Results 261 to 270 of about 12,660 (287)

Characterization of Glutamate Receptor by Spider Toxin

Journal of Toxicology: Toxin Reviews, 1990
AbstractRecent study has shown that the venom of some orb-web spiders contain potent blockers of the glutamate receptors. Joro spider toxin (JSTX) derived from Nephila clavata has been found to block excitatory postsynaptic potentials and glutamate-evoked responses in the neuromuscular synapse of crustacea, the squid giant synapse and the mammalian ...
Nobufumi Kawai, Terumi Nakajima
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An efficient and versatile synthesis of acylpolyamine spider toxins

Bioorganic & Medicinal Chemistry Letters, 2002
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Nihei, K., Kato, M. J., Yamane, T., Palma, Mario Sergio, Konno, K.   +4 more
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Spider Toxins and their Potential for Insect Control

2005
Insects are the most diverse and successful animals on the planet, with the number of extant species estimated to be not, vert, similar5 million (Novotny et al., 2002). However, the ability of insects to inhabit a wide variety of ecological niches has inevitably brought them into conflict with humans.
Maggio, F., Sollod, B. L., Tedford, H. W., King, G. F.   +3 more
openaire   +3 more sources

Synthetic Analogues of Naturally Occurring Spider Toxins

Helvetica Chimica Acta, 1992
AbstractNaturally occurring spider toxins are potent inhibitors of glutamate receptors of the central nervous system and have the general structure (hetero)arylacyl→aminoacyl(I)→polyamine→aminoacyl(II) (the arrow indicates the direction of an amide linkage).
Manfred Hesse, Lajos Kovács
openaire   +3 more sources

Neuroactive Toxins of Spider Venoms

Journal of Toxicology: Toxin Reviews, 1991
AbstractA variety of neuroactive toxins have been found in the venom of spiders. The venom of Latrodectus mactans(black widow spider) is known as a potent neurotoxin, fatal to humans and animals. The effective component, α-latrotoxin (Mr=130,000) acts on the nerve terminals, causing massive release of transmitters and depletion of the synaptic vesicles,
openaire   +2 more sources

Spider toxins selectively block calcium currents in drosophila

Neuron, 1989
Toxins from spider venom, originally purified for their ability to block synaptic transmission in Drosophila, are potent and specific blockers of Ca2+ currents measured in cultured embryonic Drosophila neurons using the whole-cell, patch-clamp technique.
Lily Yeh Jan, Lou Byerly, Heidi S. Phillips, W. Dale Branton, Hung-Tat Leung   +4 more
openaire   +3 more sources

Polyamine Toxins from Spiders and Wasps

2014
Polyamine toxins, isolated from spider and wasp venoms, are a group of small molecular weight natural products with intriguing biological activities. They are secondary metabolites used for paralyzing prey, causing an immediate, but reversible, effect on the prey.
Xiao-Feng Xiong, Kristian Strømgaard
openaire   +2 more sources

Brown spider dermonecrotic toxin directly induces nephrotoxicity

Toxicology and Applied Pharmacology, 2006
Brown spider (Loxosceles genus) venom can induce dermonecrotic lesions at the bite site and systemic manifestations including fever, vomiting, convulsions, disseminated intravascular coagulation, hemolytic anemia and acute renal failure. The venom is composed of a mixture of proteins with several molecules biochemically and biologically well ...
Carl P. Dietrich, Silvio Sanches Veiga, Youssef Bacila Sade, Helena B. Nader, Rafael Bertoni da Silveira, Waldemiro Gremski, Waldemiro Gremski, Leny Toma, Oldemir C. Mangili, Evanguedes Kalapothakis, Olga Meiri Chaim, Carlos Chávez-Olórtegui   +11 more
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Black widow spider toxins: the present and the future

Toxicon, 1998
The venom of the black widow spider Latrodectus mactans tredisimguttatus was found to contain a family of high molecular weight toxic proteins inducing a sharp increase in transmitter secretion from the affected nerve endings, which are highly specific for vertebrates, or for insects, or for crustaceans.
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Spider toxin and pertussis toxin differentiate post- and presynaptic glutamate receptors

Neuroscience Research, 1991
A specific blocker of the postsynaptic glutamate receptors was found in the venom of the spider Nephila clavata. The toxin (JSTX) preferentially blocks quisqualate-type glutamate receptors in the crustacean neuromuscular synapse, squid giant synapse and hippocampal neurons in slice preparations. Following determination of the structure of JSTXs, a main
openaire   +3 more sources