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Spinal antinociceptive effect of the PnTx4(5-5) peptide is possibly mediated by the NMDA autoreceptors. [PDF]
J Venom Anim Toxins Incl Trop Disde Abreu MM +9 more
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Spider Venoms and Spider Toxins
Journal of Toxicology: Toxin Reviews, 1998AbstractSpider venoms and toxins are useful tools for the study of ion channels and synaptic functions of neurons in vertebrates and invertebrates. The components of spider venom, such as proteins, peptides, polyamines and bioamines, are species-specific. The various functions of these toxins are reviewed in this paper.
Masahisa Ori, Hiroyoshi Ikeda
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Spider toxin and the glutamate receptors
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1991A neurotoxin (JSTX) was isolated from the venom of spider (Nephila clavata). JSTX blocked both the excitatory postsynaptic (EPSPs) and glutamate-induced potentials in lobster neuromuscular synapse and squid giant synapse. In mammalian central nervous system, JSTX blocked the EPSPs in CA1 pyramidal neurons resulting from stimulation of Schaffer ...
Toshiaki Nakajima +5 more
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Pharmacologically active spider peptide toxins
Cellular and Molecular Life Sciences (CMLS), 2003Advances in mass spectrometry and peptide biochemistry coupled to modern methods in electrophysiology have permitted the isolation and identification of numerous novel peptide toxins from animal venoms in recent years. These advances have also opened up the field of spider venom research, previously unexplored due to methodological limitations.
Pierre Escoubas, Gerardo Corzo
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Toxin Reviews, 2005
In the early 1980s, a new type of polyamine toxins was found in the venom of several orb-web spiders. Joro spider toxins (JSTXs) in the venom of Nephila clavata and Nephila spider toxins (NSTXs) derived from Nephila maculata blocked postsynaptic glutamate receptors in the invertebrate and vertebrate nervous system.
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In the early 1980s, a new type of polyamine toxins was found in the venom of several orb-web spiders. Joro spider toxins (JSTXs) in the venom of Nephila clavata and Nephila spider toxins (NSTXs) derived from Nephila maculata blocked postsynaptic glutamate receptors in the invertebrate and vertebrate nervous system.
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Spider peptide toxins as leads for drug development
Expert Opinion on Drug Discovery, 2007Venomous animals use a highly complex cocktails of proteins, peptides and small molecules to subdue and kill their prey. As such, venoms represent highly valuable combinatorial peptide libraries, displaying an extensive range of pharmacological activities, honed by natural selection.
Escoubas, Pierre, Bosmans, Frank
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The Chemistry of Spider Toxins and Spider Silk
Angewandte Chemie International Edition in English, 1997AbstractSpiders have a bad reputation because of their predacious and hidden way of life. Nevertheless, they developed a finely tuned system, based on the use of venom and silk, which enabled them to compete successfully in evolution. Only recently has the mystery of the chemistry of their silk and venom begun to unravel, although the first ...
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