Results 11 to 20 of about 12,432 (295)

Synthesis and Characterization of New Spiroheterocyclic from Isatin and Evaluation of Some Their Antifungal and Antibacterial Activity [PDF]

مجلة جامعة الانبار للعلوم الصرفة
Spiro compounds Spiro cycles are widely found in natural products, medicines, and functional materials[1] the spiro atom forces the planes of the two rings to almost face one another, spiro compounds are a desirable subclass of heterocyclic scaffolds. In
Zubaida Al-Heety, Ali Al-Nasseri
doaj   +1 more source

New 6′-Amino-5′-cyano-2-oxo-1,2-dihydro-1′H-spiro[indole-3,4′-pyridine]-3′-carboxamides: Synthesis, Reactions, Molecular Docking Studies and Biological Activity

Molecules, 2023
The purpose of this work was to prepare new isatin- and monothiomalondiamide-based indole derivatives, as well as to study the properties of the new compounds.
Victor V. Dotsenko, Nawras T. Jassim, Azamat Z. Temerdashev, Zainab R. Abdul-Hussein, Nicolai A. Aksenov, Inna V. Aksenova   +5 more
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Pyridinium chlorochromate chemistry. New insight into oxidation of tetrahydrofurans [PDF]

, 2017
A thorough investigation of the minor oxidation products of two penta-tetrahydrofuran compounds with pyridinium chlorochromate has been carried out. Isolation of ring-B oxygenated spiroketal and degradation products, including polycyclic mono- and bis ...
Borbone, Nicola, D'Errico, Stefano, Oliviero, Giorgia, Piccialli, Vincenzo, Zaccaria, Sabrina   +4 more
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Multicomponent synthesis, biological evaluation and molecular docking of new spiro-oxindole derivatives

Journal of Taibah University for Science, 2017
A new series of spiro-oxindoles that were identified based upon their ability to inhibit methionine tRNA synthase (PDB ID: 1PFV) and glucosamine-6-phosphate synthase (PDB ID: 1JXA) enzymes in virtual screening was synthesized by a three-component 1,3 ...
M. Sapnakumari, B. Narayana, K.S. Shashidhara, B.K. Sarojini   +3 more
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Competitive formation of spiro and ansa derivatives in the reactions of tetrafluorobutane-1,4-diol with hexachlorocyclotriphosphazene: a comparison with butane-1,4-diol [PDF]

, 2006
Reaction of hexachlorocyclotriphosphazene, N3P3Cl6 (1), in two stoichiometries (1:1.2 and 1:3) with the sodium derivative of the fluorinated diol, 2,2,3,3-tetrafluorobutane-1,4-diol, (2), in THF solution at room temperature afforded six products, whose ...
Beşli, S., Coles, Simon J., Davies, David B., Eaton, R.J., Kiliç, A., Shaw, Robert A.   +5 more
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Microwave Assisted Synthesis of Some New Heterocyclic Spiro-Derivatives with Potential Antimicrobial and Antioxidant Activity

Molecules, 2010
Homophthalic anhydride reacts with different aromatic amines to produce N-substituted homophthalimides. Bromination of the latter produces 4,4-dibromo-homophthalimide derivatives that can be used as precursors for spiro-derivatives.
Mohamed Mohamed Youssef, Mahmoud Ahmed Amin   +1 more
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Vanadium(V) tetra-phenolate complexes: synthesis, structural studies and ethylene homo-(co-)polymerization capability [PDF]

, 2015
Reaction of α,α,α′,α′-tetrakis(3,5-di-tert-butyl-2-hydroxyphenyl)-p-xylene (p-L¹H₄) with two equivalents of [VO(OR)₃] (R = nPr, tBu) in refluxing toluene afforded, after work-up, the complexes {[VO(OnPr)(THF)]₂ (μ-p-L¹)}·2(THF) (1·2(THF)) or {[VO(OtBu)]₂
Elsegood, Mark R. J., Michiue, K., Michiue, Kenji, Prior, Timothy J., Redshaw, Carl, Walton, Mark J.   +5 more
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C–H insertion as a key step to spiro-oxetanes, scaffolds for drug discovery [PDF]

, 2017
A new route to spiro-oxetanes, potential scaffolds for drug discovery, is described. The route is based on the selective 1,4-C–H insertion reactions of metallocarbenes, generated from simple carbonyl precursors in flow or batch mode, to give spiro-β ...
Besnard, Bull, Burkhard, Burkhard, Carreira, Chalyk, Colomer, Davies, Davies, Davis, Deadman, Doyle, Eun, Feng, Ford, Fu, Furuya, Gallou, Hansen, Ishiyama, Karawajczyk, Kraus, Litvinas, Lombard, Monleón, Murphy, Murray, Möller, Müller, Müller, Nadin, Nicolle, Nicolle, Nortcliffe, Nortcliffe, Pettit, Ritchie, Rogers-Evans, Scott, Ueda, Voth, Wamser, Wang, Wang, Wetzel, Wuitschik, Wuitschik, Wuitschik, Yato, Ye   +49 more
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Synthesis of Spiro Heterocyclic Compounds

E-Journal of Chemistry, 2010
Reaction of isatin with acetophenone derivatives gave 3-hydroxy-3-phenacyl oxindole derivatives (II), dehydration of (II) gave 3-phenacylidene-2-indolinone derivatives (III).
Mohamed N. Ibrahim, Mohamed F. El-Messmary, Mohamed G. A. Elarfi   +2 more
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Novel Rearrangements in the Reactions Directed Toward Preparation of Spiro-N,N-ketals: Reactions of Naphthalene-1,8-diamine with Ninhydrin and Isatin

Molecules, 2012
Spiro-N,N-ketal 5, consisting of a phthaloperine heterocyclic ring and a naphtha[1,8-ef][1,4]diazepine ring, was obtained along with spiro-N,N-ketal 2 via 2,2-condensation in the reaction of ninhydrin with naphthalene-1,8-diamine.
Keiji Kobayashi, Junko Kimura, Reiko Aoyama, Hideyuki Seto, Motoko Akita   +4 more
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