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The spindle-assembly checkpoint in space and time
Nature Reviews Molecular Cell Biology, 2007 In eukaryotes, the spindle-assembly checkpoint (SAC) is a ubiquitous safety device that ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome mis-segregation and aneuploidy, and its dysfunction is implicated in tumorigenesis. Recent molecular analyses have begun to shed light on the complex interaction of the checkpoint
Andrea Musacchio +2 more
exaly +6 more sources
Spindle assembly checkpoint: the third decade [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2011 The spindle assembly checkpoint controls cell cycle progression during mitosis, synchronizing it with the attachment of chromosomes to spindle microtubules. After the discovery of themitotic arrest deficient(MAD) andbudding uninhibited by benzymidazole(BUB) genes as crucial checkpoint components in 1991, the second decade of checkpoint studies (2001 ...
Andrea Musacchio
exaly +5 more sources
A quantitative systems view of the spindle assembly checkpoint [PDF]
EMBO Journal, 2009 The idle assembly checkpoint acts to delay chromosome segregation until all duplicated sister chromatids are captured by the mitotic spindle. This pathway ensures that each daughter cell receives a complete copy of the genome. The high fidelity and robustness of this process have made it a subject of intense study in both the experimental and ...
Andrea Ciliberto, Jagesh V Shāh
exaly +7 more sources
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Principles and dynamics of spindle assembly checkpoint signalling
Nature Reviews Molecular Cell Biology, 2023The transmission of a complete set of chromosomes to daughter cells during cell division is vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) ensures correct segregation by informing the cell cycle machinery of potential errors in the interactions of chromosomes with spindle microtubules prior to anaphase.
A. McAinsh, G. Kops
semanticscholar +4 more sources
The spindle assembly checkpoint
Current Opinion in Cell Biology, 1996The spindle assembly checkpoint monitors proper chromosome attachment to spindle microtubules and is conserved from yeast to humans. Checkpoint components reside on kinetochores of chromosomes and show changes in phosphorylation and localization as cells proceed through mitosis.
A D, Rudner, A W, Murray
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The Spindle Assembly and Spindle Position Checkpoints
Annual Review of Genetics, 2003▪ Abstract The mitotic spindle segregates chromosomes to opposite ends of the cell in preparation for cell division. Chromosome attachment to the spindle is monitored by the spindle assembly checkpoint, and at least in yeast cells, penetration of one spindle pole into the bud is monitored by the spindle position checkpoint.
Daniel J, Lew, Daniel J, Burke
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Reproductive Toxicology, 2020
Cadmium (Cd) is a bioaccumulative heavy metal element with potential toxicity on the female reproductive system, but the exact molecular mechanisms have not yet been clearly defined.
Feng Dong +9 more
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Cadmium (Cd) is a bioaccumulative heavy metal element with potential toxicity on the female reproductive system, but the exact molecular mechanisms have not yet been clearly defined.
Feng Dong +9 more
semanticscholar +1 more source
Spindle-Assembly Checkpoint and Gastrointestinal Cancer
New England Journal of Medicine, 2011To the Editor: Rio Frio et al. (Dec. 30 issue)1 report on a germline homozygous mutation in the spindle-assembly checkpoint gene BUB1B in a patient with a nonclassic form of the mosaic variegated aneuploidy syndrome, resulting in reduced expression, increased levels of constitutive aneuploidy, and multiple gastrointestinal neoplasms starting at 34 ...
de Voer, R.M. +3 more
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Cdh1 is an antagonist of the spindle assembly checkpoint
Cellular Signalling, 2014The spindle assembly checkpoint (SAC) monitors unsatisfied connections of microtubules to kinetochores and prevents anaphase onset by inhibition of the ubiquitin ligase E3 anaphase-promoting complex or cyclosome (APC/C) in association with the activator Cdc20.
Masayoshi, Nagai, Takashi, Ushimaru
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