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Polypeptide neurotoxins from spider venoms

European Journal of Biochemistry, 1999
Spider venoms contain a variety of toxic components. The polypeptide toxins are divided into low and high molecular mass types. Small polypeptide toxins interacting with cation channels display spatial structure homology. They can affect the functioning of calcium, sodium, or potassium channels.
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Venomous snake bites, scorpions, and spiders

2014
Neurologic dysfunction due to natural neurotoxins is an important, but neglected, public health hazard in many parts of the world, particularly in the tropics. These toxins are produced by or found among a variety of live forms that include venomous snakes, arthropods such as scorpions, spiders, centipedes, stinging insects (Hymenoptera), ticks ...
S A M, Kularatne, Nimal, Senanayake
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Neurotoxins from Spider Venoms

2002
In his excellent book “Arachnida,” rich in learned citations, T. Savory (1) writes: “The spider is the dominant arachnid; it surpasses all others in the number and variety of its species, in the complexity of its habits, and in the breadth of its range across the world.
Alfonso Grasso, Stefano Rufini
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[Venomous spiders and their venoms].

Tierarztliche Praxis, 1985
The history of araneidism is long and confusing. The superstition seems to be inexterminatable that tropical mygalomorphs and mediterranean tarantulas are dangerous for humans. It can be looked up even in the most recent edition of the widespread clinical dictionary of Pschyrembel.
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Structure and pharmacology of spider venom neurotoxins

Biochimie, 2000
Spider venoms are complex mixtures of neurotoxic peptides, proteins and low molecular mass organic molecules. Their neurotoxic activity is due to the interaction of the venom components with cellular receptors, in particular ion channels. Spider venoms have proven to be a rich source of highly specific peptide ligands for selected subtypes of potassium,
P, Escoubas, S, Diochot, G, Corzo
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Neuroactive Toxins of Spider Venoms

Journal of Toxicology: Toxin Reviews, 1991
AbstractA variety of neuroactive toxins have been found in the venom of spiders. The venom of Latrodectus mactans(black widow spider) is known as a potent neurotoxin, fatal to humans and animals. The effective component, α-latrotoxin (Mr=130,000) acts on the nerve terminals, causing massive release of transmitters and depletion of the synaptic vesicles,
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The Acylpolyamines from Spider Venoms

2012
Abstract Acylpolyamines are low molecular mass toxins occurring exclusively in the venoms from solitary wasps and some groups of spiders. Their chemical structures have been elucidated using hyphenated techniques of mass spectrometry, such as LC–MS and MS/MS, or through direct analysis with different types of NMR analyses.
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