Exploring the SARS-CoV-2 spike protein destabilizer toxin from the scorpion, spider, and wasp group of toxins as a promising candidate for the identification of pharmacophores against viral infections. [PDF]
Open Vet JGermoush MO +7 more
europepmc +2 more sources
LCTX-F2, a Novel Potentiator of Coagulation Factors From the Spider Venom of Lycosa singoriensis
Frontiers in Pharmacology, 2020 Spider venoms contain many functional proteins/peptides such as proteinases, serine/cysteine proteinase inhibitors, insecticidal toxins, and ion channel toxins.
Pengpeng Li +6 more
doaj +1 more source
Molecules, 2021 The brown widow spider, Latrodectus geometricus, is a predator of a variety of agricultural insects and is also hazardous for humans. Its venom is a true pharmacopeia representing neurotoxic peptides targeting the ion channels and/or receptors of both ...
Pornsawan Khamtorn +5 more
doaj +1 more source
Gene sequence analysis of toxins from the spider Phoneutria nigriventer revealed an intronless feature [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2020 Background: Phoneutria nigriventer spider venom contains several cysteine-rich peptide toxins that act on different ion channels. Despite extensive studies on its venom and description of cDNA sequences of several of its toxin precursors, the gene ...
Ana Luiza Bittencourt Paiva +4 more
doaj +2 more sources
The venom gland transcriptome of Latrodectus tredecimguttatus revealed by deep sequencing and cDNA library analysis. [PDF]
PLoS ONE, 2013 Latrodectus tredecimguttatus, commonly known as black widow spider, is well known for its dangerous bite. Although its venom has been characterized extensively, some fundamental questions about its molecular composition remain unanswered.
Quanze He +5 more
doaj +1 more source
Native pyroglutamation of huwentoxin-IV: a post-translational modification that increases the trapping ability to the sodium channel. [PDF]
PLoS ONE, 2013 Huwentoxin-IV (HWTX-IV), a tetrodotoxin-sensitive (TTX-s) sodium channel antagonist, is found in the venom of the Chinese spider Ornithoctonus huwena.
Mingqiang Rong +5 more
doaj +1 more source
Dramatic expansion of the black widow toxin arsenal uncovered by multi-tissue transcriptomics and venom proteomics. [PDF]
, 2014 BackgroundAnimal venoms attract enormous interest given their potential for pharmacological discovery and understanding the evolution of natural chemistries.
Ayoub, Nadia A +4 more
core +2 more sources
VenoMS—A Website for the Low Molecular Mass Compounds in Spider Venoms
Metabolites, 2020 Spider venoms are highly complex mixtures. Numerous spider venom metabolites are uniquely found in spider venoms and are of interest concerning their potential use in pharmacology, agriculture, and cosmetics.
Yvonne M. Forster +4 more
doaj +1 more source
Venom-gland transcriptomics and venom proteomics of the Tibellus oblongus spider
Scientific Data, 2023 The Tibellus oblongus spider is an active hunter that does not spin webs and remains highly underinvestigated in terms of the venom composition. Here, we describe venom glands transcriptome and venom proteome analysis for unveiling the polypeptide ...
Yuliya Korolkova +7 more
doaj +1 more source
Scientific Reports, 2022 Prey-specialised spiders are adapted to capture specific prey items, including dangerous prey. The venoms of specialists are often prey-specific and less complex than those of generalists, but their venom composition has not been studied in detail. Here,
Ondřej Michálek +5 more
doaj +1 more source