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Antibodies to Mitotic Spindle Apparatus: Clinical Significance of NuMA and HsEg5 Autoantibodies
Journal of Clinical Immunology, 2008The clinical associations of NuMA and HsEg5 antibodies, the main anti-mitotic spindle apparatus autoantibodies, remain unclear due to their extremely low prevalence.We have analysed the clinical data of 40 anti-NuMA- (0.87 per thousand) and 7 anti-HsEg5- (0.15 per thousand) positive patients detected during routine immunofluorescence examination of 45 ...
Lourdes, Mozo +2 more
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Simultaneous Staining of the Spindle Apparatus and Constitutive Heterochromatin
Stain Technology, 1974In nonhypotonically treated mitoses from tissue cultures grown on cover glasses, the constitutive heterochromatin as well as the spindle apparatus can be stained by a Giemsa technique for demonstrating repetitive DNA. Cells were treated with 0.015 M sodium chloride and 0.0015 M sodium citrate at 92 C for about 3 min, then with 03 M sodium chloride and ...
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Cytokinesis: relative alignment of the cell division apparatus and the mitotic spindle
Current Opinion in Cell Biology, 2003The cell division apparatus is assembled at different stages of the cell cycle in different eukaryotic organisms. Mechanisms exist in all organisms, however, to ensure that the cell division apparatus and the mitotic spindle are aligned perpendicular to each other.
Wang, Hongyan +2 more
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Evaluation of the meiotic spindle apparatus in oocytes undergoing intracytoplasmic sperm injection
Fertility and Sterility, 1995To determine whether intracytoplasmic sperm injection has an adverse effect on the meiotic spindle of oocytes after injection of a sperm into the ooplasm.Hamster oocytes were injected with human sperm (Test group) and evaluated for meiotic spindle and chromosome morphology using immunofluorescent staining.
Y, Asada +3 more
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Evaluation of the spindle apparatus of in-vitro matured human oocytes following cryopreservation
Human Reproduction, 1995The present study was conducted to determine if the cryopreservation of immature human oocytes has a deleterious effect on the meiotic spindle following maturation in vitro. Oocytes were obtained in excess from in-vitro fertilization patients and divided into four groups.
S G, Baka +5 more
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Protoplasma, 1974
Microtubules (MTs) are the most prominent structural elements of the spindle apparatus. Consequently they are generally thought to a play a role in the processes of spindle elongation and the autonomous chromosome movements towards the spindle poles in anaphase.
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Microtubules (MTs) are the most prominent structural elements of the spindle apparatus. Consequently they are generally thought to a play a role in the processes of spindle elongation and the autonomous chromosome movements towards the spindle poles in anaphase.
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Antibody to the mitotic spindle apparatus: immunologic characteristics and cytologic studies.
The Journal of rheumatology, 1984A naturally occurring autoantibody directed at the mitotic spindle polar apparatus (MSA) was detected in sera from 18 patients with defined or evolving connective tissue diseases by routine indirect immunofluorescence on a tissue culture cell. This IgG antibody stained the mitotic spindle poles of dividing tissue culture and tissue section substrates ...
G A, McCarty +2 more
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Principles and dynamics of spindle assembly checkpoint signalling
Nature Reviews Molecular Cell Biology, 2023Andrew D Mcainsh, Geert J P L Kops
exaly
Spindle positioning and its impact on vertebrate tissue architecture and cell fate
Nature Reviews Molecular Cell Biology, 2021Terry Lechler, Marina Mapelli
exaly