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Traumatic spinal cord injury [PDF]

Nature Reviews Disease Primers, 2017
Traumatic spinal cord injury (SCI) has devastating consequences for the physical, social and vocational well-being of patients. The demographic of SCIs is shifting such that an increasing proportion of older individuals are being affected. Pathophysiologically, the initial mechanical trauma (the primary injury) permeabilizes neurons and glia and ...
Jefferson R. Wilson, Mark R. N. Kotter, Michael G. Fehlings, Michael G. Fehlings, Armin Curt, Christopher S. Ahuja, Satoshi Nori, Claudia Druschel   +7 more
openaire   +5 more sources

Progression in translational research on spinal cord injury based on microenvironment imbalance

Bone Research, 2022
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level and imposes a considerable burden on patients, families, and society. Repair of the injured spinal cord has been recognized as a global medical challenge for many
Baoyou Fan, Zhijian Wei, Shiqing Feng
doaj   +2 more sources

Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging [PDF]

Nature Reviews Neurology, 2019
Pathophysiological changes in the spinal cord white and grey matter resulting from injury can be observed with MRI techniques. These techniques provide sensitive markers of macrostructural and microstructural tissue integrity, which correlate with ...
Gergely Dávid, S. Mohammadi, A. Martin, J. Cohen-Adad, N. Weiskopf, Alan J. Thompson, P. Freund   +6 more
semanticscholar   +3 more sources

International Standards for Neurological Classification of Spinal Cord Injury: Revised 2019.

Topics in Spinal Cord Injury Rehabilitation, 2021
This booklet contains the eighth edition of the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) that describes the examination (referred to as the International Standards examination) as well as the classification ...
R. Rupp, F. Biering-Sørensen, S. Burns, D. Graves, J. Guest, L. Jones, M. Read, G. Rodriguez, C. Schuld, Keith E Tansey-Md, K. Walden, S. Kirshblum   +11 more
semanticscholar   +1 more source

Rare case of real-time observation of paralytic deterioration after cervical dislocation in the hyperacute phase

BMC Musculoskeletal Disorders, 2022
Background There have been no prior reports of real-time detailed records leading to complete quadriplegia immediately after fracture dislocation in high-energy trauma. Here, we report a case of cervical dislocation in which the deterioration to complete
Tsutomu Endo, Kota Suda, Takafumi Fukui, Satoko Matsumoto, Miki Komatsu, Masahiro Ota, Chikara Ushiku, Junichi Yamane, Akio Minami, Masahiko Takahata, Norimasa Iwasaki   +10 more
doaj   +1 more source

Acute Spinal Cord Injury: Correlations and Causal Relations Between Intraspinal Pressure, Spinal Cord Perfusion Pressure, Lactate-to-Pyruvate Ratio, and Limb Power. [PDF]

, 2021
BACKGROUND/OBJECTIVE: We have recently developed monitoring from the injury site in patients with acute, severe traumatic spinal cord injuries to facilitate their management in the intensive care unit.
Hogg, FRA, Kearney, S, Papadopoulos, MC, Saadoun, S, Zoumprouli, A   +4 more
core   +1 more source

Data-driven characterization of walking after a spinal cord injury using inertial sensors

Journal of NeuroEngineering and Rehabilitation, 2023
Background An incomplete spinal cord injury (SCI) refers to remaining sensorimotor function below the injury with the possibility for the patient to regain walking abilities.
Charlotte Werner, Meltem Gönel, Irina Lerch, Armin Curt, László Demkó   +4 more
doaj   +1 more source

Targeted Perfusion Therapy in Spinal Cord Trauma. [PDF]

, 2020
We review state-of-the-art monitoring techniques for acute, severe traumatic spinal cord injury (TSCI) to facilitate targeted perfusion of the injured cord rather than applying universal mean arterial pressure targets.
Papadopoulos, MC, Saadoun, S
core   +1 more source

Ang-(1–7)/MasR axis promotes functional recovery after spinal cord injury by regulating microglia/macrophage polarization

Cell & Bioscience, 2023
Background Inflammatory response is an essential part of secondary injury after spinal cord injury (SCI). During this period, the injury may be exacerbated through the release of a large number of inflammatory factors and the polarization of infiltrating
Guangjin Gu, Bin Zhu, Jie Ren, Xiaomeng Song, Baoyou Fan, Han Ding, Jun Shang, Heng Wu, Junjin Li, Hongda Wang, Jinze Li, Zhijian Wei, Shiqing Feng   +12 more
doaj   +1 more source

Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms

International Journal of Molecular Sciences, 2020
Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. Its pathophysiology comprises acute and chronic phases and incorporates a cascade of destructive events such as ...
A. Anjum, Muhammad Da'in Yazid, Muhammad Fauzi Daud, Jalilah Idris, A. M. Ng, Amaramalar Selvi Naicker, Ohnmar Htwe Ismail, Ramesh Kumar Athi Kumar, Y. Lokanathan   +8 more
semanticscholar   +1 more source