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Neurotoxins from Spider Venoms [PDF]

, 2002
In his excellent book “Arachnida,” rich in learned citations, T. Savory (1) writes: “The spider is the dominant arachnid; it surpasses all others in the number and variety of its species, in the complexity of its habits, and in the breadth of its range across the world.
Stefano Rufini, Alfonso Grasso
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Spider Venomics: Implications for Drug Discovery

Future Medicinal Chemistry, 2014
Over a period of more than 300 million years, spiders have evolved complex venoms containing an extraordinary array of toxins for prey capture and defense against predators. The major components of most spider venoms are small disulfide-bridged peptides that are highly stable and resistant to proteolytic degradation.
Pineda, Sandy S., Undheim, Eivind A. B., Rupasinghe, Darshani B., Ikonomopoulou, Maria P., King, Glenn F.   +4 more
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Spider Venoms and Their Effect [PDF]

, 1987
In principle, with the exception of some groups of spiders which have no venom glands at all (e.g. Uloboridae and Holarchaea) all spiders with any kind of venom apparatus must be considered as venomous, if not always for man, then perhaps for other animals, or at least for insects, their usual prey.
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Structure and pharmacology of spider venom neurotoxins

Biochimie, 2000
Spider venoms are complex mixtures of neurotoxic peptides, proteins and low molecular mass organic molecules. Their neurotoxic activity is due to the interaction of the venom components with cellular receptors, in particular ion channels. Spider venoms have proven to be a rich source of highly specific peptide ligands for selected subtypes of potassium,
Pierre Escoubas, Pierre Escoubas, Sylvie Diochot, Gerardo Corzo   +3 more
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Venomous Snake and Spider Bites in Pregnancy

Obstetrical & Gynecological Survey, 2021
Importance Venomous snake and spider bites are relatively rare in the Unites States and even more so in the pregnant population. However, the impact of a venomous bite, also known as an envenomation, can be serious in a pregnant patient.
Emily, Chen, Sarah, Dotters-Katz, Jeffrey A, Kuller, Megan, Varvoutis   +3 more
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The Venom of Australian Spiders

2015
Australia is home to an estimated 10,000 species of spider, including species from the Latrodectus genera and Atracinae family, two of the four widely recognized medically significant spider groups. It is predicted in excess of 5,000 spider bite cases occurring annually in Australia, predominantly by spiders that have not shown any medical relevance ...
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Assay of Spider Venom and Antivenene in Drosophila

Nature, 1956
DURING studies on the toxicity of the venom of the Australian red back spider (L. hasseltii) it was found that the venom injected into Drosophila causes paralysis of the insect. This effect has been utilized for assaying antivenene.
Saul Wiener, Drummond Fh
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Improving therapeutic potential of antibacterial spider venom peptides: coarse-grain molecular dynamics guided approach.

Future Medicinal Chemistry, 2018
AIM Spider venom is a rich source of antibacterial peptides, whose hemolytic activity is often excessive. METHODOLOGY How to get rid of it? Using latarcins from Lachesana tarabaevi and oxyopinin Oxt 4a from Oxyopes takobius spider venoms we performed ...
P. Dubovskii, A. Ignatova, P. Volynsky, I. Ivanov, M. Zhmak, A. Feofanov, R. Efremov   +6 more
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Neurotoxins and Necrotoxins of Spider Venoms

Journal of Toxicology: Toxin Reviews, 1986
Abstractalpha-Latrotoxin, the systemic neurotoxin isolated from the venom of the Mediterranean black widow spider (Latrodectus mactans tredecimeuttatus) remains the most studied of spider venom toxins. Although some variation is reported in the chemical properties of this protein neurotoxin, all workers agree that it causes a variety of nenous tissue ...
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Venomous snake bites, scorpions, and spiders

2014
Neurologic dysfunction due to natural neurotoxins is an important, but neglected, public health hazard in many parts of the world, particularly in the tropics. These toxins are produced by or found among a variety of live forms that include venomous snakes, arthropods such as scorpions, spiders, centipedes, stinging insects (Hymenoptera), ticks ...
Nimal Senanayake, Senanayake A. M. Kularatne   +1 more
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