Results 21 to 30 of about 710,546 (383)

Effects of gabapentin on muscle spasticity and both induced as well as spontaneous autonomic dysreflexia after complete spinal cord injury

Frontiers in Physiology, 2012
We recently reported that the neuropathic pain medication, gabapentin (GBP; Neurontin), significantly attenuated both noxious colorectal distension (CRD)-induced autonomic dysreflexia (AD) and tail pinch-induced spasticity compared to saline-treated ...
Alexander G. Rabchevsky, Alexander G. Rabchevsky, Samir P. Patel, Travis S. Lyttle, Khalid C. Eldahan, Christopher R. O'Dell, Yi eZhang, Yi eZhang, Phillip G. Popovich, Phillip G. Popovich, Patrick H. Kitzman, Patrick H. Kitzman, Kevin D. Donohue   +12 more
doaj   +1 more source

Opposite modulation of functional recovery following contusive spinal cord injury in mice with oligodendrocyte-selective deletions of Atf4 and Chop/Ddit3

Scientific Reports, 2023
The integrated stress response (ISR)-activated transcription factors ATF4 and CHOP/DDIT3 may regulate oligodendrocyte (OL) survival, tissue damage and functional impairment/recovery in white matter pathologies, including traumatic spinal cord injury (SCI)
Yonglin Gao, George Z. Wei, Michael D. Forston, Benjamin Rood, Emily R. Hodges, Darlene Burke, Kariena Andres, Johnny Morehouse, Christine Armstrong, Charles Glover, Lukasz P. Slomnicki, Jixiang Ding, Julia H. Chariker, Eric C. Rouchka, Sujata Saraswat Ohri, Scott R. Whittemore, Michal Hetman   +16 more
doaj   +1 more source

Traumatic Spinal Cord Injury: An Overview of Pathophysiology, Models and Acute Injury Mechanisms

Frontiers in Neurology, 2019
Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial socioeconomic implications for patients and their care-givers. Recent advances in medical management of SCI has significantly improved diagnosis, stabilization,
Arsalan Alizadeh, Scott Dyck, Soheila Karimi-Abdolrezaee   +2 more
semanticscholar   +1 more source

Calibrated forceps model of spinal cord compression injury. [PDF]

, 2015
Compression injuries of the murine spinal cord are valuable animal models for the study of spinal cord injury (SCI) and spinal regenerative therapy.
Ariza, Jeanelle, Martínez-Cerdeño, Verónica, McDonough, Ashley, Monterrubio, Angela   +3 more
core   +2 more sources

Overground walking patterns after chronic incomplete spinal cord injury show distinct response patterns to unloading

Journal of NeuroEngineering and Rehabilitation, 2018
Background Body weight support (BWS) is often provided to incomplete spinal cord injury (iSCI) patients during rehabilitation to enable gait training before full weight-bearing is recovered.
Christopher Schmidt Easthope, Luca Renato Traini, Lea Awai, Martina Franz, Georg Rauter, Armin Curt, Marc Bolliger   +6 more
doaj   +1 more source

Schwann cell-derived exosomes containing MFG-E8 modify macrophage/microglial polarization for attenuating inflammation via the SOCS3/STAT3 pathway after spinal cord injury

Cell Death and Disease, 2023
Macrophage/microglia polarization acts as an important part in regulating inflammatory responses in spinal cord injury (SCI). However, the regulation of inflammation of Schwann cell-derived exosomes (SCDEs) for SCI repair is still unclear.
Jie Ren, Bin Zhu, Guangjin Gu, Wencan Zhang, Junjin Li, Hongda Wang, Min Wang, Xiaomeng Song, Zhijian Wei, Shiqing Feng   +9 more
doaj   +1 more source

Continuous infusion of an agonist of the tumor necrosis factor receptor 2 in the spinal cord improves recovery after traumatic contusive injury. [PDF]

, 2019
AimThe activation of the TNFR2 receptor is beneficial in several pathologies of the central nervous system, and this study examines whether it can ameliorate the recovery process following spinal cord injury.MethodsEHD2-sc-mTNFR2 , an agonist specific ...
Bethea, John R, Blumenthal, Gary H, Bracchi-Ricard, Valerie, Fischer, Roman, Gerald, Marcus J, Kontermann, Roland E, Moxon, Karen A, Nandakumar, Bharadwaj, Pfizenmaier, Klaus, Ricard, Jerome, Williams, Raushaun   +10 more
core   +2 more sources

Comprehensive Monosynaptic Rabies Virus Mapping of Host Connectivity with Neural Progenitor Grafts after Spinal Cord Injury. [PDF]

, 2017
Neural progenitor cells grafted to sites of spinal cord injury have supported electrophysiological and functional recovery in several studies. Mechanisms associated with graft-related improvements in outcome appear dependent on functional synaptic ...
Adler, Andrew F, Kadoya, Ken, Kumamaru, Hiromi, Lee-Kubli, Corinne, Tuszynski, Mark H   +4 more
core   +2 more sources

Robotic body weight support enables safe stair negotiation in compliance with basic locomotor principles

Journal of NeuroEngineering and Rehabilitation, 2019
Background After a neurological injury, mobility focused rehabilitation programs intensively train walking on treadmills or overground. However, after discharge, quite a few patients are not able to independently negotiate stairs, a real-world task with ...
M. Bannwart, E. Rohland, C. A. Easthope, G. Rauter, M. Bolliger   +4 more
doaj   +1 more source

Investigation of perfusion impairment in degenerative cervical myelopathy beyond the site of cord compression

Scientific Reports, 2023
The aim of this study was to determine tissue-specific blood perfusion impairment of the cervical cord above the compression site in patients with degenerative cervical myelopathy (DCM) using intravoxel incoherent motion (IVIM) imaging.
Anna Lebret, Simon Lévy, Nikolai Pfender, Mazda Farshad, Franziska C. S. Altorfer, Virginie Callot, Armin Curt, Patrick Freund, Maryam Seif   +8 more
doaj   +1 more source