Results 21 to 30 of about 23,483 (241)

The role of extravillous trophoblasts and uterine NK cells in vascular remodeling during pregnancy

Frontiers in Immunology, 2022
Successful embryo implantation requires both a receptive endometrium and competent blastocysts. After implantation, the maternal decidua undergoes a series of changes, including uterine spiral artery (SA) remodeling to accommodate the fetus and provide ...
Xiao-Wei Wei, Xiao-Wei Wei, Xiao-Wei Wei, Xiao-Wei Wei, Yu-Chen Zhang, Fan Wu, Fu-Ju Tian, Fu-Ju Tian, Fu-Ju Tian, Fu-Ju Tian, Yi Lin   +10 more
doaj   +1 more source

The long noncoding RNA TARID regulates the CXCL3/ERK/MAPK pathway in trophoblasts and is associated with preeclampsia

Reproductive Biology and Endocrinology, 2022
Background The widely accepted explanation of preeclampsia (PE) pathogenesis is insufficient trophoblast invasion and impaired uterine spiral artery remodeling. However, the underlying molecular mechanism remains unclear.
Lingyun Liao, Min Liu, Yijie Gao, Xiaohong Wei, Yangxue Yin, Linbo Gao, Rong Zhou   +6 more
doaj   +1 more source

A multiscale model of vascular function in chronic thromboembolic pulmonary hypertension [PDF]

, 2021
Chronic thromboembolic pulmonary hypertension (CTEPH) is caused by recurrent or unresolved pulmonary thromboemboli, leading to perfusion defects and increased arterial wave reflections. CTEPH treatment aims to reduce pulmonary arterial pressure and reestablish adequate lung perfusion, yet patients with distal lesions are inoperable by standard surgical
arxiv   +1 more source

Alpha-2-macroglobulin is involved in the occurrence of early-onset pre-eclampsia via its negative impact on uterine spiral artery remodeling and placental angiogenesis

BMC Medicine, 2023
Background Pre-eclampsia (PE) is one of the leading causes of maternal and fetal morbidity/mortality during pregnancy, and alpha-2-macroglobulin (A2M) is associated with inflammatory signaling; however, the pathophysiological mechanism by which A2M is ...
Jingyun Wang, Ping Zhang, Mengyuan Liu, Zhengrui Huang, Xiaofeng Yang, Yuzhen Ding, Jia Liu, Xin Cheng, Shujie Xu, Meiyao He, Fengxiang Zhang, Guang Wang, Ruiman Li, Xuesong Yang   +13 more
doaj   +1 more source

Spiral artery blood flow during pregnancy: a systematic review and meta-analysis

BMC Pregnancy and Childbirth, 2020
Background Downstream remodeling of the spiral arteries (SpA) decreases utero-placental resistance drastically, allowing sustained and increased blood flow to the placenta under all circumstances.
Veronique Schiffer, Laura Evers, Sander de Haas, Chahinda Ghossein-Doha, Salwan Al-Nasiry, Marc Spaanderman   +5 more
doaj   +1 more source

Comparative Assessment of Biomechanical Parameters in Subjects With Multiple Cerebral Aneurysms Using Fluid--Structure Interaction Simulations [PDF]

ASME J. Biomech. Eng. 145(5) 051003 (2023), 2022
Cerebral aneurysm progression is a result of a complex interplay of the biomechanical and clinical risk factors that drive aneurysmal growth and rupture. Subjects with multiple aneurysms are unique cases wherein clinical risk factors are expected to affect each aneurysm equally, thus allowing for disentangling the effect of biomechanical factors on ...
arxiv   +1 more source

Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death. [PDF]

, 2007
Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss
Aplin, JD, Baker, PN, Cartwright, JE, Freeman, A, Harris, LK, Keogh, RJ, Whitley, GS   +6 more
core   +1 more source

Normalization of wall shear stress as a physiological mechanism for regulating maternal uterine artery expansive remodeling during pregnancy

FASEB BioAdvances, 2021
Outward remodeling of the maternal uterine circulation during pregnancy is essential for normal uteroplacental perfusion and pregnancy outcome. The physiological mechanism by which this process is regulated is unknown; we hypothesized that it involved ...
Eliyahu V. Khankin, Nga Ling Ko, Maurizio Mandalà, S. Ananth Karumanchi, George Osol   +4 more
doaj   +1 more source

Patient-specific Finite Element Modeling of Aneurysmal dilatation after chronic type B aortic dissection [PDF]

Computational Biomechanics for Medicine, Springer International Publishing, pp.15-38, 2022, 2023
Progressive aneurysmal dilatation is a well-recognized complication in patients with chronic type B aortic dissection (cTBAD), which may lead to a delayed rupture and create a life-threatening condition. However, our understanding of such aortic expansion in cTBAD remains weak.
arxiv   +1 more source

Effects of Circulating and Local Uteroplacental Angiotensin II in Rat Pregnancy. [PDF]

, 2010
The renin-angiotensin (Ang) system is important during placental development. Dysregulation of the renin-Ang system is important in preeclampsia (PE). Female rats transgenic for the human angiotensinogen gene crossed with males transgenic for the human ...
Brosnihan, KB, Cartwright, JE, Dechend, R, Geusens, N, Hering, L, Herse, F, Huppertz, B, Luft, FC, Muller, DN, Pijnenborg, R, Staff, AC, Verlohren, S, Wenzel, K   +12 more
core   +1 more source