Results 91 to 100 of about 525,422 (309)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
VirusesSARS-CoV-2 infection remains a global burden. Despite intensive research, the mechanism and dynamics of early viral replication are not completely understood, such as the kinetics of the formation of genomic RNA (gRNA), sub-genomic RNA (sgRNA), and ...
Rajiv Pathak +9 more
doaj +1 more source
White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian +8 more
wiley +1 more source
History of The Royal Court of the Golden Spike Empire up to 2013
, 2013 Text document Page 23 of the 2013 Royal Court of the Golden Spike Empire Coronation Program. a brief historical overview of the Royal Court of the Golden Spike Empire, Utah Oldest LGBT Organization June 1976- Present. with photo Illustration of Pepper
The Royal Court of the Golden Spike Empire
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Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif +17 more
wiley +1 more source
2013 The Royal Court of the Golden Spike Empire Community Service Award Announcement
, 2013 Text document page 22 of the 2013 Royal Court of the Golden Spike Empire coronation program. Community Service award announcement for the 2013 year, Sheneka Christy Empress 20 & 32Converted from .png to .pdf for compatibility; pages combined into one ...
The Royal Court of the Golden Spike Empire
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Methods and ProtocolsSARS-CoV-2, the agent responsible for coronavirus disease in 2019 (COVID-19), has caused extensive global health and socioeconomic impact due to its transmissibility and pathology.
Martin A. Rossotti +5 more
doaj +1 more source
Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein
Viruses, 2012 Coronaviruses are enveloped positive-stranded RNA viruses that replicate in the cytoplasm. To deliver their nucleocapsid into the host cell, they rely on the fusion of their envelope with the host cell membrane.
Gary R. Whittaker +3 more
doaj +1 more source
Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay +15 more
wiley +1 more source
How feedback inhibition shapes spike-timing-dependent plasticity and its implications for recent Schizophrenia models [PDF]
, 2011 It has been shown that plasticity is not a fixed property but, in fact, changes depending on the location of the synapse on the neuron and/or changes of biophysical parameters.
Di Prodi, P. +18 more
core +1 more source