Results 161 to 170 of about 412,161 (357)

Disruption of ARID1B Recruitment to the Nuclear Pore Complex as a New Anticancer Therapeutic Strategy

open access: yesAdvanced Science, EarlyView.
This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz   +14 more
wiley   +1 more source

Dual motion valve with single motion input [PDF]

open access: yes, 1987
A dual motion valve includes two dual motion valve assemblies with a rotary input which allows the benefits of applying both rotary and axial motion to a rotary sealing element with a plurality of ports.
Belew, Robert
core   +1 more source

The effect of different amounts of spindle tuber and leaf roll on yields of Irish potato [PDF]

open access: bronze, 1944
E. L. LeClerg   +4 more
openalex   +1 more source

Engineered Foxp1high Exosomes Ameliorates Systemic Lupus Erythematosus

open access: yesAdvanced Science, EarlyView.
This study presents a dual‐engineering strategy combining mesenchymal stem cell aggregation and Foxp1 overexpression to generate Foxp1high aggregation exosomes with enhanced immunomodulatory properties. These engineered exosomes exhibit immune organ targeting and superior efficacy in systemic lupus erythematosus treatment by promoting Treg ...
Luhan Niu   +9 more
wiley   +1 more source

A Mitochondria‐Targeted Nanozyme Platform for Multi‐Pathway Tumor Therapy via Ferroptosis and Cuproptosis Regulation

open access: yesAdvanced Science, EarlyView.
This work reports a mitochondria‐targeted nanozyme platform, MIL‐Cu1.8S‐TPP/FA, which induces potent cuproptosis via localized delivery of Cu1.8S nanodots to mitochondria. Surface‐anchoring these nanodots onto MIL‐88B metal‐organic frameworks enhances both passive and active tumor targeting.
Chenguang Liu   +8 more
wiley   +1 more source

Spindle centricity [PDF]

open access: yesCell Cycle, 2011
Andrew D, McAinsh, Anne, Straube
openaire   +2 more sources

Calcitonin Gene‐Related Peptide (CGRP)‐Expressing Neurons in the External Lateral Parabrachial Area Regulate Pain‐Induced Sleep Disturbances

open access: yesAdvanced Science, EarlyView.
Lynch et al., identified novel targets on the wake‐promoting pathways that can effectively treat pain‐induced sleep disturbances. The authors demonstrated that Calcitonin gene‐related peptide‐expressing neurons (CGRP) in the external lateral parabrachial nucleus (PBelCGRP) serve as the primary relay node for pain stimuli that cause sleep disruption ...
Nicole Lynch   +13 more
wiley   +1 more source

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