Results 161 to 170 of about 349,637 (309)

Can lumbopelvic parameters be used to predict thoracic kyphosis?

Brain and Spine, 2021
Yann Philippe Charles, Federico Solla, Sébastien Pesenti, Benjamin Blondel, Solène Prost, Georges Abi Lahoud, Jonathan Lebhar, Vincent Challier, Erik André Sauleau, Brice Ilharreborde   +9 more
doaj   +1 more source

Orthobiologics in spine surgery: a narrative review. [PDF]

J Spine Surg
Bonsu JM, Pisharody VA, Boden SD, Goh BC.   +3 more
europepmc   +1 more source

Mechanical Strain‐Programmed SDC1+ Sheath Fibroblasts Trigger CXCR4hi Neutrophil‐Mediated Enthesitis in Ankylosing Spondylitis

Advanced Science, EarlyView.
In ankylosing spondylitis (AS), mechanical strain‐programmed SDC1+ sheath fibroblasts secrete CXCL5 to recruit neutrophils and promote the activation of CXCR4hi neutrophils, thereby exacerbating enthesitis by promoting neutrophil extracellular traps (NETs) formation. SOX5 controls the generation of SDC1+ sheath fibroblasts via super‐enhancers.
Jiajie Lin, Zepeng Su, Yipeng Zeng, Yi Zhou, Chenying Zeng, Weihao Zhang, Qibo Li, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Guan Zheng, Wenhui Yu, Zhongyu Xie   +13 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Indolepropionic Acid Attenuates CFA-Induced Inflammatory Pain in Mice

Journal of Pain Research
Rui-Feng Ao,1 Heng-Rui Yong,1 Ying-Tao Hu,1 Yu-Sheng Huang,1 Jia-Wen Gao,1 Chen Tu,1,2 Jing-Shen Zhuang,1 Zhao-Ming Zhong1 1Division of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic
Ao RF, Yong HR, Hu YT, Huang YS, Gao JW, Tu C, Zhuang JS, Zhong ZM   +7 more
doaj  

Opioid Use in Opioid Naive Patients After Minimally Invasive Spine Surgery. [PDF]

Global Spine J
Moran D, Zakko P, Policht J, Roderick K, Park D.   +4 more
europepmc   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

Cervical sagittal alignment parameters across ages

Brain and Spine, 2021
Yann Philippe Charles, Sébastien Pesenti, Benjamin Blondel, Jean-Charles Le Huec, Vincent Fière, Louis Boissière, Vincent Challier, Aymeric Faure, Erik André Sauleau, Brice Ilharreborde   +9 more
doaj   +1 more source

Do spine surgery patients research their surgeon ahead of outpatient visits? [PDF]

J Spine Surg
Upadhyay D, Bice M, Williams S, Tribus C, Bernatz J.   +4 more
europepmc   +1 more source