Results 61 to 70 of about 84,237 (265)

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

Surgical Outcomes of Patients with Traumatic Spinal Cord Injuries in Three Referral Hospitals in Cameroon: Retrospective study

The Annals of African Surgery
Background: Traumatic spinal cord injuries (TSCIs) represent a major global health challenge affecting survival and quality of life. In resource-limited settings, their management is complicated due to restricted healthcare access and a high incidence of
Ben Ousmanou Djoubairou, Bello Figuim, Boris Gbassara Koulagna, Oumarou Haman Nassourou, Lonzi Teukeu Danielle Carole, Djientcheu Vincent de Paul   +5 more
doaj   +1 more source

Penetrating Spinal Injuries, Cases Registry in Sohag University Hospital

Egyptian Spine Journal, 2016
Background Data: Penetrating spinal cord injuries caused by missile or stab wound injuries are uncommon. The harm may be due to the direct injurious effect or may be due to the resulting vascular insult either in the form of an intra- or extradural ...
Ahmed Saro, Roshdy Elkhayat
doaj   +1 more source

Metabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease ...
Matteo Zanovello, Francesca Serani, Alen Bebeti, Federica Paredi, Giulia Quadrio, Andrea Fortuna, Giacomo Maria Minicuci, Elena Pegoraro, Annachiara Cagnin, Diego Cecchin, Gianni Sorarù   +10 more
wiley   +1 more source

Anti-Nogo-A NG101 treatment induces changes in spinal cord micro- and macrostructure following spinal cord injury

Nature Communications
NG101 is a recombinant antibody that neutralizes the nerve growth inhibitor Nogo-A, promoting neural repair and improving upper extremity motor function in spinal cord injury (SCI).
Lynn Farner, Paulina S. Scheuren, Kiomars Sharifi, Tim M. Emmenegger, Maryam Seif, Michèle Hubli, Martin Schubert, Marc Bolliger, Rüdiger Rupp, Norbert Weidner, Rainer Abel, Doris Maier, Klaus Röhl, Michael Baumberger, Margret Hund-Georgiadis, Marion Saur, Jesús Benito, Kerstin Rehahn, Mirko Aach, Andreas Badke, Jiri Kriz, Tim Killeen, Alan J. Thompson, Nikolaus Weiskopf, Martin E. Schwab, Armin Curt, Patrick Freund, the Nogo Inhibition in Spinal Cord Injury (NISCI) Study Group   +27 more
doaj   +1 more source

Association Between Neurofilament Light Chain and Real‐World Ambulatory Function in Progressive MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurofilament light chain (NfL) is a biomarker of neuroaxonal injury in multiple sclerosis (MS), yet associations with functional outcomes remain unclear. Longitudinal associations between serum NfL (sNfL) and daily step count (STEPS) from wearable devices were assessed in a large international progressive MS cohort.
Gabby B. Joseph, Megan McCune, Riley Bove, Ahmed Abdelhak, Bruce A. C. Cree, Valerie J. Block   +5 more
wiley   +1 more source

Advances in Sustainable and Wearable Textile Based Soft Robotics

Advanced Functional Materials, EarlyView.
This Review examines advances in wearable textile‐based soft robotics, focusing on sustainable materials, integrated sensing, and scalable actuation. It discusses manufacturing and system integration across healthcare, assistive robotics, prosthetics, and human–machine interfaces, and highlights key challenges in circular design, including life‐cycle ...
Zahir Abbas, Marzia Dulal, Sophia K. Novoselov, Victoria K. Novoselov, Kostya S. Novoselov, Shaila Afroj, Nazmul Karim   +6 more
wiley   +1 more source

Mechanisms of isolated spinal cord injury in children

Хирургия позвоночника, 2016
Objective. To study the mechanisms of spinal cord injury in children of different age groups. Material and Methods. А retrospective analysis of the results of treatment of 217 children aged 1 to 15 years with trau- matic injuries of the spine and ...
Igor I. Larkin, Valery I. Larkin, Leonid A. Sitko, Aleksandr S. Preobrazhenskiy, Sergey B. Zlobin, Maria M. Katina   +5 more
doaj   +1 more source

TRAUMATISMO RAQUIMEDULAR (TRM). REVISIÓN BIBLIOGRÁFICA

Revista Médica Clínica Las Condes, 2020
Resumen: La complejidad del traumatismo raquimedular (TRM) y su impacto en la vida futura de los pacientes hace necesario actualizar constantemente los protocolos de su manejo. La fisiopatología del TRM hace que la atención prehospitalaria y hospitalaria
Gonzalo Arriagada, Nicolás Macchiavello
doaj   +1 more source

Thermoresponsive Soft and Self‐Anchoring Cuff Electrode for Chronic Peripheral Interfaces

Advanced Functional Materials, EarlyView.
A novel thermoresponsive, soft and self‐anchoring (TSSA) cuff electrode utilizing shape memory polymers achieves autonomous, sutureless peripheral nerve fixation. Driven by thermally induced pre‐strain and tissue adhesion, the device self‐closes and softens at body temperature, successfully minimizing mechanical mismatch. This adaptive platform ensures
Seungjun Lee, Byungwook Park, Jonghee Eun, Sohee Kim, Namsun Chou   +4 more
wiley   +1 more source