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Traumatic spinal cord injury [PDF]

Nature Reviews Disease Primers, 2017
Traumatic spinal cord injury (SCI) has devastating consequences for the physical, social and vocational well-being of patients. The demographic of SCIs is shifting such that an increasing proportion of older individuals are being affected. Pathophysiologically, the initial mechanical trauma (the primary injury) permeabilizes neurons and glia and ...
Christopher S Ahuja, Jefferson R. Wilson, Satoshi Nori, M. Kotter, C. Druschel, A. Curt, M. Fehlings   +6 more
semanticscholar   +5 more sources

Progression in translational research on spinal cord injury based on microenvironment imbalance

Bone Research, 2022
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level and imposes a considerable burden on patients, families, and society. Repair of the injured spinal cord has been recognized as a global medical challenge for many
Baoyou Fan, Zhijian Wei, Shiqing Feng
doaj   +2 more sources

Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging [PDF]

Nature Reviews Neurology, 2019
Pathophysiological changes in the spinal cord white and grey matter resulting from injury can be observed with MRI techniques. These techniques provide sensitive markers of macrostructural and microstructural tissue integrity, which correlate with ...
Gergely Dávid, S. Mohammadi, A. Martin, J. Cohen-Adad, N. Weiskopf, Alan J. Thompson, P. Freund   +6 more
semanticscholar   +3 more sources

Spinal cord injury: molecular mechanisms and therapeutic interventions

Signal Transduction and Targeted Therapy, 2023
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate. The challenges of SCI repair include its complex pathological mechanisms and the difficulties of neural regeneration in the central nervous system.
Xiao Hu, Wei Xu, Yilong Ren, Zhaojie Wang, Xiaolie He, Runzhi Huang, Bei Ma, Jingwei Zhao, Rongrong Zhu, Liming Cheng   +9 more
semanticscholar   +1 more source

Walking naturally after spinal cord injury using a brain–spine interface

Nature, 2023
A reliable digital bridge restored communication between the brain and spinal cord and enabled natural walking in a participant with spinal cord injury. A spinal cord injury interrupts the communication between the brain and the region of the spinal cord
H. Lorach, Andrea Gálvez, Valeria Spagnolo, Félix Martel, Serpil Karakas, Nadine Intering, M. Vat, Olivier Faivre, C. Harte, Salif Komi, Jimmy Ravier, Thibault Collin, Laure Coquoz, Icare Sakr, Edeny Baaklini, Sergio D. Hernandez-Charpak, Grégory Dumont, R. Buschman, Nicholas Buse, T. Denison, I. V. van Nes, L. Asboth, A. Watrin, L. Struber, F. Sauter-Starace, Lilia Langar, V. Auboiroux, S. Carda, S. Chabardès, T. Aksenova, Robin Demesmaeker, G. Charvet, J. Bloch, G. Courtine   +33 more
semanticscholar   +1 more source

Rare case of real-time observation of paralytic deterioration after cervical dislocation in the hyperacute phase

BMC Musculoskeletal Disorders, 2022
Background There have been no prior reports of real-time detailed records leading to complete quadriplegia immediately after fracture dislocation in high-energy trauma. Here, we report a case of cervical dislocation in which the deterioration to complete
Tsutomu Endo, Kota Suda, Takafumi Fukui, Satoko Matsumoto, Miki Komatsu, Masahiro Ota, Chikara Ushiku, Junichi Yamane, Akio Minami, Masahiko Takahata, Norimasa Iwasaki   +10 more
doaj   +1 more source

International Standards for Neurological Classification of Spinal Cord Injury: Revised 2019.

Topics in Spinal Cord Injury Rehabilitation, 2021
This booklet contains the eighth edition of the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) that describes the examination (referred to as the International Standards examination) as well as the classification ...
R. Rupp, F. Biering-Sørensen, S. Burns, D. Graves, J. Guest, L. Jones, M. Read, G. Rodriguez, C. Schuld, Keith E Tansey-Md, K. Walden, S. Kirshblum   +11 more
semanticscholar   +1 more source

Acute Spinal Cord Injury: Correlations and Causal Relations Between Intraspinal Pressure, Spinal Cord Perfusion Pressure, Lactate-to-Pyruvate Ratio, and Limb Power. [PDF]

, 2021
BACKGROUND/OBJECTIVE: We have recently developed monitoring from the injury site in patients with acute, severe traumatic spinal cord injuries to facilitate their management in the intensive care unit.
Hogg, FRA, Kearney, S, Papadopoulos, MC, Saadoun, S, Zoumprouli, A   +4 more
core   +1 more source

Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration

Journal of Neuroinflammation, 2021
Traumatic spinal cord injury (SCI) is a devastating neurological condition that results in a loss of motor and sensory function. Although extensive research to develop treatments for SCI has been performed, to date, none of these treatments have produced
Daniel J. Hellenbrand, Charlie Quinn, Zachariah J. Piper, Carolyn N. Morehouse, J. Fixel, Amgad S. Hanna   +5 more
semanticscholar   +1 more source

Data-driven characterization of walking after a spinal cord injury using inertial sensors

Journal of NeuroEngineering and Rehabilitation, 2023
Background An incomplete spinal cord injury (SCI) refers to remaining sensorimotor function below the injury with the possibility for the patient to regain walking abilities.
Charlotte Werner, Meltem Gönel, Irina Lerch, Armin Curt, László Demkó   +4 more
doaj   +1 more source