Effect of hematopoietic stem cell on tumor necrosis factor- α expression, spiral artery remodeling and placental apoptosis in lead-exposed pregnant mice [PDF]
Asian Pacific Journal of Reproduction, 2017 Objective: To evaluate the effectiveness of hematopoietic stem cell (HSC) on TNF-α expression, spiral artery remodeling, and placental apoptosis.Methods: The study used pregnant mice divided to five groups of treatment: Group 1, without treatment; Group ...
Widjiati +4 more
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Porphyromonas gingivalis-mediated disruption in spiral artery remodeling is associated with altered uterine NK cell populations and dysregulated IL-18 and Htra1 [PDF]
Scientific Reports, 2022 Impaired spiral artery remodeling (IRSA) underpins the great obstetrical syndromes. We previously demonstrated that intrauterine infection with the periodontal pathogen, Porphyromonas gingivalis, induces IRSA in rats.
Tanvi Tavarna +3 more
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Role of microRNAs in trophoblast invasion and spiral artery remodeling: Implications for preeclampsia [PDF]
Frontiers in Cell and Developmental Biology, 2022 It is now well-established that microRNAs (miRNAs) are important regulators of gene expression. The role of miRNAs in placental development and trophoblast function is constantly expanding. Trophoblast invasion and their ability to remodel uterine spiral
Heyam Hayder +5 more
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Hyperglycemia disturbs trophoblast functions and subsequently leads to failure of uterine spiral artery remodeling [PDF]
Frontiers in Endocrinology, 2023 Uterine spiral artery remodeling is necessary for fetal growth and development as well as pregnancy outcomes. During remodeling, trophoblasts invade the arteries, replace the endothelium and disrupt the vascular smooth muscle, and are strictly regulated ...
Yueyue Zhu +4 more
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Uterine spiral artery remodeling involves endothelial apoptosis induced by extravillous trophoblasts through Fas/FasL interactions. [PDF]
, 2005 Objective— Invasion of uterine spiral arteries by extravillous trophoblasts in the first trimester of pregnancy results in loss of endothelial and musculoelastic layers.
Ashton, SV +6 more
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Decidual Vasculopathy in Preeclampsia and Spiral Artery Remodeling Revisited: Shallow Invasion versus Failure of Involution [PDF]
American Journal of Perinatology Reports, 2018 Decidual vasculopathy is commonly associated with preeclampsia and develops in the late pregnancy in the uterine spiral arteries, which were previously remodeled by the extravillous trophoblasts.
Peilin Zhang
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Role of GRK2 in Trophoblast Necroptosis and Spiral Artery Remodeling: Implications for Preeclampsia Pathogenesis [PDF]
Frontiers in Cell and Developmental Biology, 2021 Impaired invasion of extravillous trophoblasts and severe oxidative stress manifest the poor placentation in preeclampsia, which is life-threatening and more than a hypertensive disease of pregnancy.
Zi Lv +21 more
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Adaptive mechanisms controlling uterine spiral artery remodeling during the establishment of pregnancy [PDF]
, 2014 Implantation of the embryo into the uterus triggers the initiation of hemochorial placentation. The hemochorial placenta facilitates the acquisition of maternal resources required for embryo/fetal growth.
Chakraborty, Damayanti +4 more
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Leukemia Inhibitory Factor (LIF) Inhibition during Mid-Gestation Impairs Trophoblast Invasion and Spiral Artery Remodelling during Pregnancy in Mice. [PDF]
PLoS ONE, 2015 The placenta forms the interface between the maternal and fetal circulation and is critical for the establishment of a healthy pregnancy. Trophoblast cell proliferation, migration and invasion into the endometrium are fundamental events in the initiation
Amy Winship +4 more
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Hyperglycemia results in significant pathophysiological changes of placental spiral artery remodeling and angiogenesis, further contributing to congenital defects [PDF]
Frontiers in Bioscience-Landmark, 2021 Introduction: Hyperglycemic conditions achieved during pregnancy have been shown to have detrimental effects to fetal development and increase the prevalence of childhood comorbidities.
Yushu Qin +6 more
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