Results 11 to 20 of about 34,560 (199)

Cellular Senescence in Intervertebral Disc Aging and Degeneration: Molecular Mechanisms and Potential Therapeutic Opportunities

Biomolecules, 2023
Closely associated with aging and age-related disorders, cellular senescence (CS) is the inability of cells to proliferate due to accumulated unrepaired cellular damage and irreversible cell cycle arrest.
Prashanta Silwal, Allison M. Nguyen-Thai, Haneef Ahamed Mohammad, Yanshan Wang, Paul D. Robbins, Joon Y. Lee, Nam V. Vo   +6 more
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Spines and homologues in ‘araphid’ diatoms [PDF]

Plant Ecology and Evolution, 2019
Background and aims – Many diatoms have spines on the surface of their valves. These structures differ from one taxon to another. Are all these spines the same? Are they homologues of one another?
David M Williams
doaj   +3 more sources

Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP/CHSY1 Axis

Advanced Science, 2022
Sensory nerves are long being recognized as collecting units of various outer stimuli; recent advances indicate that the sensory nerve also plays pivotal roles in maintaining organ homeostasis.
Bo Hu, Xiao Lv, Leixin Wei, Yunhao Wang, Genjiang Zheng, Chen Yang, Fazhi Zang, Jianxi Wang, Jing Li, Xiaodong Wu, Zhihao Yue, Qiangqiang Xiao, Zengwu Shao, Wen Yuan, Jinsong Li, Peng Cao, Chen Xu, Huajiang Chen   +17 more
doaj   +1 more source

The temporal and spatial expression of sclerostin and Wnt signaling factors during the maturation of posterolateral lumbar spine fusions

JOR Spine, 2021
The bone healing environment in the posterolateral spine following arthrodesis surgery is one of the most challenging in all of orthopedics and our understanding of the molecular signaling pathways mediating osteogenesis during spinal fusion is limited ...
John Rodriguez‐Feo, Lorenzo Fernandes, Anuj Patel, Thanh Doan, Scott D. Boden, Hicham Drissi, Steven M. Presciutti   +6 more
doaj   +1 more source

Induction of Skeletal Muscle Injury by Intramuscular Injection of Cardiotoxin in Mouse

Bio-Protocol, 2023
Skeletal muscle is the most abundant tissue in the human body and has a tremendous capability to regenerate in response to muscle injuries and diseases. Induction of acute muscle injury is a common method to study muscle regeneration in vivo. Cardiotoxin
Xin Fu, Sheng Li, Minzhi Jia, Wenjun Yang, Ping Hu   +4 more
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Elevated Antibody Titers to Epstein–Barr Virus and Cytomegalovirus in Patients with Drug-Induced Lupus

Viruses, 2023
Systemic lupus erythematosus (SLE) is an autoimmune disease, which has been associated with Epstein–Barr virus (EBV) and Cytomegalovirus (CMV) infection.
Julie Knudsen, Nicole Hartwig Trier, Anette Holck Draborg, Christoffer Tandrup Nielsen, Søren Jacobsen, Peter Højrup, Gunnar Houen   +6 more
doaj   +1 more source

Multimodal pathophysiological dataset of gradual cerebral ischemia in a cohort of juvenile pigs

Scientific Data, 2021
Measurement(s) EEG with persistent abnormal rhythmic activity • electrocardiogram • Electrothalamogram • cerebral blood flow measurement • positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure •
Martin G. Frasch, Bernd Walter, Christophe L. Herry, Reinhard Bauer   +3 more
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Artesunate Regulates Neurite Outgrowth Inhibitor Protein B Receptor to Overcome Resistance to Sorafenib in Hepatocellular Carcinoma Cells

Frontiers in Pharmacology, 2021
The multireceptor tyrosine kinase inhibitor sorafenib is a Food and Drug Administration-approved first-line drug for the treatment of advanced liver cancer that can reportedly extend overall survival in patients with advanced hepatocellular carcinoma ...
Wubin He, Xiaoxu Huang, Bradford K. Berges, Yue Wang, Ni An, Rongjian Su, Yanyan Lu   +6 more
doaj   +1 more source

Hypoxia-sensitive long noncoding RNA CASC15 promotes lung tumorigenesis by regulating the SOX4/β-catenin axis

Journal of Experimental & Clinical Cancer Research, 2021
Background Accumulating evidence has demonstrated that long non-coding RNAs (lncRNAs) are involved in the hypoxia-related cancer process and play pivotal roles in enabling malignant cells to survive under hypoxic stress.
Jianyong Sun, Yanlu Xiong, Kuo Jiang, Bo Xin, Tongtong Jiang, Renji Wei, Yuankang Zou, Hong Tan, Tao Jiang, Angang Yang, Lintao Jia, Lei Wang   +11 more
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First person – Hao Lu

Biology Open, 2020
First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers.
doaj   +1 more source