Spiro compounds - Open Access .click

Results 1 to 10 of about 10,792 (98)

Facile synthesis of hydantoin/1,2,4-oxadiazoline spiro-compounds via 1,3-dipolar cycloaddition of nitrile oxides to 5-iminohydantoins [PDF]

Beilstein Journal of Organic Chemistry
The cycloaddition of 1,3-dipoles at C=N bonds is a relatively rare process, in contrast to the widespread cycloaddition reactions at C=C, C≡C, and C=S bonds.
Juliana V. Petrova +6 more
doaj +2 more sources

Entry to new spiroheterocycles via tandem Rh(II)-catalyzed O–H insertion/base-promoted cyclization involving diazoarylidene succinimides

Beilstein Journal of Organic Chemistry
A facile approach to novel medicinally relevant spiro heterocyclic scaffolds (namely furan-2(5H)-ones, tetrahydrofurans and pyrans spiro-conjugated with the succinimide ring) has been developed.
Alexander Yanovich +4 more
doaj +1 more source

Microwave-Assisted Synthesis and Antimicrobial Evaluation of Novel Spiroisoquinoline and Spiropyrido[4,3-d]pyrimidine Derivatives

Molecules, 2015
Bromination of N-substituted homophthalimides and tetrahydropyrido[4,3-d]- pyrimidine-5,7-diones produces 4,4-dibromohomophthalimide and 8,8-dibromo-tetrahydropyrido[4,3-d]pyrimidine-5,7-dione derivatives, respectively, that can be used as precursors for
Rasha M. Faty, Mohamed S. Rashed, Mohamed M. Youssef +2 more
doaj +1 more source

An Unexpected Formation of Spiro Isoxazoline-Dihydrofurane Compounds from Substituted Ketofurfuryl Alcohols

Molecules
Oximation of substituted ketofurfuryl alcohols in the presence of hydroxylamine hydrochloride and pyridine in ethanol as solvent led to a new class of spiro derivatives presenting a 7-methylene-1,6-dioxa-2-azaspiro [4.4] nona-2,8-diene skeleton along ...
Claire Cuyamendous +2 more
doaj +1 more source

Photochemical Rearrangement of 8- methyl Spiro [2.5] oct-7-en-4-one to 4-methyl Spiro [2.5] oct-4-en-6-one [PDF]

Journal of Sciences, Islamic Republic of Iran, 1989
Irradiation of &methyl spiro [2.5] oct-7-en-4-one through its singlet excited state resulted in the formation of 4-methyl spirO [2.5] oct-4-en -6-one. We have used the cyclopropyl moiety in the molecule as a probe to study the operating mechanism in the
doaj

Synthesis, toxicological and in silico evaluation of novel spiro pyrimidines against Culex pipiens L. referring to chitinase enzyme

Scientific Reports
The exponential development of resistance to conventional chemical insecticides adds another important motive for the creation of novel insecticidal active agents.
Eslam M. Abbass +4 more
doaj +1 more source

Synthesis, Molecular Docking Study, Anti-Oxidant and Cytotoxicity Evaluation of New Spiro Six Membered Ring Derivatives of 5-nitro isatin

Iraqi Journal of Pharmaceutical Sciences
Spiro-5-nitro isatino six memberd ring (quinazoline-4-one, thiazine-4-one and oxazine-4-one) respectively were produced by a cycloaddition of 5-nitro isatin Schiff bases [1–5] with anthranilic acid, o-mercapto benzoic acid and salicylic acid.
Hala Ayad Mohamed Rasheed, Suaad M. H. Al-Majidi +1 more
doaj +1 more source

STUDIES ON SPIROHETEROCYCLES : SYNTHESIS OF NEW SPIRO 4- THIAZOLIDINONES AS POSSIBLE BIODYNAMICS [PDF]

Journal of Sciences, Islamic Republic of Iran, 1992
Spiro-4- thiazolidinones have been synthesized by the cyclocondensation of phthalazinyl hydrazones with cyclic ketones and substituted mercapto acetic acids. Compounds were screened for their antibacterial, antifungal and antihypertensive activity.
doaj

Syntheses and medicinal chemistry of spiro heterocyclic steroids

Beilstein Journal of Organic Chemistry
There is compelling evidence that incorporating a heterocyclic moiety into a steroid can alter its pharmacological and pharmacokinetic properties, driving intense interest in the synthesis of such hybrids among research groups. In this review, we present
Laura L. Romero-Hernández +5 more
doaj +1 more source

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