Results 81 to 90 of about 387,621 (269)
A High-Precision ID-TIMS U-Pb Dating Method of Apatite
Yankuang ceshiApatite belongs to the hexagonal crystal system and has a relatively high (350-550℃) closure temperature, which can accommodate multiple element substitutions into the crystal lattice.
Jiarun TU +5 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon +11 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi +5 more
wiley +1 more source
Introduction: The Economics of Lordship in Late Medieval and Early Modern Europe
Jahrbuch für WirtschaftsgeschichteThis special issue focuses on the economics of lordship in pre-industrial Europe. In the introduction, we start by briefly defining lordship, focusing on both the economic power lords had to demand rents from their tenants and the political power lords ...
Gibbs Spike, Skambraks Tanja
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian +8 more
wiley +1 more source
Journal of High Energy Physics, 2018 Abstract We introduce the spiked monopole, which is a ’t Hooft-Polyakov monopole with two charged scalar Higgs fields, of which one enjoys a quartic self-interaction. The free Higgs field behaves as in a BPS monopole, reducing the inter-monopole repulsion. The other Higgs has a spiked profile similar to a non-BPS monopole.
openaire +3 more sources
Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier +6 more
wiley +1 more source
Frontiers in Molecular Biosciences, 2020 Learning from the lengthy fight against HIV-1, influenza, and Ebola virus infection, broadly neutralizing antibodies (bnAbs), directed at conserved regions of surface proteins crucial to virus entry (Env, hemagglutinin, and GP, respectively), are an ...
Luca Vangelista, Massimiliano Secchi
doaj +1 more source