Results 61 to 70 of about 525,422 (309)

Modular Evolution of Coronavirus Genomes

Viruses, 2021
The viral family Coronaviridae comprises four genera, termed Alpha-, Beta-, Gamma-, and Deltacoronavirus. Recombination events have been described in many coronaviruses infecting humans and other animals.
Yulia Vakulenko, Andrei Deviatkin, Jan Felix Drexler, Alexander Lukashev   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Paddle-to-Podium: a four-phased applied research model, translating research into practice for female surfers

Frontiers in Sports and Active Living
The announcement of Teahupo’o, Tahiti as the location for surfing events at the Paris 2024 Olympic Games prompted a focus on performance research specific to female surfers. Following a 14-year absence of competitive female surfing at Teahupo’o, athletes
J. Parsonage, M. MacDonald, M. MacDonald, M. Shephard, S. Gosney, S. Gosney, S. Gosney, A. Denny, A. Denny, A. Denny, C. Minahan, C. Minahan   +11 more
doaj   +1 more source

Is Greenberg’s “Macro-Carib” viable? [PDF]

Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas, 2007
In his landmark work Language in the Americas, Greenberg (1987) proposed that Macro-Carib was one of the major low-level stocks of South America, which together with Macro-Panoan and Macro-Ge-Bororo were claimed to comprise the putative Ge-Pano-Carib ...
Spike Gildea, Doris Payne
doaj  

Mutations and Evolution of the SARS-CoV-2 Spike Protein

Viruses, 2022
The SARS-CoV-2 spike protein mediates target recognition, cellular entry, and ultimately the viral infection that leads to various levels of COVID-19 severities. Positive evolutionary selection of mutations within the spike protein has led to the genesis
Nicholas Magazine, Tianyi Zhang, Yingying Wu, Michael C. McGee, Gianluca Veggiani, Weishan Huang   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Whose was the Fifteenth-century Manor Court?

Jahrbuch für Wirtschaftsgeschichte
As part of a wider literature challenging the notion that many lords engaged in extensive surplus extraction, a recent study focused on inland Flanders has argued that we need to decouple seigneuries, the institutions which structured lordship on the ...
Gibbs Spike
doaj   +1 more source

Sensitive and Specific Detection of Low-Level Antibody Responses in Mild Middle East Respiratory Syndrome Coronavirus Infections

Emerging Infectious Diseases, 2019
Middle East respiratory syndrome coronavirus (MERS-CoV) infections in humans can cause asymptomatic to fatal lower respiratory lung disease. Despite posing a probable risk for virus transmission, asymptomatic to mild infections can go unnoticed; a lack ...
Nisreen M.A. Okba, V. Stalin Raj, Ivy Widjaja, Corine H. Geurts van Kessel, Erwin de Bruin, Felicity D. Chandler, Wan Beom Park, Nam-Joong Kim, Elmoubasher A.B.A. Farag, Mohammed Al-Hajri, Berend-Jan Bosch, Myoung-don Oh, Marion P.G. Koopmans, Chantal B.E.M. Reusken, Bart L. Haagmans   +14 more
doaj   +1 more source

ACE2 receptor polymorphism in humans and animals increases the risk of the emergence of SARS-CoV-2 variants during repeated intra- and inter-species host-switching of the virus

Frontiers in Microbiology, 2023
Like other coronaviruses, SARS-CoV-2 has ability to spread through human-to-human transmission and to circulate from humans to animals and from animals to humans.
Christian A. Devaux, Christian A. Devaux, Jacques Fantini   +2 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source