Results 21 to 30 of about 104,174 (256)

The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]

, 2012
A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Corrêa, Sônia A. L., Eales, Katherine L.   +1 more
core   +3 more sources

Activation of tyrosine kinases by mutation of the gatekeeper threonine. [PDF]

, 2008
Protein kinases targeted by small-molecule inhibitors develop resistance through mutation of the gatekeeper threonine residue of the active site. Here we show that the gatekeeper mutation in the cellular forms of c-ABL, c-SRC, platelet-derived growth ...
Azam, Mohammad, Daley, George, Gray, Nathanael, KURIYAN, John, Seeliger, Markus   +4 more
core   +1 more source

First person – Hao Lu

Biology Open, 2020
First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers.
doaj   +1 more source

Hypoxia-sensitive long noncoding RNA CASC15 promotes lung tumorigenesis by regulating the SOX4/β-catenin axis

Journal of Experimental & Clinical Cancer Research, 2021
Background Accumulating evidence has demonstrated that long non-coding RNAs (lncRNAs) are involved in the hypoxia-related cancer process and play pivotal roles in enabling malignant cells to survive under hypoxic stress.
Jianyong Sun, Yanlu Xiong, Kuo Jiang, Bo Xin, Tongtong Jiang, Renji Wei, Yuankang Zou, Hong Tan, Tao Jiang, Angang Yang, Lintao Jia, Lei Wang   +11 more
doaj   +1 more source

Artesunate Regulates Neurite Outgrowth Inhibitor Protein B Receptor to Overcome Resistance to Sorafenib in Hepatocellular Carcinoma Cells

Frontiers in Pharmacology, 2021
The multireceptor tyrosine kinase inhibitor sorafenib is a Food and Drug Administration-approved first-line drug for the treatment of advanced liver cancer that can reportedly extend overall survival in patients with advanced hepatocellular carcinoma ...
Wubin He, Xiaoxu Huang, Bradford K. Berges, Yue Wang, Ni An, Rongjian Su, Yanyan Lu   +6 more
doaj   +1 more source

The Generation Of Novelty: The Province Of Developmental Biology [PDF]

, 2006
A response to Michael Ruse\u27s Forty Years A Philosopher Of Biology: Why EvoDevo Makes Me Still Excited About My Subject
Gilbert, Scott F.
core   +2 more sources

The combination of three-dimensional and rotary cell culture system promotes the proliferation and maintains the differentiation potential of rat BMSCs

Scientific Reports, 2017
Bone marrow mesenchymal stem cells (BMSCs) are a good candidate for tissue engineering and clinical application. One of the challenges in its cell therapy is how to quickly obtain an adequate number of seed cells and meanwhile maintain suitable ...
Yilong Tang, Yan Xu, Zhifeng Xiao, Yannan Zhao, Jing Li, Sufang Han, Lei Chen, Bin Dai, Ling Wang, Bing Chen, Hong Wang   +10 more
doaj   +1 more source

Update to the dataset of cerebral ischemia in juvenile pigs with evoked potentials

Scientific Data, 2021
Measurement(s) Abnormal auditory evoked potentials • Abnormality of somatosensory evoked potentials • high frequency oscillations • brain activity Technology Type(s) Electrocorticography • electrothalamography Factor Type(s) anesthesia • analgosedation •
Martin G. Frasch, Bernd Walter, Christoph Anders, Reinhard Bauer   +3 more
doaj   +1 more source

Active elastohydrodynamics of vesicles in narrow, blind constrictions [PDF]

, 2017
Fluid-resistance limited transport of vesicles through narrow constrictions is a recurring theme in many biological and engineering applications. Inspired by the motor-driven movement of soft membrane-bound vesicles into closed neuronal dendritic spines,
Fai, Thomas G., Harting, Jens, Kusters, Remy, Mahadevan, L., Rycroft, Chris H.   +4 more
core   +4 more sources

Sa12b-Modified Functional Self-Assembling Peptide Hydrogel Enhances the Biological Activity of Nucleus Pulposus Mesenchymal Stem Cells by Inhibiting Acid-Sensing Ion Channels

Frontiers in Cell and Developmental Biology, 2022
Various hydrogels have been studied for nucleus pulposus regeneration. However, they failed to overcome the changes in the acidic environment during intervertebral disc degeneration.
Letian Han, Letian Han, Ziyu Wang, Haoyu Chen, Haoyu Chen, Jie Li, Shengquan Zhang, Sumei Zhang, Shanzhong Shao, Shanzhong Shao, Yinshun Zhang, Yinshun Zhang, Cailiang Shen, Cailiang Shen, Hui Tao, Hui Tao   +15 more
doaj   +1 more source