Results 51 to 60 of about 389,245 (269)

Stimulation of Potent Humoral and Cellular Immunity via Synthetic Dual-Antigen MVA-Based COVID-19 Vaccine COH04S1 in Cancer Patients Post Hematopoietic Cell Transplantation and Cellular Therapy

Vaccines, 2023
Hematopoietic cell transplantation (HCT) and chimeric antigen receptor (CAR)-T cell patients are immunocompromised, remain at high risk following SARS-CoV-2 infection, and are less likely than immunocompetent individuals to respond to vaccination.
Flavia Chiuppesi, Sandra Ortega-Francisco, Miguel-Angel Gutierrez, Jing Li, Minh Ly, Katelyn Faircloth, Jada Mack-Onyeike, Corinna La Rosa, Sandra Thomas, Qiao Zhou, Jennifer Drake, Cynthia Slape, Paolo Fernando, Wasima Rida, Teodora Kaltcheva, Alba Grifoni, Alessandro Sette, Angela Patterson, Shannon Dempsey, Brian Ball, Haris Ali, Amandeep Salhotra, Anthony Stein, Nitya Nathwani, Michael Rosenzweig, Liana Nikolaenko, Monzr M. Al Malki, Jana Dickter, Deepa D. Nanayakkara, Alfredo Puing, Stephen J. Forman, Randy A. Taplitz, John A. Zaia, Ryotaro Nakamura, Felix Wussow, Don J. Diamond, Sanjeet S. Dadwal   +36 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Athlete and Support Staff Perceptions of Training Modalities for the Development of Surfing-Specific Manoeuvres: A Concept Mapping Approach

Journal of Coaching and Sports Science
This study investigated the perspectives of surfers and support staff on the importance and feasibility of common surfing training modalities. The Concept Systems groupwisdomTM web platform was used to collect and analyse data from 29 participants (18 ...
Rick Dann, Jonathon Headrick, Llion Roberts, Vincent Kelly, Alex Donaldson, Alec McKenzie, Steven Duhig   +6 more
doaj   +1 more source

Is Greenberg’s “Macro-Carib” viable? [PDF]

Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas, 2007
In his landmark work Language in the Americas, Greenberg (1987) proposed that Macro-Carib was one of the major low-level stocks of South America, which together with Macro-Panoan and Macro-Ge-Bororo were claimed to comprise the putative Ge-Pano-Carib ...
Spike Gildea, Doris Payne
doaj  

Serum Level of Anti-Nucleocapsid, but Not Anti-Spike Antibody, Is Associated with Improvement of Long COVID Symptoms

Vaccines, 2022
Background: Long COVID is a condition characterized by long-term sequelae persisting after the typical convalescence period of COVID-19. Previous reports have suggested the role of an unsatisfactory immune response and impaired viral clearance in the ...
Reka Varnai, Tihamer Molnar, Laszlo Zavori, Margit Tőkés-Füzesi, Zsolt Illes, Andrea Kanizsai, Peter Csecsei   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Paddle-to-Podium: a four-phased applied research model, translating research into practice for female surfers

Frontiers in Sports and Active Living
The announcement of Teahupo’o, Tahiti as the location for surfing events at the Paris 2024 Olympic Games prompted a focus on performance research specific to female surfers. Following a 14-year absence of competitive female surfing at Teahupo’o, athletes
J. Parsonage, M. MacDonald, M. MacDonald, M. Shephard, S. Gosney, S. Gosney, S. Gosney, A. Denny, A. Denny, A. Denny, C. Minahan, C. Minahan   +11 more
doaj   +1 more source

Rapid Detection of Wheat Ears in Orthophotos From Unmanned Aerial Vehicles in Fields Based on YOLOX

Frontiers in Plant Science, 2022
Wheat ears in unmanned aerial vehicles (UAV) orthophotos are characterized by occlusion, small targets, dense distribution, and complex backgrounds. Rapid identification of wheat ears in UAV orthophotos in a field environment is critical for wheat yield ...
Yao Zhaosheng, Yao Zhaosheng, Liu Tao, Liu Tao, Yang Tianle, Yang Tianle, Ju Chengxin, Ju Chengxin, Sun Chengming, Sun Chengming   +9 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Exosome-Based Multivalent Vaccine: Achieving Potent Immunization, Broadened Reactivity, and Strong T-Cell Responses with Nanograms of Proteins

Microbiology Spectrum, 2023
Currently approved vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have focused solely on the spike protein to provide immunity. The first vaccines were developed rapidly using spike mRNA delivered by lipid nanoparticles but
Mafalda Cacciottolo, Justin B Nice, Yujia Li, Michael J. LeClaire, Ryan Twaddle, Ciana L. Mora, Stephanie Y. Adachi, Esther R. Chin, Meredith Young, Jenna Angeles, Kristi Elliott, Minghao Sun   +11 more
doaj   +1 more source