Results 41 to 50 of about 387,621 (269)

“Wit” Teaching About Death, Dying, Clinical Trials, and DNR

open access: yesMedEdPORTAL, 2009
Introduction This resource is a small-group activity aimed to facilitate discussions after a viewing of the Emmy award-winning movie “Wit.” The facilitator's guide and accompanying materials will enable faculty to lead small groups to effectively discuss
Jeffrey Spike, Christie Sain
doaj   +1 more source

Decay rate of antiS1/S2 IgG serum levels after 6 months of BNT162b2 vaccination in a cohort of COVID-19-naive and COVID-19-experienced subjects

open access: yesHuman Vaccines & Immunotherapeutics, 2022
Vaccination toward SARS-CoV-2 reduced mortality and ‘boosters’ are being implemented. We offer scientific contribution about IgG production in the COVID-19 experienced population.
Fabio Borgonovo   +14 more
doaj   +1 more source

The Screening of Broadly Neutralizing Antibodies Targeting the SARS-CoV-2 Spike Protein by mRNA Immunization in Mice

open access: yesPharmaceutics, 2023
Neutralizing antibodies (nAbs), the popular antiviral drugs used for the treatment of COVID-19, are effective in reducing viral load and hospitalization.
Zhiyin An   +8 more
doaj   +1 more source

Effect of the N501Y Mutation on Ligands Complexed with SARS-CoV-2 RBD: Insights on Potential Drug Candidates for COVID-19

open access: yesDrugs and Drug Candidates, 2023
Bioactive compounds against SARS-CoV-2 targets could be potential treatments for COVID-19. Inhibitors of the receptor-binding domain (RBD) on the viral spike protein can block its binding to the human angiotensin-converting enzyme type II (ACE2) receptor.
Camila Fonseca Amorim da Silva   +6 more
doaj   +1 more source

Spike Train Decoding Without Spike Sorting [PDF]

open access: yesNeural Computation, 2008
We propose a novel paradigm for spike train decoding, which avoids entirely spike sorting based on waveform measurements. This paradigm directly uses the spike train collected at recording electrodes from thresholding the bandpassed voltage signal.
openaire   +3 more sources

Current and Future Direct-Acting Antivirals Against COVID-19

open access: yesFrontiers in Microbiology, 2020
The coronavirus disease of 2019 (COVID-19) has caused an unprecedented global crisis. The etiological agent is a new virus called the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). As of October, 2020 there have been 45.4 million confirmed
Shiu-Wan Chan
doaj   +1 more source

Introduction of Two Prolines and Removal of the Polybasic Cleavage Site Lead to Higher Efficacy of a Recombinant Spike-Based SARS-CoV-2 Vaccine in the Mouse Model

open access: yesmBio, 2021
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as the prime target for vaccine development. The spike protein mediates both binding to host cells and membrane fusion and is also so far the only known
Fatima Amanat   +6 more
doaj   +1 more source

Rethinking, Returning, Reflecting [PDF]

open access: yesAlternatif Politika, 2017
After almost four decades of feminist International Relations (IR), I here rethink the journey this has entailed – for myself and others -- and contemplate where it has taken us.
V. Spike Peterson
doaj  

Comparative Analysis and Classification of SARS-CoV-2 Spike Protein Structures in PDB

open access: yesCOVID, 2023
The Spike (S) protein of the SARS-CoV-2 virus that causes the COVID-19 disease is considered the most important target for vaccine, drug and therapeutic research as it attaches and binds to the ACE2 receptor of the host cells and allows the entry of this
Memoona Aslam   +3 more
doaj   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro   +11 more
wiley   +1 more source

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