lobster neuromuscular synapse and squid giant synapse. In mammalian central nervous system, JSTX blocked the EPSPs in CA1 pyramidal neurons resulting from stimulation of Schaffer ...
N, Kawai, A, Miwa, K, Shimazaki, Y, Sahara, H P, Robinson, T, Nakajima   +5 more
openaire   +2 more sources

Spider Polyamine Toxin

Toxin Reviews, 2005
In the early 1980s, a new type of polyamine toxins was found in the venom of several orb-web spiders. Joro spider toxins (JSTXs) in the venom of Nephila clavata and Nephila spider toxins (NSTXs) derived from Nephila maculata blocked postsynaptic glutamate receptors in the invertebrate and vertebrate nervous system.
openaire   +1 more source

Brown spider dermonecrotic toxin directly induces nephrotoxicity

Toxicology and Applied Pharmacology, 2006
Brown spider (Loxosceles genus) venom can induce dermonecrotic lesions at the bite site and systemic manifestations including fever, vomiting, convulsions, disseminated intravascular coagulation, hemolytic anemia and acute renal failure. The venom is composed of a mixture of proteins with several molecules biochemically and biologically well ...
Chaim, O. M., Sade, Y. B., Silveira, R. B. da, Toma, L., Kalapothakis, E., Chavez-Olortegui, C., Mangili, O. C., Gremski, W., von Dietrich, C. P., Nader, H. B., Veiga, S. S.   +10 more
openaire   +3 more sources

An insecticidal toxin from Nephila clavata spider venom

Amino Acids, 2017
Spiders are the most successful insect predators given that they use their venom containing insecticidal peptides as biochemical weapons for preying. Due to the high specificity and potency of peptidic toxins, discoveries of insecticidal toxins from spider venom have provided an opportunity to obtain natural compounds for agricultural applications ...
Lin Jin, Mingqian Fang, Mengrou Chen, Chunling Zhou, Rose Ombati, Md Abdul Hakim, Guoxiang Mo, R. Lai, Xiuwen Yan, Yumin Wang, Shilong Yang   +10 more
semanticscholar   +3 more sources

The Chemistry of Spider Toxins and Spider Silk

Angewandte Chemie International Edition in English, 1997
AbstractSpiders have a bad reputation because of their predacious and hidden way of life. Nevertheless, they developed a finely tuned system, based on the use of venom and silk, which enabled them to compete successfully in evolution. Only recently has the mystery of the chemistry of their silk and venom begun to unravel, although the first ...
openaire   +1 more source

Spider toxins selectively block calcium currents in drosophila

Neuron, 1989
Toxins from spider venom, originally purified for their ability to block synaptic transmission in Drosophila, are potent and specific blockers of Ca2+ currents measured in cultured embryonic Drosophila neurons using the whole-cell, patch-clamp technique.
H T, Leung, W D, Branton, H S, Phillips, L, Jan, L, Byerly   +4 more
openaire   +2 more sources

Spider peptide toxins as leads for drug development

Expert Opinion on Drug Discovery, 2007
Venomous animals use a highly complex cocktails of proteins, peptides and small molecules to subdue and kill their prey. As such, venoms represent highly valuable combinatorial peptide libraries, displaying an extensive range of pharmacological activities, honed by natural selection.
Escoubas, Pierre, Bosmans, Frank
openaire   +3 more sources

Efficient synthesis and anticancer evaluation of spider toxin peptide LVTX-8-based analogues with enhanced stability.

Bioorganic chemistry (Print), 2023
Qiao-na Chi, S. Jia, Hao Yin, Li-E Wang, Xingchuang Fu, Yan-nan Ma, Mingming Sun, Yun-Kun Qi, Zhibo Li, Shan-Shan Du   +9 more
semanticscholar   +1 more source

Peptide NCTX15 derived from spider toxin gland effectively relieves hyperuricemia in mice.

Biochemical and Biophysical Research Communications - BBRC, 2023
Yixiang Liu, Naixin Liu, Wenxin Bian, Yue Zhang, Yutong Wu, Ying Peng, Ze Ru, Zhe Fu, Yinglei Wang, Chao Li, Xinwang Yang, Ying Wang   +11 more
semanticscholar   +1 more source