Results 71 to 80 of about 4,510 (237)

Painful toxins acting at TRPV1 [PDF]

open access: yes, 2008
Many plant and animal toxins cause aversive behaviors in animals due to their pungent or unpleasant taste or because they cause other unpleasant senstations like pain.
Cromer, B, McIntyre, P
core   +1 more source

Volumetric Comparison of Overall Brain and Neuropil Size Between Social and Non‐social Spiders: Exploring the Social Brain Hypothesis

open access: yesIntegrative Zoology, EarlyView.
Brain size may be influenced by the cognitive demands of sociality (social brain hypothesis). We used microCT to compare CNS and brain volumes in social versus solitary huntsman and crab spiders. Social huntsman spiders had larger arcuate and mushroom bodies, while social crab spiders had larger visual neuropils.
Vanessa Penna‐Gonçalves   +6 more
wiley   +1 more source

Protease inhibitors from marine venomous animals and their counterparts in terrestrial venomous animals [PDF]

open access: yes, 2013
The Kunitz-type protease inhibitors are the best-characterized family of serine protease inhibitors, probably due to their abundance in several organisms.
Mourão, Caroline Barbosa Farias   +1 more
core   +3 more sources

Structure–Function and Therapeutic Potential of Spider Venom-Derived Cysteine Knot Peptides Targeting Sodium Channels

open access: yesFrontiers in Pharmacology, 2019
Spider venom-derived cysteine knot peptides are a mega-diverse class of molecules that exhibit unique pharmacological properties to modulate key membrane protein targets.
Fernanda C. Cardoso, Richard J. Lewis
doaj   +1 more source

Beyond Manoeuvre Theory for European Defence

open access: yesGlobal Policy, EarlyView.
ABSTRACT This article contributes to the debate about European defence in the light of the Russo‐Ukraine war and growing doubts about US commitment to Europe. It argues that Europeans need to fundamentally relearn the ability to imagine military strategy from a European viewpoint.
Lukas Mengelkamp, Sam Vincent
wiley   +1 more source

‘We Are Only Playing’: Reflections on the Pandemic's Effects on Immigrant Preschoolers' Mentalisation and Play During the Sand Play Workshops

open access: yesChildren &Society, EarlyView.
ABSTRACT Mentalisation and symbolisation are important processes to support children in understanding their lived experience. By expressing what is most salient to them through pretend play, children can normally develop their capacity to mentalise and symbolise, which helps them cope with adversity.
Caroline Beauregard
wiley   +1 more source

CSTX-1, a toxin from the venom of the hunting spider Cupiennius salei, is a selective blocker of L-type calcium channels in mammalian neurons [PDF]

open access: yes, 2007
The inhibitor cystine-knot motif identified in the structure of CSTX-1 from Cupiennius salei venom suggests that this toxin may act as a blocker of ion channels.
Beirão, PSL   +8 more
core   +1 more source

The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells

open access: yesToxins, 2017
Spider venoms constitute incredibly diverse libraries of compounds, many of which are involved in prey capture and defence. Polyamines are often prevalent in the venom and target ionotropic glutamate receptors. Here we show that a novel spider polyamine,
David Wilson   +10 more
doaj   +1 more source

The mining of toxin-like polypeptides from EST database by single residue distribution analysis [PDF]

open access: yes, 2011
Background Novel high throughput sequencing technologies require permanent development of bioinformatics data processing methods. Among them, rapid and reliable identification of encoded proteins plays a pivotal role.
Sergey Kozlov, Eugene Grishin
core   +1 more source

Venomic and pharmacological activity of Acanthoscurria paulensis (Theraphosidae) spider venom

open access: yesToxicon, 2013
In the present study we conducted proteomic and pharmacological characterizations of the venom extracted from the Brazilian tarantula Acanthoscurria paulensis, and evaluated the cardiotoxicity of its two main fractions. The molecular masses of the venom components were identified by mass spectrometry (MALDI-TOF-MS) after chromatographic separation ...
Mourão, Caroline Barbosa F.   +11 more
openaire   +2 more sources

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