Results 131 to 140 of about 349,637 (309)

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Passive surgical correction of rigid adult spine deformities to normative alignment and balance

Scientific Reports
Realizing an age-adjusted correction in adult spine deformities (ASD) is demanding. We focus on rigid ASD patients requiring three-column osteotomies (TCO) and analyze the capability to obtain a normative alignment.
Crescenzo Capone, Tobias Pötzel, Denis Bratelj, Marcel Rudnick, Rajeev K. Verma, Michael Fiechter   +5 more
doaj   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Anterolateral versus posterior minimally invasive interbody fusion for patients with spondylolisthesis: 12 months follow-up

Brain and Spine, 2021
Yann Philippe Charles, Paulo Pereira, Carlos Santos, Yung Park, Vasileios Arzoglou, Seung-Won Park, Wolfgang Senker, Jörg Franke, Gerd Bordon, Stephane Fuentes, Yueming Song, Emiliano Vialle, Shaishav Bhagat, Neil Manson, Aleksandr Krutko   +14 more
doaj   +1 more source

Machine learning integration of multi-modal radiomics and clinical factors predicts refracture risk after percutaneous kyphoplasty in postmenopausal women

Scientific Reports
This study explores the use of radiomic features extracted from preoperative T2-weighted MRI and CT images, combined with machine learning models, to predict the risk of vertebral refracture after percutaneous kyphoplasty (PKP) in postmenopausal women ...
Bin Zheng, Panfeng Yu, Zhenqi Zhu, Yan Liang, Haiying Liu   +4 more
doaj   +1 more source

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

Clinical Insights on Transforaminal Lumbar Interbody Fusion (TLIF) Implantations Following Spinal Fusion Surgery: Enhancing and Monitoring Bone Health in Patients

Orthopedic Research and Reviews
Francesco Puglia,1 Marcello Ferraro,2 Valentina Longhi,2,3 Enrico Gallazzi,2 Giovanni Andrea La Maida2 1Specialized Unit of Pediatric Orthopedics and Traumatology, ASST Gaetano Pini/CTO, Milan, Italy; 2Specialized Unit of Spinal Disorders and Scoliosis ...
Puglia F, Ferraro M, Longhi V, Gallazzi E, La Maida GA   +4 more
doaj  

Minimally invasive approaches for lumbar interbody fusion surgery in adults suffering from degenerative lumbar disease: Real world data at 1-year follow-up from a global study

Brain and Spine, 2021
Yann Philippe Charles, Aleksandr Krutko, Paulo Pereira, Carlos Santos, Yung Park, Vasileios Arzoglou, Seung-Won Park, Jörg Franke, Stephane Fuentes, Shisheng He, Tomá Hosszu, Pedro Varanda, Sergey Mlyavykh, Dimitri Vanhauwaert, Wolfgang Senker   +14 more
doaj   +1 more source

Gram‐Scale Synthesis of Hafnium‐Rich Carbon Dots for Preclinical Computed Tomography Imaging Across Various Systems

Advanced Science, EarlyView.
Hafnium (Hf)‐rich carbon dots (Hf‐rCDs) with high metal content (40.7%) and robust batch production capacity (>2 g per batch) are synthesized via a facile air‐assisted pyrolysis method. In vivo CT imaging demonstrates outstanding performance of Hf‐rCDs across multiple physiological systems and enables high‐resolution visualization of swine cervical ...
Shuo Li, Hengrui Wu, Jianqi Deng, Qiyu Sun, Yuping Zhang, Cai Zhang, Jinbin Pan, Dingbin Liu, Xuejun Zhang, Quan Zou, Xiaoyuan Chen, Shao‐Kai Sun   +11 more
wiley   +1 more source

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, EarlyView.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source