Results 191 to 200 of about 562,858 (399)
Regulation of mitotic spindle orientation: an integrated view
EMBO Reports, 2016 Florencia di Pietro, A. Echard, X. Morin
semanticscholar +1 more source
Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections
Advanced Science, EarlyView.This review highlights the dynamic plasticity of macrophages during pulmonary infections and proposes an integrative framework defining six functional subtypes: Inflam‐Ms, Hub‐Ms, Reg‐Ms, Prolif‐Ms, Memory‐Ms, and Senesc‐Ms. Single‐cell omics delineate their distinct roles in homeostasis and infection, refining our understanding of macrophage ...
Zhaoheng Lin +3 more
wiley +1 more source
Parabiosis, Assembloids, Organoids (PAO)
Advanced Science, EarlyView.This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong +5 more
wiley +1 more source
Advanced Science, EarlyView.This study investigates the role of PACS‐2 in IDD, demonstrating that it suppresses the nuclear translocation of SP1, thereby downregulating its downstream target LRRK2. This reduces LRRK2‐mediated ubiquitination and degradation of Mfn2 through the JNK pathway, preserving MAM integrity and promoting NPSC survival.
Liang Kang +19 more
wiley +1 more source
Chemically Driven Nano‐Elastic Heterogeneities Control Fragility in Volcanic Melts
Advanced Science, EarlyView.The study elucidates how nanoscale structural heterogeneity governs the mechanical behavior of volcanic glasses across compositions from basalt to rhyolite. Using a physicochemical framework, correlation length (ξ) and microscopic free volume (Vc) are derived from vibrational and physical properties, revealing systematic trends with silica content that
Michele Cassetta +13 more
wiley +1 more source
Mechanisms of Mitotic Spindle Assembly.
Annual Review of Biochemistry, 2016 Sabine Petry
semanticscholar +1 more source
Advanced Science, EarlyView.Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Peiying Zhang +8 more
wiley +1 more source
Thalamic Dysfunction in Schizophrenia Suggested by Whole-Night Deficits in Slow and Fast Spindles
, 2010 Fabio Ferrarelli +8 more
openalex +2 more sources