Voltage-Gated Sodium Channel Modulation by a New Spider Toxin Ssp1a Isolated From an Australian Theraphosid [PDF]
Frontiers in Pharmacology, 2021 Given the important role of voltage-gated sodium (NaV) channel-modulating spider toxins in elucidating the function, pharmacology, and mechanism of action of therapeutically relevant NaV channels, we screened the venom from Australian theraphosid species
Yashad Dongol +5 more
doaj +2 more sources
Spider toxin inhibits gating pore currents underlying periodic paralysis. [PDF]
Proc Natl Acad Sci U S A, 2018 Significance Voltage-gated ion channels contain domains that have discrete functionalities. The central pore domain allows current flow and provides ion selectivity, whereas peripherally located voltage-sensing domains (VSDs) are needed for voltage ...
Männikkö R +17 more
europepmc +2 more sources
Molecular mechanism of the spider toxin κ-LhTx-I acting on the bacterial voltage-gated sodium channel NaChBac [PDF]
Frontiers in Pharmacology, 2022 The bacterial sodium channel NaChBac is the prokaryotic prototype for the eukaryotic NaV and CaV channels, which could be used as a relatively simple model to study their structure–function relationships.
Zhen Xiao +9 more
doaj +2 more sources
Gene sequence analysis of toxins from the spider Phoneutria nigriventer revealed an intronless feature [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2020 Background: Phoneutria nigriventer spider venom contains several cysteine-rich peptide toxins that act on different ion channels. Despite extensive studies on its venom and description of cDNA sequences of several of its toxin precursors, the gene ...
Ana Luiza Bittencourt Paiva +4 more
doaj +4 more sources
Phoneutria nigriventer Spider Toxin PnTx2-1 (δ-Ctenitoxin-Pn1a) Is a Modulator of Sodium Channel Gating. [PDF]
Toxins (Basel), 2018 Spider venoms are complex mixtures of biologically active components with potentially interesting applications for drug discovery or for agricultural purposes.
Peigneur S +6 more
europepmc +2 more sources
Antibacterial and Anti-Inflammatory Effects of Novel Peptide Toxin from the Spider Pardosa astrigera
Antibiotics, 2020 The prevalence of antibiotic-resistant bacteria has become an immediate threat to public health. Antimicrobial peptides are attracting attention as a new source of antibiotics due to their ability to prevent drug-resistances with fewer side effects ...
Min Kyoung Shin +8 more
doaj +2 more sources
Disease Modifying Effects of the Spider Toxin Parawixin2 in the Experimental Epilepsy Model. [PDF]
Toxins (Basel), 2017 (1) Background: Temporal lobe epilepsy (TLE) is the most common type of epilepsy in adults. It is also the one with the highest percentage of drug-resistance to the current available anti-epileptic drugs (AED).
Godoy LD +5 more
europepmc +2 more sources
Regional brain c-fos activation associated with penile erection and other symptoms induced by the spider toxin Tx2-6 [PDF]
, 2011 Brain areas expressing c-fos messenger RNA were mapped by quantitative in situ hybridization after 1-2 h of intoxication with 10 mu g/kg Tx2-6, a toxin obtained from the venom of the spider Phoneutria nigriventer.
Hipólide, Débora Cristina +6 more
core +4 more sources
Highlights in the knowledge of brown spider toxins [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2017 Brown spiders are venomous arthropods that use their venom for predation and defense. In humans, bites of these animals provoke injuries including dermonecrosis with gravitational spread of lesions, hematological abnormalities and impaired renal function.
Daniele Chaves-Moreira +5 more
doaj +4 more sources
Insect-selective spider toxins targeting voltage-gated sodium channels [PDF]
Toxicon, 2007 The voltage-gated sodium (Nav) channel is a target for a number of drugs, insecticides and neurotoxins. These bind to at least seven identified neurotoxin binding sites and either block conductance or modulate Nav channel gating.
Nicholson, GM
core +3 more sources