A Proteomics and Transcriptomics Investigation of the Venom from the Barychelid Spider Trittame loki (Brush-Foot Trapdoor) [PDF]
Toxins, 2013 Although known for their potent venom and ability to prey upon both invertebrate and vertebrate species, the Barychelidae spider family has been entirely neglected by toxinologists. In striking contrast, the sister family Theraphosidae (commonly known as
Eivind A. B. Undheim +12 more
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Sphingomyelinase D from Loxosceles laeta Venom Induces the Expression of MMP7 in Human Keratinocytes: Contribution to Dermonecrosis. [PDF]
PLoS ONE, 2016 Envenomation by Loxosceles spider is characterized by the development of dermonecrosis. In previous studies, we have demonstrated that increased expression/secretion of matrix metalloproteinases 2 and 9, induced by Loxosceles intermedia venom Class 2 ...
Mara A Corrêa +4 more
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Genomic and transcriptomic analyses support a silk gland origin of spider venom glands [PDF]
BMC Biology, 2023 Background Spiders comprise a hyperdiverse lineage of predators with venom systems, yet the origin of functionally novel spider venom glands remains unclear.
Bingyue Zhu +5 more
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Spider-Venom Peptides: Structure, Bioactivity, Strategy, and Research Applications [PDF]
Molecules, 2023 Spiders (Araneae), having thrived for over 300 million years, exhibit remarkable diversity, with 47,000 described species and an estimated 150,000 species in existence. Evolving with intricate venom, spiders are nature’s skilled predators.
Ruiyin Guo +5 more
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Enlightening the toxinological dark matter of spider venom enzymes [PDF]
npj BiodiversitySpiders produce highly adapted venoms featuring a complex mixture of biomolecules used mainly for hunting and defense. The most prominent components are peptidic neurotoxins, a major focus of research and drug development, whereas venom enzymes have been
Josephine Dresler +3 more
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Phlogiellus bundokalbo spider venom: cytotoxic fractions against human lung adenocarcinoma (A549) cells [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2020 Background: Spider venom is a potential source of pharmacologically important compounds. Previous studies on spider venoms reported the presence of bioactive molecules that possess cell-modulating activities.
Anna Beatriz R. Mayor +3 more
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Prospects and challenges of recombinant spider venom enzymes: insights from Loxosceles and Phoneutria venom protease expressions [PDF]
Frontiers in Bioengineering and BiotechnologySpiders use chemically complex venoms to overpower prey. Such venoms are primarily composed of neurotoxic disulfide-rich peptides, linear peptides, and enzymes.
Josephine Dresler +11 more
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Can we resolve the taxonomic bias in spider venom research? [PDF]
Toxicon: X, 2019 The rate of discovery of new spider species greatly exceeds the rate of spider venom characterisation, leading to an increasing number of species with unstudied venoms.
Volker Herzig +2 more
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Complex precursor structures of cytolytic cupiennins identified in spider venom gland transcriptomes [PDF]
Scientific Reports, 2021 Analysis of spider venom gland transcriptomes focuses on the identification of possible neurotoxins, proteins and enzymes. Here, the first comprehensive transcriptome analysis of cupiennins, small linear cationic peptides, also known as cytolytic or ...
Lucia Kuhn-Nentwig
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Toxinology in the proteomics era: a review on arachnid venom proteomics [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2022 The word venomics was coined to acknowledge the studies that use omics to investigate venom proteins and peptides. Venomics has evolved considerably over the last 20 years. The first works on scorpion or spider venomics were published in the early 2000’s.
Filipi Calbaizer Marchi +4 more
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