Results 231 to 240 of about 356,161 (284)
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Orally active acaricidal peptide toxins from spider venom
Toxicon, 2006Numerous species of ticks and mites (collectively known as acarines) are serious pests of animals, humans, and crops. There are few commercially available acaricides and major classes of these chemicals continue to be lost from the marketplace due to resistance development or deregistration by regulatory agencies.
Mukherjee, A. K. +3 more
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Spider Venom Toxin Protects Plants from Insect Attack
Transgenic Research, 2006Many of the toxin proteins, that have been heterogeneously expressed in agricultural crops to provide resistance to insect pests, are too specific or are only mildly effective against the major insect pests. Spider venoms are a complex cocktail of toxins that have evolved specifically to kill insects.
Sher Afzal, Khan +4 more
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Neuroactive Toxins of Spider Venoms
Journal of Toxicology: Toxin Reviews, 1991AbstractA variety of neuroactive toxins have been found in the venom of spiders. The venom of Latrodectus mactans(black widow spider) is known as a potent neurotoxin, fatal to humans and animals. The effective component, α-latrotoxin (Mr=130,000) acts on the nerve terminals, causing massive release of transmitters and depletion of the synaptic vesicles,
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Characterization of Glutamate Receptor by Spider Toxin
Journal of Toxicology: Toxin Reviews, 1990AbstractRecent study has shown that the venom of some orb-web spiders contain potent blockers of the glutamate receptors. Joro spider toxin (JSTX) derived from Nephila clavata has been found to block excitatory postsynaptic potentials and glutamate-evoked responses in the neuromuscular synapse of crustacea, the squid giant synapse and the mammalian ...
Nobufumi Kawai, Terumi Nakajima
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Spider toxin and pertussis toxin differentiate post- and presynaptic glutamate receptors
Neuroscience Research, 1991A specific blocker of the postsynaptic glutamate receptors was found in the venom of the spider Nephila clavata. The toxin (JSTX) preferentially blocks quisqualate-type glutamate receptors in the crustacean neuromuscular synapse, squid giant synapse and hippocampal neurons in slice preparations. Following determination of the structure of JSTXs, a main
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ChemInform Abstract: The Chemistry of Spider Toxins and Spider Silk
ChemInform, 1997AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Polyamine Toxins from Spiders and Wasps
2014Polyamine toxins, isolated from spider and wasp venoms, are a group of small molecular weight natural products with intriguing biological activities. They are secondary metabolites used for paralyzing prey, causing an immediate, but reversible, effect on the prey.
Xiaofeng Xiong, Kristian Strømgaard
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Synthetic Analogues of Naturally Occurring Spider Toxins
Helvetica Chimica Acta, 1992AbstractNaturally occurring spider toxins are potent inhibitors of glutamate receptors of the central nervous system and have the general structure (hetero)arylacyl→aminoacyl(I)→polyamine→aminoacyl(II) (the arrow indicates the direction of an amide linkage).
Lajos Kovács, Manfred Hesse
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An efficient and versatile synthesis of acylpolyamine spider toxins
Bioorganic & Medicinal Chemistry Letters, 2002An efficient and versatile synthesis of acylpolyamine spider toxins was developed based on the structural classification of the Nephila and Nephilengys spider toxins using the 2-nitrobenzenesulfonamide protecting group. The naturally occurring toxins 1-5 representing each structural type have been efficiently synthesized by this method in a high ...
Nihei, K. +4 more
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Spider toxins targeting ligand-gated ion channels
Toxin Reviews, 2019Ligand-gated ion channels (LGIC) are membranous proteins that allow ionic flow across plasma membrane upon ligand binding.
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