Green Synthesis of Spiro Compounds with Potential Anticancer Activity through Knoevenagel/Michael/Cyclization Multicomponent Domino Reactions Organocatalyzed by Ionic Liquid and Microwave-Assisted [PDF]
Molecules, 2022 In this work a microwave-assisted Knoevenagel/Michael/cyclization multicomponent domino methodology, using ethanol as solvent and the ionic liquid 1-methylimidazolium chloride as catalyst was developed for the synthesis of spiro compounds.
Regina Westphal +11 more
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Facile synthesis of hydantoin/1,2,4-oxadiazoline spiro-compounds via 1,3-dipolar cycloaddition of nitrile oxides to 5-iminohydantoins [PDF]
Beilstein Journal of Organic ChemistryThe cycloaddition of 1,3-dipoles at C=N bonds is a relatively rare process, in contrast to the widespread cycloaddition reactions at C=C, C≡C, and C=S bonds.
Juliana V. Petrova +6 more
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Highly congested spiro-compounds via photoredox-mediated dearomative annulation cascade. [PDF]
Commun Chem, 2022 Photo-mediated radical dearomatization involving 5- exo -trig cyclizations has proven to be an important route to accessing spirocyclic compounds, whereas 6- exo -trig spirocyclization has been much less explored.
Zhou C +4 more
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CXIX.—The formation and stability of spiro-compounds. Part I. spiro-Compounds from cyclohexane [PDF]
J. Chem. Soc., Trans., 1915 n ...
Beesley, Richard Moore +2 more
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Synthesis of Spiro Heterocyclic Compounds [PDF]
E-Journal of Chemistry, 2010 Reaction of isatin with acetophenone derivatives gave 3-hydroxy-3-phenacyl oxindole derivatives (II), dehydration of (II) gave 3-phenacylidene-2-indolinone derivatives (III).
Mohamed N. Ibrahim +2 more
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Spiro-compounds. Part I. A New Route to Spiro compounds. Synthesis of cycloHexane-spiro- cyclopentane [PDF]
, 1936 Spiro-compounds. Part I. A New Route to Spiro compounds.
NRIPENDRA NATH CHATTERJEE
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Stereoselective Domino Reactions in the Synthesis of Spiro Compounds
Synthesis, 2022 AbstractThis review summarizes the latest developments in asymmetric domino reactions, with the emphasis on the preparation of spiro compounds. Discussions on the stereoselectivity of the transformations, the reaction mechanisms, the rationalization of the stereochemical outcome, and the applications of domino reactions to the synthesis of biologically
Regina Westphal +4 more
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SPIRO-COMPOUNDS. PART V. THE FORMATION AND TRANSFORMATION OF SPIRO-COMPOUNDS FROM 3-AND 2-METHYLCYCLOHEXANONES. [PDF]
, 1938 Spiro-compounds have been built up from methylcyclohexanone to examine, on the basis of the valency deflexion hypothesis, the nature of strain in cyclohexane ring in which ortho or meta positions are occupied by groups. β-Methylnaphthalene has been obtained as a product of dehydrogenation of 3-methylcyclohexane-spiro-cyclopmtane-5'-carboxylic acid.
NRIPENDRA NATH CHATTERJEE +1 more
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New development in the enantioselective synthesis of spiro compounds [PDF]
Chemical Society Reviews, 2018 In this review we summarize the latest developments in the enantioselective synthesis of spirocompounds. The most important organometallic and organocatalytic methodologies are highlighted.
Hao Guo +5 more
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CHEMISTRY OF SPIRO-COMPOUNDS. PART II. SYNTHESIS OF CYCLOPENTANE-SPIRO-CYCLOPENTANONE. [PDF]
, 1939 cycloPentane—spiro-cyclopentanone has been synthesised from cyclopentane-I-carboxyI-butyric acid, which has been synthesised in a way which leaves no doubt regarding its configuration. The lactone obtained by the reduction of the anhydride of cyciopentane-I-carboxy-I-acetic acid yields a bromo-ester which by the action of sodiomalonic ester and ...
MUHAMMAD QUDRAT-I-KHUDA +1 more
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