Results 161 to 170 of about 4,488 (204)

De novo generation of dual-target compounds using artificial intelligence. [PDF]

iScience
Yasuda K, Berenger F, Amaike K, Ueda A, Nakagomi T, Hamasaki G, Li C, Otani NY, Kaitoh K, Tsuda K, Itami K, Yamanishi Y.   +11 more
europepmc   +1 more source

Evidence of COMT dysfunction in the olfactory bulb in Parkinson's disease. [PDF]

Acta Neuropathol
Beauchamp LC, Ellett LJ, Juan SMA, Liu XM, Hunt CPJ, Parish CL, Jacobson LH, Shepherd CE, Halliday GM, Bush AI, Vella LJ, Finkelstein DI, Barnham KJ.   +12 more
europepmc   +1 more source

Dual roles of dopaminergic pathways in olfactory learning and memory in the oriental fruit fly, Bactrocera dorsalis. [PDF]

Pestic Biochem Physiol
Yu J, Chen H, He J, Zeng X, Lei H, Liu J.   +5 more
europepmc   +1 more source

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Taurine interferes with spiperone binding in the striatum

Neuroscience, 1986
The effects of taurine and its structural analogues and two new anticonvulsant derivatives, taltrimide and MY-103, on the function of brain dopaminergic systems were studied by assessing their interference with the binding of [3H]spiperone to synaptic membranes isolated from rat striata. Two populations of binding sites were detected.
S. S. Oja, Pirjo Kontro
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Methodology of 3H-spiperone binding to lymphocytes

Journal of Psychiatric Research, 1990
Alterations in lymphocyte binding capacity for the dopamine antagonist 3H-spiperone may be of great interest in psychiatric and neurological disorders: an increase in capacity noted in lymphocytes of schizophrenic patients and their families may well turn out to be a phenotypic vulnerability marker. Since the 3H-spiperone binding assay with lymphocytes
Manfred Ackenheil, Brigitta Bondy, Rolf R. Engel   +2 more
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Uptake of 3H-spiperone by lymphocytes in schizophrenia

Journal of Psychiatric Research, 1989
Uptake of 3H-spiperone into lymphocytes obtained from control subjects (N = 22), chronic schizophrenics (N = 20), relatives with psychiatric disorder (N = 11) and unaffected relatives (N = 17) was studied. No differences were observed in spiperone uptake among any of the groups examined.
Bernard Lerer, Shimshon Itzchaky, Richard P. Ebstein   +2 more
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Spiperone: Tritium labelling at high specific activity

Applied Radiation and Isotopes, 2019
An efficient method is described to tritiate spiperone at high specific activity.
Crist N. Filer, Emma J. Shelton, Anne G. Laseter   +2 more
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Effect of Chronic Sulpiride on Striatal Spiperone Binding

International Pharmacopsychiatry, 1980
Increased 3H-spiperone binding after chronic neuroleptic treatment has been proposed as a molecular model of tardive dyskinesia. Sulpiride has been claimed to be an atypical neuroleptic that might not produce tardive dyskinesia. The effect of chronic sulpiride was, therefore, compared to that of chronic haloperidol on striatal 3H-spiperone binding.
Richard P. Ebstein, Samuel Gillis, Robert H. Belmaker, Jacob Bannet   +3 more
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A study of the kinetics of the interaction of spiperone with binding sites on human mononuclear cells: existence of a heterogeneous population of spiperone binding sites

Journal of Neuroimmunology, 1992
The kinetics and equilibrium of the interaction of [3H]spiperone with binding sites on human mononuclear cells were studied using a competitive displacement of spiperone by ketanserin, sulpiride, haloperidol, (+)- and (-)-butaclamol. [3H]Spiperone binding sites on human mononuclear cells were shown to be not of the D2, but most probably of the 5-HT2 ...
Sergei Zaitsev, Aleksei A. Koshkin, Sergei D. Varfolomeev, Irina I. Izumrudova   +3 more
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Biochemical Properties of Spiperone Binding to Rat Brain Membranes

Pharmacology, 1980
The biochemical properties of H-spiperone binding in vitro were studied systematically using a crude membrane homogenate of rat corpus striatum and separation by filtration. Scatchard analysis revealed a single high affinity site with a KD of 0.14 nM and Bmax of 26 fmol/mg of tissue. The dissociation constant obtained by measurements at equilibrium was
Frederick Wooten, Richard H. Sundermann
openaire   +3 more sources