Results 51 to 60 of about 158,895 (307)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Epidemiology of spinal cord injuries and risk factors for complete injuries in Guangdong, China: a retrospective study. [PDF]

PLoS ONE, 2014
BACKGROUND: Spinal cord injuries are highly disabling and deadly injuries. Currently, few studies focus on non-traumatic spinal cord injuries, and there is little information regarding the risk factors for complete injuries.
Rui Yang, Lan Guo, Peng Wang, Lin Huang, Yong Tang, Wenhao Wang, Keng Chen, Jichao Ye, Ciyong Lu, Yanfeng Wu, Huiyong Shen   +10 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Role of peripheral quantitative computed tomography in identifying disuse osteoporosis in paraplegia [PDF]

, 2009
Objective: Disuse osteoporosis is a major long-term health consequence of spinal cord injury (SCI) that still needs to be addressed. Its management in SCI should begin with accurate diagnosis, followed by targeted treatments in the most vulnerable ...
A Frotzler, A Frotzler, AA Freehafer, Alan N. McLean, B Chen, David B. Allan, ED Bruin de, HH Bolotin, HM Frost, J Rittweger, JL Ferretti, L Giangregorio, L Maimoun, M Bélanger, P Eser, P Eser, P Eser, P Frey-Rindova, P Vestergaard, S Dudley-Javoroski, S-D Jiang, Sylvie Coupaud, T Mohr   +22 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source

Epidemiology of traumatic spinal cord injury: The substantial role of imaging methods [PDF]

, 2016
Background and aims: One of the most common injuries around the world is the traumatic injury of the spine and spinal cord with unknown worldwide situation of traumatic spinal cord injury (TSCI) affecting on the effectiveness of preventive policy ...
Amiri, Masoud., Fatehi, Daryoush., Masoumi, Hossein., Rostamzadeh, Ayoob.   +3 more
core   +1 more source

Therapeutic efficacy of microtube-embedded chondroitinase ABC in a canine clinical model of spinal cord injury [PDF]

, 2018
Many hundreds of thousands of people around the world are living with the long-term consequences of spinal cord injury and they need effective new therapies.
Albin, Barritt, Bartus, Biering-Sørensen, Bowes, Bradbury, Bradbury, Cafferty, Combrisson, Crespo, da Costa, Fawcett, Frank, Freedman, Gallucci, Garcia-Alias, Granger, Griffiths, Gutierrez-Quintana, Hamilton, Harris, Hilary Z Hu, Jefferson, Kwon, Kwon, Kwon, Lankhorst, Lee, Levine, Lin, Massey, Metz, Moore, Nashmi, Nick D Jeffery, Nicolas Granger, Nollet, Poncelet, Ravi V Bellamkonda, S Balakrishna Pai, Smith, Sylvestre, Tetzlaff, Toppercer, Watzlawick, Wicki, Yick   +46 more
core   +2 more sources

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Prediction of functional outcome after spinal cord injury: a task for the rehabilitation team and the patient [PDF]

, 2000
Study design: Descriptive analysis of data gathered in an information system.Objectives: To explore the predictions of professionals and patients regarding functional outcome after spinal cord injury related to the final results after inpatient ...
Eisma, W.H., Groothoff, J.W., Mulder, G.A., Schönherr, M.C.   +3 more
core   +2 more sources