Role of GRK2 in Trophoblast Necroptosis and Spiral Artery Remodeling: Implications for Preeclampsia Pathogenesis [PDF]
Frontiers in Cell and Developmental Biology, 2021 Impaired invasion of extravillous trophoblasts and severe oxidative stress manifest the poor placentation in preeclampsia, which is life-threatening and more than a hypertensive disease of pregnancy.
Zi Lv +21 more
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VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development [PDF]
eLife, 2022 During formation of the mammalian placenta, trophoblasts invade the maternal decidua and remodel spiral arteries to bring maternal blood into the placenta.
Derek C Sung +13 more
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Porphyromonas gingivalis-mediated disruption in spiral artery remodeling is associated with altered uterine NK cell populations and dysregulated IL-18 and Htra1 [PDF]
Scientific Reports, 2022 Impaired spiral artery remodeling (IRSA) underpins the great obstetrical syndromes. We previously demonstrated that intrauterine infection with the periodontal pathogen, Porphyromonas gingivalis, induces IRSA in rats.
Tanvi Tavarna +3 more
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Role of microRNAs in trophoblast invasion and spiral artery remodeling: Implications for preeclampsia [PDF]
Frontiers in Cell and Developmental Biology, 2022 It is now well-established that microRNAs (miRNAs) are important regulators of gene expression. The role of miRNAs in placental development and trophoblast function is constantly expanding. Trophoblast invasion and their ability to remodel uterine spiral
Heyam Hayder +5 more
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Estrogen Actions in Placental Vascular Morphogenesis and Spiral Artery Remodeling: A Comparative View between Humans and Mice [PDF]
Cells, 2023 Estrogens, mainly 17β-estradiol (E2), play a critical role in reproductive organogenesis, ovulation, and fertility via estrogen receptors. E2 is also a well-known regulator of utero-placental vascular development and blood-flow dynamics throughout ...
Mariam Rusidzé +8 more
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Decidual Vasculopathy in Preeclampsia and Spiral Artery Remodeling Revisited: Shallow Invasion versus Failure of Involution [PDF]
American Journal of Perinatology Reports, 2018 Decidual vasculopathy is commonly associated with preeclampsia and develops in the late pregnancy in the uterine spiral arteries, which were previously remodeled by the extravillous trophoblasts.
Peilin Zhang
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Targeting A2M-LRP1 reverses uterine spiral artery remodeling disorder and alleviates the progression of preeclampsia [PDF]
Cell Communication and SignalingBackground Patients with early-onset preeclampsia (EOPE) have a most severe disease state. a2-macroglobulin (A2M) play a crucial role in the pathogenesis of EOPE, but its molecular basis and therapeutic potential remain unclear.
Zhengrui Huang +14 more
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Regulation of Uterine Spiral Artery Remodeling: a Review. [PDF]
Reprod Sci, 2020 AbstractExtravillous trophoblast remodeling of the uterine spiral arteries is essential for promoting blood flow to the placenta and fetal development, but little is known about the regulation of this process. A defect in spiral artery remodeling underpins adverse conditions of human pregnancy, notably early-onset preeclampsia and fetal growth ...
Albrecht ED, Pepe GJ.
europepmc +5 more sources
Hyperglycemia disturbs trophoblast functions and subsequently leads to failure of uterine spiral artery remodeling [PDF]
Frontiers in Endocrinology, 2023 Uterine spiral artery remodeling is necessary for fetal growth and development as well as pregnancy outcomes. During remodeling, trophoblasts invade the arteries, replace the endothelium and disrupt the vascular smooth muscle, and are strictly regulated ...
Yueyue Zhu +4 more
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Alpha-2-macroglobulin is involved in the occurrence of early-onset pre-eclampsia via its negative impact on uterine spiral artery remodeling and placental angiogenesis [PDF]
BMC Medicine, 2023 Background Pre-eclampsia (PE) is one of the leading causes of maternal and fetal morbidity/mortality during pregnancy, and alpha-2-macroglobulin (A2M) is associated with inflammatory signaling; however, the pathophysiological mechanism by which A2M is ...
Jingyun Wang +13 more
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