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Current and Future Direct-Acting Antivirals Against COVID-19

Frontiers in Microbiology, 2020
The coronavirus disease of 2019 (COVID-19) has caused an unprecedented global crisis. The etiological agent is a new virus called the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). As of October, 2020 there have been 45.4 million confirmed
Shiu-Wan Chan
doaj   +1 more source

Introduction of Two Prolines and Removal of the Polybasic Cleavage Site Lead to Higher Efficacy of a Recombinant Spike-Based SARS-CoV-2 Vaccine in the Mouse Model

mBio, 2021
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as the prime target for vaccine development. The spike protein mediates both binding to host cells and membrane fusion and is also so far the only known
Fatima Amanat, Shirin Strohmeier, Raveen Rathnasinghe, Michael Schotsaert, Lynda Coughlan, Adolfo García-Sastre, Florian Krammer   +6 more
doaj   +1 more source

Rethinking, Returning, Reflecting [PDF]

Alternatif Politika, 2017
After almost four decades of feminist International Relations (IR), I here rethink the journey this has entailed – for myself and others -- and contemplate where it has taken us.
V. Spike Peterson
doaj  

Comparative Analysis and Classification of SARS-CoV-2 Spike Protein Structures in PDB

COVID, 2023
The Spike (S) protein of the SARS-CoV-2 virus that causes the COVID-19 disease is considered the most important target for vaccine, drug and therapeutic research as it attaches and binds to the ACE2 receptor of the host cells and allows the entry of this
Memoona Aslam, M. Saqib Nawaz, Philippe Fournier-Viger, Wenjin Li   +3 more
doaj   +1 more source

Heuristic Spike Sorting Tuner (HSST), a framework to determine optimal parameter selection for a generic spike sorting algorithm [PDF]

, 2020
Extracellular microelectrodes frequently record neural activity from more than one neuron in the vicinity of the electrode. The process of labeling each recorded spike waveform with the identity of its source neuron is called spike sorting and is often ...
Bjånes, David A., Fisher, Lee E., Gaunt, Robert A., Weber, Douglas J.   +3 more
core  

Spike statistics

, 2012
In this paper we explore stochastical and statistical properties of so-called recurring spike induced Kasner sequences. Such sequences arise in recurring spike formation, which is needed together with the more familiar BKL scenario to yield a complete ...
Heinzle, J. Mark, Uggla, Claes
core   +1 more source

The impact of spike timing variability on the signal-encoding performance of neural spiking models [PDF]

, 2002
It remains unclear whether the variability of neuronal spike trains in vivo arises due to biological noise sources or represents highly precise encoding of temporally varying synaptic input signals. Determining the variability of spike timing can provide
Koch, Christof, Manwani, Amit, Steinmetz, Peter N.   +2 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Vaccines against COVID-19: Priority to mRNA-Based Formulations

Cells, 2021
As of September 2021, twenty-one anti-COVID-19 vaccines have been approved in the world. Their utilization will expedite an end to the current pandemic.
Steve Pascolo
doaj   +1 more source

Existence and Stability of a Spike in the Central Component for a Consumer Chain Model [PDF]

, 2015
We study a three-component consumer chain model which is based on Schnakenberg type kinetics. In this model there is one consumer feeding on the producer and a second consumer feeding on the first consumer.
A Doelman, A Doelman, A Doelman, AM Turing, D Iron, DL Benson, EN Dancer, H Meinhardt, H Meinhardt, J Liu, J Schnakenberg, J Wei, J Wei, J Wei, J Wei, J Wei, J Wei, J Wei, J Wei, J Wei, J Wei, J Wei, J Wei, JD Murray, Juncheng Wei, L Bettencourt, M Eigen, M Eigen, M Eigen, M Eigen, Matthias Winter, MJ Ward, P Gray, P Gray, T Kolokolnikov, T Kolokolnikov, W-M Ni, W-M Ni, W-M Ni, Y Nishiura, Y Nishiura   +40 more
core   +2 more sources