Results 231 to 240 of about 36,138 (257)
Some of the next articles are maybe not open access.
Slipping past the spindle assembly checkpoint
Nature Cell Biology, 2013Error-free genome segregation depends on the spindle assembly checkpoint (SAC), a signalling network that delays anaphase onset until chromosomes have established proper spindle attachments. Three reports now quantitatively examine the sensitivity and robustness of the SAC response.
Radhika, Subramanian, Tarun M, Kapoor
openaire +2 more sources
The spindle assembly checkpoint in budding yeast
1997Publisher Summary This chapter discusses the spindle assembly checkpoint in budding yeast. As cells proceed through cycles of growth and division they are often challenged by environmental insult and injury as well as spontaneous errors in cellular processes. The response to cell damage requires that cells sense the damage, arrest the cell cycle, and
A F, Straight, A W, Murray
openaire +2 more sources
Sister chromatid tension and the spindle assembly checkpoint
Current Opinion in Cell Biology, 2009The spindle assembly checkpoint (SAC) is a feedback control system that monitors the state of kinetochore/microtubule attachment during mitosis and halts cell cycle progression until all chromosomes are properly aligned at the metaphase plate. The state of chromosome-microtubule attachment is implicated as a crucial factor in the checkpoint response ...
Nezi, Luigi, Musacchio, Andrea
openaire +3 more sources
Adaptation of the spindle-assembly checkpoint
2019Antimicrotubule agents are commonly used chemotherapeutic agents that kill cancer cells by activating the spindle assembly checkpoint (SAC). However, some cancer cells can adapt to the checkpoint and exit mitosis without chromosome segregation.
openaire +2 more sources
Spindle assembly checkpoint gene BUB1B is essential in breast cancer cell survival
Breast Cancer Research and Treatment, 2020Dilara Koyuncu +3 more
semanticscholar +1 more source
Analysis of the Spindle-Assembly Checkpoint in HeLa Cells
2004The spindle-assembly checkpoint involves signaling at kinetochores, which leads to the arrest of mitotic progression in the absence of microtubule attachment or spindle tension. Here, we detail procedures for the analysis of the spindle-assembly checkpoint in adherent mammalian cells.
Paul R, Andreassen +2 more
openaire +2 more sources
Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore
Nature Reviews Molecular Cell Biology, 2012Emily A Foley +2 more
exaly
Molecular Regulation of the Spindle Assembly Checkpoint by Kinases and Phosphatases.
International Review of Cell and Molecular Biology, 2017G. Manic +4 more
semanticscholar +1 more source
Ablation of the spindle assembly checkpoint by a compound targeting Mps1
EMBO Reports, 2005Marc Schmidt
exaly