Results 21 to 30 of about 77,711 (269)

Blocking VEGF by Bevacizumab Compromises Electrophysiological and Morphological Properties of Hippocampal Neurons

Frontiers in Cellular Neuroscience, 2019
A hallmark of glioblastoma multiforme (GBM) is neoangiogenesis, mediated by the overexpression of vascular endothelial growth factor (VEGF). Anti-VEGF antibodies, like bevacizumab, prolong progression-free survival in GBM, however, this treatment has ...
Pauline Latzer, Pauline Latzer, Olena Shchyglo, Tim Hartl, Tim Hartl, Veronika Matschke, Uwe Schlegel, Denise Manahan-Vaughan, Carsten Theiss   +8 more
doaj   +1 more source

Does High Protein Diets Effects on the Cornu Ammonis 1 Neurons in Male Rats? [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: The region of Cornu Ammonis 1 (CA1) in hippocampus has an obvious role in alteration of short-term memory to long-term. Proteins, as a crucial aspect of the cells, are involved in the structure and function of hippocampus. Aim: To study the
Shiva Roshankhah, Amir Abdolmaleki, Cyrus Jalili, Mohammad Reza Salahshoor   +3 more
doaj   +1 more source

Are Cactus Spines Modified Leaves? Morphological and Anatomical Characterization of Saguaro Seedlings (Carnegiea gigantea) with Special Focus on Aerial Organ Primordia

Plants
The reduction of leaves was a key event in the evolution of the succulent syndrome in Cactaceae, evolving from large, photosynthetic leaves in Pereskia to nearly suppressed microscopic foliar buds in succulent Cactoideae.
Cristina Betzabeth Miravel-Gabriel, Ryan Koeth, Nayelli Marsch-Martínez, Tania Hernández-Hernández   +3 more
doaj   +1 more source

Morphological Insights into Echinometra lucunter Spines Reveal Cellular Sources of Bioactive Molecules

Oceans
Echinometra lucunter, the most abundant sea urchin in Brazil, causes numerous accidents by puncture wounds, primarily on hands and feet. Beyond mechanical trauma, recent research has identified bioactive molecules in spine extracts and coelomic fluid ...
Juliana Mozer Sciani, Marta Maria Antoniazzi, Carlos Jared, José Roberto Machado Cunha da Silva, Daniel Carvalho Pimenta   +4 more
doaj   +1 more source

Combined DiI and Antibody Labeling Reveals Complex Dysgenesis of Hippocampal Dendritic Spines in a Mouse Model of Fragile X Syndrome

Biomedicines, 2022
Structural, functional, and molecular alterations in excitatory spines are a common hallmark of many neurodevelopmental disorders including intellectual disability and autism.
Luisa Speranza, Kardelen Dalım Filiz, Sarah Goebel, Carla Perrone-Capano, Salvatore Pulcrano, Floriana Volpicelli, Anna Francesconi   +6 more
doaj   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Spine and dine: A key defensive trait promotes ecological success in spiny ants

Ecology and Evolution, 2020
A key focus of ecologists is explaining the origin and maintenance of morphological diversity and its association with ecological success. We investigate potential benefits and costs of a common and varied morphological trait, cuticular spines, for ...
Benjamin D. Blanchard, Akihiro Nakamura, Min Cao, Stephanie T. Chen, Corrie S. Moreau   +4 more
doaj   +1 more source

Bone Mineral Density After Contemporary Treatment for Acute Lymphoblastic Leukaemia: A Matched Cross‐Sectional Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Reduced bone mineral density (BMD) has been reported in survivors of childhood and young adult acute lymphoblastic leukaemia (ALL); however, data from cohorts treated with contemporary protocols and including matched controls remain limited.
Karen Schow Jensen, Mette Tiedemann Skipper, Niels Holtum Birkebæk, Kjeld Schmiegelow, Thomas Leth Frandsen, Bente Langdahl, Rikke Beck Jensen, Asger Roer Pedersen, Christian Mølgaard, Liv Andrés‐Jensen, Birgitte Klug Albertsen   +10 more
wiley   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Lorlatinib‐Containing Therapy for MYCN‐Amplified, ALK‐Mutated Neuroblastoma With Bulky Leptomeningeal Relapse: A Case Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Central nervous system (CNS) relapse of neuroblastoma carries a poor prognosis, and craniospinal irradiation (CSI) poses substantial long‐term toxicity in young children. We report a toddler with MYCN‐amplified neuroblastoma harboring somatic ALK R1275Q who developed extensive leptomeningeal relapse with paraplegia.
Jinwoo Kim, Minji Kim, Nani Jung, Sung Eun Kim, Ji Yoon Kim, Mi Ae Chu, Jung Eun Kwon, Yeo Hyang Kim, So Mi Lee, Ki‐Su Park, Jeong Eun Lee, Ye Jee Shim   +11 more
wiley   +1 more source