A Dynamic Model of Interactions of Ca^(2+), Calmodulin, and Catalytic Subunits of Ca^(2+)/Calmodulin-Dependent Protein Kinase II [PDF]
, 2010 During the acquisition of memories, influx of Ca^(2+) into the postsynaptic spine through the pores of activated N-methyl-D-aspartate-type glutamate receptors triggers processes that change the strength of excitatory synapses.
A Hoelz +60 more
core +7 more sources
Biomolecules, 2023 Closely associated with aging and age-related disorders, cellular senescence (CS) is the inability of cells to proliferate due to accumulated unrepaired cellular damage and irreversible cell cycle arrest.
Prashanta Silwal +6 more
doaj +1 more source
Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP/CHSY1 Axis
Advanced Science, 2022 Sensory nerves are long being recognized as collecting units of various outer stimuli; recent advances indicate that the sensory nerve also plays pivotal roles in maintaining organ homeostasis.
Bo Hu +17 more
doaj +1 more source
JOR Spine, 2021 The bone healing environment in the posterolateral spine following arthrodesis surgery is one of the most challenging in all of orthopedics and our understanding of the molecular signaling pathways mediating osteogenesis during spinal fusion is limited ...
John Rodriguez‐Feo +6 more
doaj +1 more source
Induction of Skeletal Muscle Injury by Intramuscular Injection of Cardiotoxin in Mouse
Bio-Protocol, 2023 Skeletal muscle is the most abundant tissue in the human body and has a tremendous capability to regenerate in response to muscle injuries and diseases. Induction of acute muscle injury is a common method to study muscle regeneration in vivo. Cardiotoxin
Xin Fu +4 more
doaj +1 more source
Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1 [PDF]
, 2016 Brief periods of sleep loss have long-lasting consequences such as impaired memory consolidation. Structural changes in synaptic connectivity have been proposed as a substrate of memory storage.
Abel, Ted +14 more
core +5 more sources
The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning. [PDF]
, 2017 Neuronal ApoE receptors are linked to learning and memory, but the pathways governing their abundance, and the mechanisms by which they affect the function of neural circuits are incompletely understood.
Achiro, Jennifer M +9 more
core +3 more sources
Viruses, 2023 Systemic lupus erythematosus (SLE) is an autoimmune disease, which has been associated with Epstein–Barr virus (EBV) and Cytomegalovirus (CMV) infection.
Julie Knudsen +6 more
doaj +1 more source
The malleable brain: plasticity of neural circuits and behavior: A review from students to students [PDF]
, 2017 One of the most intriguing features of the brain is its ability to be malleable, allowing it to adapt continually to changes in the environment. Specific neuronal activity patterns drive long-lasting increases or decreases in the strength of synaptic ...
Adeniyi, Philip A. +32 more
core +2 more sources
Multimodal pathophysiological dataset of gradual cerebral ischemia in a cohort of juvenile pigs
Scientific Data, 2021 Measurement(s) EEG with persistent abnormal rhythmic activity • electrocardiogram • Electrothalamogram • cerebral blood flow measurement • positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure •
Martin G. Frasch +3 more
doaj +1 more source