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The molecular basis of KCNH1-related epileptic encephalopathy and the challenge of developing targeted therapeutics. [PDF]

Brain
Sundman AK, Jin S, Vadlamudi L, King GF.
europepmc   +1 more source

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Proteome and peptidome profiling of spider venoms

Expert Review of Proteomics, 2008
Spider venoms are an important source of novel molecules with different pharmacological properties. Recent technological developments of proteomics, especially mass spectrometry, have greatly promoted the systematic analysis of spider venom. The enormous diversity of venom components between spider species and the lack of complete genome sequence, and ...
Songping Liang
exaly   +3 more sources

Polypeptide neurotoxins from spider venoms

FEBS Journal, 1999
Spider venoms contain a variety of toxic components. The polypeptide toxins are divided into low and high molecular mass types. Small polypeptide toxins interacting with cation channels display spatial structure homology. They can affect the functioning of calcium, sodium, or potassium channels.
Eugene Grishin
exaly   +3 more sources

Neurotoxic acylpolyamines from spider venoms

Journal of Chemical Ecology, 1993
Meinwald Jerrold
exaly   +3 more sources

Spider Venoms and Spider Toxins

Journal of Toxicology: Toxin Reviews, 1998
AbstractSpider venoms and toxins are useful tools for the study of ion channels and synaptic functions of neurons in vertebrates and invertebrates. The components of spider venom, such as proteins, peptides, polyamines and bioamines, are species-specific. The various functions of these toxins are reviewed in this paper.
Masahisa Ori, Hiroyoshi Ikeda
openaire   +1 more source

Molecular diversity of spider venom

Biochemistry (Moscow), 2009
Spider venom, a factor that has played a decisive role in the evolution of one of the most successful groups of living organisms, is reviewed. Unique molecular diversity of venom components including substances of variable structure (from simple low molecular weight compounds to large multidomain proteins) with different functions is considered ...
A A, Vassilevski, S A, Kozlov, E V, Grishin   +2 more
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Funnelweb–Spider Venom Antagonist

Medical Journal of Australia, 1980
It was found in a series of experiments on anaesthetized monkeys that rat plasma and rat euglobulin fractions contain a substance which could offer some protection against funnelweb-spider envenomation when administered before envenomation or simultaneously with the funnelweb-spider venom. Further work to isolate, identify, and purify this substance is
R K, Atkinson, G, Brewer, W E, Glover, D, Morgans, T A, Torda   +4 more
openaire   +2 more sources

Venomous Snake and Spider Bites in Pregnancy

Obstetrical & Gynecological Survey, 2021
Importance Venomous snake and spider bites are relatively rare in the Unites States and even more so in the pregnant population. However, the impact of a venomous bite, also known as an envenomation, can be serious in a pregnant patient.
Emily, Chen, Sarah, Dotters-Katz, Jeffrey A, Kuller, Megan, Varvoutis   +3 more
openaire   +2 more sources

Spider Venomics: Implications for Drug Discovery

Future Medicinal Chemistry, 2014
Over a period of more than 300 million years, spiders have evolved complex venoms containing an extraordinary array of toxins for prey capture and defense against predators. The major components of most spider venoms are small disulfide-bridged peptides that are highly stable and resistant to proteolytic degradation.
Pineda, Sandy S., Undheim, Eivind A. B., Rupasinghe, Darshani B., Ikonomopoulou, Maria P., King, Glenn F.   +4 more
openaire   +5 more sources