Results 171 to 180 of about 75,109 (200)

Spider Venomics: Implications for Drug Discovery

Future Medicinal Chemistry, 2014
Over a period of more than 300 million years, spiders have evolved complex venoms containing an extraordinary array of toxins for prey capture and defense against predators. The major components of most spider venoms are small disulfide-bridged peptides that are highly stable and resistant to proteolytic degradation.
Pineda, Sandy S., Undheim, Eivind A. B., Rupasinghe, Darshani B., Ikonomopoulou, Maria P., King, Glenn F.   +4 more
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Total Synthesis of the Spider-Venom Peptide Hi1a

Organic Letters, 2021
Hi1a is a venom peptide from the Australian funnel-web spider Hadronyche infensa with a complex tertiary structure. Hi1a has neuroprotective and cardioprotective properties due to its potent inhibition of acid-sensing ion channel 1a (ASIC1a) and is currently being pursued as a novel therapy for acute ischemic events.
Nisharnthi M. Duggan, Natalie J. Saez, Daniel Clayton, Elena Budusan, Emma E. Watson, Isaac J. Tucker, Lachlan D. Rash, Glenn F. King, Richard J. Payne   +8 more
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Structure and pharmacology of spider venom neurotoxins

Biochimie, 2000
Spider venoms are complex mixtures of neurotoxic peptides, proteins and low molecular mass organic molecules. Their neurotoxic activity is due to the interaction of the venom components with cellular receptors, in particular ion channels. Spider venoms have proven to be a rich source of highly specific peptide ligands for selected subtypes of potassium,
P, Escoubas, S, Diochot, G, Corzo
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Assay of Spider Venom and Antivenene in Drosophila

Nature, 1956
DURING studies on the toxicity of the venom of the Australian red back spider (L. hasseltii) it was found that the venom injected into Drosophila causes paralysis of the insect. This effect has been utilized for assaying antivenene.
F H, DRUMMOND, S, WIENER
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Latarcins: versatile spider venom peptides

Cellular and Molecular Life Sciences, 2015
Arthropod venoms feature the presence of cytolytic peptides believed to act synergetically with neurotoxins to paralyze prey or deter aggressors. Many of them are linear, i.e., lack disulfide bonds. When isolated from the venom, or obtained by other means, these peptides exhibit common properties.
Peter V, Dubovskii, Alexander A, Vassilevski, Sergey A, Kozlov, Alexey V, Feofanov, Eugene V, Grishin, Roman G, Efremov   +5 more
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Collagenolytic activity of snake and spider venoms

Toxicon, 1967
Abstract The venoms of the snakes B. atrox , B. Jararaca , C. durissus , A. piscivorus , and the spiders P. fera , L. erythrognatha possess proteolytic activity which attacks gelatine, casein and azocoll. Denatured (heat, urea) collagen is digested too. However, native collagen is not attacked by the enzymes present in the venoms investigated.
E, Kaiser, W, Raab
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[Venomous spiders and their venoms].

Tierarztliche Praxis, 1985
The history of araneidism is long and confusing. The superstition seems to be inexterminatable that tropical mygalomorphs and mediterranean tarantulas are dangerous for humans. It can be looked up even in the most recent edition of the widespread clinical dictionary of Pschyrembel.
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Venomous snake bites, scorpions, and spiders

2014
Neurologic dysfunction due to natural neurotoxins is an important, but neglected, public health hazard in many parts of the world, particularly in the tropics. These toxins are produced by or found among a variety of live forms that include venomous snakes, arthropods such as scorpions, spiders, centipedes, stinging insects (Hymenoptera), ticks ...
S A M, Kularatne, Nimal, Senanayake
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Proteome and peptidome profiling of spider venoms

Expert Review of Proteomics, 2008
Spider venoms are an important source of novel molecules with different pharmacological properties. Recent technological developments of proteomics, especially mass spectrometry, have greatly promoted the systematic analysis of spider venom. The enormous diversity of venom components between spider species and the lack of complete genome sequence, and ...
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Toxic and Allergic Reaction to Spider Venom

Journal of Asthma Research, 1976
(1976). Toxic and Allergic Reaction to Spider Venom. Journal of Asthma Research: Vol. 13, No. 4, pp. 185-185.
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