Results 61 to 70 of about 55,024 (303)

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

An interactive 3-D application for pain management: Results from a pilot study in spinal cord injury rehabilitation

, 2012
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2012 ElevierResearch on pain following spinal cord injury (SCI) has revealed that patients not only experience several types ...
Gawronski, J, Frank, AO, Spyridonis, F, Ghinea, G   +3 more
core   +1 more source

The blood-tendon barrier: identification and characterisation of a novel tissue barrier in tendon blood vessels [PDF]

European Cells & Materials, 2016
Tissue barriers function as “gate keepers” between different compartments (usually blood and tissue) and are formed by specialised membrane-associated proteins, localising to the apicolateral plasma membrane domain of epithelial and endothelial cells. By
C Lehner, R Gehwolf, JC Ek, S Korntner, H Bauer, H-C Bauer, A Traweger, H Tempfer   +7 more
doaj   +1 more source

Spinal cord regeneration

The Indian Journal of Neurotrauma, 2010
Research in spinal cord regeneration is catching attention of clinicians and basic scientists. It would almost revolutionise the life and disease outcome of these unfortunate patients if we can work out a cost effective and practical treatment regimen for these victims who are unfortunately in the prime of their productive years.
openaire   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

AMPK controls the axonal regenerative ability of dorsal root ganglia sensory neurons after spinal cord injury.

, 2020
Regeneration after injury occurs in axons that lie in the peripheral nervous system but fails in the central nervous system, thereby limiting functional recovery.
Puttagunta, Radhika, Palmisano, Ilaria, Freiwald, Anja, Serger, Elisabeth, De Virgiliis, Francesco, La Montanara, Paolo, Shkura, Kirill, Zhou, Luming, Kong, Guiping, Di Giovanni, Simone, Mclachlan, Eilidh, Hutson, Thomas H   +11 more
core   +1 more source

Role of the innate immune system in the regeneration of the zebrafish larvae spinal cord [PDF]

, 2019
Spinal cord injury leads to an increased response of innate immune cells (microglia, macrophages, neutrophils) in non-regenerating mammals and in successfully regenerating zebrafish.
Tsarouchas, Themistoklis
core   +1 more source

Enhancing Maturation of Human Neuromuscular Organoids via Electrical Stimulation

Advanced Science, EarlyView.
A framework for on‐demand and non‐invasive exposure of human neuromuscular organoids (NMOs) to electrical stimuli is established to promote their maturation. The robustness and effectiveness of different stimulation regimes are evaluated via thorough characterization of organoid tissue structure and contraction capacity. Chronic electrical stimulation,
Chrysanthi‐Maria Moysidou, Inês Afonso Martins, Ismail Amr El‐Shimy, Iacopo Bicci, Donatella Cea, Christina Bukas, Isra Mekki, Mara‐Camelia Rusu, Aylin Nebol, Ines Lahmann, Marie Piraud, Enrico Klotzsch, Mina Gouti   +12 more
wiley   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Electrical activity suppresses intrinsic growth competence in adult primary sensory neurons [PDF]

, 2009
The ability of neurons to regenerate in the adult mammalian central nervous system (CNS) is often poor, leading to persistent deficits after injury. Failure of axon regeneration in the CNS has been attributed to the presence of an extrinsic inhibitory ...
Enes, Joana
core