Results 261 to 270 of about 55,024 (303)

Spinal Cord Injury and Assays for Regeneration

2023
Due to their renowned regenerative capacity, adult zebrafish are a premier vertebrate model to interrogate mechanisms of innate spinal cord regeneration. Following complete transection to their spinal cord, zebrafish extend glial and axonal bridges across severed tissue, regenerate neurons proximal to the lesion, and regain swim capacity within 8 weeks
Brooke, Burris, Mayssa H, Mokalled
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Stem cells and spinal cord regeneration

Current Opinion in Biotechnology, 2009
Cell-based transplantation strategies are inherently combination therapies, as they may mediate spinal cord repair via trophic or phenotypic mechanisms. The growth factor expression profile and phenotype of transplanted cells are determined by the transplant population as well as by the site into which they are transplanted.
Sharyn L, Rossi, Hans S, Keirstead
openaire   +2 more sources

Dissecting spinal cord regeneration

Nature, 2018
The inability to recover functions lost after severe spinal cord injury has been recognized for millennia and was first attributed to a failure of spinal cord neural regeneration over 100 years ago. The last forty years have seen intense research into achieving such regeneration, but in spite of conceptual advances and many reports announcing ...
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ADVANCES AND STRATEGIES FOR SPINAL CORD REGENERATION

Orthopedic Clinics of North America, 2000
Although a cure for spinal cord injuries does not currently exist, advances have been made in the field of spinal cord regeneration. This article discusses the pathophysiology of spinal cord injury, animal models, and strategies for restoration and regeneration of the spinal cord.
F P, Girardi, S N, Khan, F P, Cammisa, T J, Blanck   +3 more
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Stimulating regeneration in the damaged spinal cord

Journal of Physiology-Paris, 2002
Great progress has been made in recent years in experimental strategies for spinal cord repair. In this review we describe two of these strategies, namely the use of neurotrophic factors to promote functional regeneration across the dorsal root entry zone (DREZ), and the use of synthetic fibronectin conduits to support directed axonal growth.
Priestley, J V, Ramer, M S, King, V R, McMahon, S B, Brown, R A   +4 more
openaire   +3 more sources

Spinal cord regeneration in Xenopus laevis

Nature Protocols, 2017
Here we present a protocol for the husbandry of Xenopus laevis tadpoles and froglets, and procedures to study spinal cord regeneration. This includes methods to induce spinal cord injury (SCI); DNA and morpholino electroporation for genetic studies; in vivo imaging for cell analysis; a swimming test to measure functional recovery; and a convenient ...
Edwards Faret, Gabriela Andrea, Valle Muñoz Videla, Rosana del, Mendez Olivos, Emilio E., Lee-Liu, Dasfne, Tapia, Victor S., Larraín Correa, Juan Agustín   +5 more
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Scaffolds to promote spinal cord regeneration

2012
Substantial research effort in the spinal cord injury (SCI) field is directed towards reduction of secondary injury changes and enhancement of tissue sparing. However, pathway repair after complete transections, large lesions, or after chronic injury may require the implantation of some form of oriented bridging structure to restore tissue continuity ...
S, Sakiyama-Elbert, P J, Johnson, S I, Hodgetts, G W, Plant, A R, Harvey   +4 more
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Elimination of root regeneration in studies of spinal cord regeneration

Surgical Neurology, 1983
In experimental studies of spinal cord regeneration, dorsal root regeneration can be erroneously interpreted as regeneration of the central axons. The present study explored the possibility of eliminating root regeneration by preliminary bilateral division of the L-1 and L-2 roots. Clinical performance as measured by the inclined plane technique showed
C H, Tator, A S, Rivlin
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Regeneration in the Cord of Spinal Monkeys

Neurology, 1956
W F, WINDLE, J L, LITTRELL, J O, SMART, J, JORALEMON   +3 more
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Spinal cord regeneration in zebrafish

Science, 2016
Neuroregeneration Unlike humans, zebrafish can regenerate their spinal cord. Mokalled et al. identified a growth factor in zebrafish that helps this process (see the Perspective by Williams and He). The protein encoded by ctgfa ( connective tissue growth factor a ) is secreted after injury and encourages glial cells to form a bridge across the spinal ...
openaire   +1 more source