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Total Synthesis of the Spider-Venom Peptide Hi1a

Organic Letters, 2021
Hi1a is a venom peptide from the Australian funnel-web spider Hadronyche infensa with a complex tertiary structure. Hi1a has neuroprotective and cardioprotective properties due to its potent inhibition of acid-sensing ion channel 1a (ASIC1a) and is currently being pursued as a novel therapy for acute ischemic events.
Nisharnthi M. Duggan   +8 more
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Structure and pharmacology of spider venom neurotoxins

Biochimie, 2000
Spider venoms are complex mixtures of neurotoxic peptides, proteins and low molecular mass organic molecules. Their neurotoxic activity is due to the interaction of the venom components with cellular receptors, in particular ion channels. Spider venoms have proven to be a rich source of highly specific peptide ligands for selected subtypes of potassium,
P, Escoubas, S, Diochot, G, Corzo
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Assay of Spider Venom and Antivenene in Drosophila

Nature, 1956
DURING studies on the toxicity of the venom of the Australian red back spider (L. hasseltii) it was found that the venom injected into Drosophila causes paralysis of the insect. This effect has been utilized for assaying antivenene.
F H, DRUMMOND, S, WIENER
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Latarcins: versatile spider venom peptides

Cellular and Molecular Life Sciences, 2015
Arthropod venoms feature the presence of cytolytic peptides believed to act synergetically with neurotoxins to paralyze prey or deter aggressors. Many of them are linear, i.e., lack disulfide bonds. When isolated from the venom, or obtained by other means, these peptides exhibit common properties.
Peter V, Dubovskii   +5 more
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Collagenolytic activity of snake and spider venoms

Toxicon, 1967
Abstract The venoms of the snakes B. atrox , B. Jararaca , C. durissus , A. piscivorus , and the spiders P. fera , L. erythrognatha possess proteolytic activity which attacks gelatine, casein and azocoll. Denatured (heat, urea) collagen is digested too. However, native collagen is not attacked by the enzymes present in the venoms investigated.
E, Kaiser, W, Raab
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Venomous snake bites, scorpions, and spiders

2014
Neurologic dysfunction due to natural neurotoxins is an important, but neglected, public health hazard in many parts of the world, particularly in the tropics. These toxins are produced by or found among a variety of live forms that include venomous snakes, arthropods such as scorpions, spiders, centipedes, stinging insects (Hymenoptera), ticks ...
S A M, Kularatne, Nimal, Senanayake
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[Venomous spiders and their venoms].

Tierarztliche Praxis, 1985
The history of araneidism is long and confusing. The superstition seems to be inexterminatable that tropical mygalomorphs and mediterranean tarantulas are dangerous for humans. It can be looked up even in the most recent edition of the widespread clinical dictionary of Pschyrembel.
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The Venom of Australian Spiders

2015
Australia is home to an estimated 10,000 species of spider, including species from the Latrodectus genera and Atracinae family, two of the four widely recognized medically significant spider groups. It is predicted in excess of 5,000 spider bite cases occurring annually in Australia, predominantly by spiders that have not shown any medical relevance ...
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Toxic and Allergic Reaction to Spider Venom

Journal of Asthma Research, 1976
(1976). Toxic and Allergic Reaction to Spider Venom. Journal of Asthma Research: Vol. 13, No. 4, pp. 185-185.
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Spider Venoms and Their Effect

1987
In principle, with the exception of some groups of spiders which have no venom glands at all (e.g. Uloboridae and Holarchaea) all spiders with any kind of venom apparatus must be considered as venomous, if not always for man, then perhaps for other animals, or at least for insects, their usual prey.
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