Facile synthesis of hydantoin/1,2,4-oxadiazoline spiro-compounds via 1,3-dipolar cycloaddition of nitrile oxides to 5-iminohydantoins [PDF]
Beilstein Journal of Organic ChemistryThe cycloaddition of 1,3-dipoles at C=N bonds is a relatively rare process, in contrast to the widespread cycloaddition reactions at C=C, C≡C, and C=S bonds.
Juliana V. Petrova +6 more
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Chemistry Teacher Trainees’ use of Molecular Models in Learning Spiro and Bicyclic Compounds
Science Education International, 2022 The study diagnosed chemistry teacher trainees’ difficulties in naming and writing structures of spiro and bicyclic compounds. The case study design was conducted in a constructivist environment to enhance chemistry teacher trainees’ ability to construct,
Claudia Quayson +3 more
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Green Synthesis of Spiro Compounds with Potential Anticancer Activity through Knoevenagel/Michael/Cyclization Multicomponent Domino Reactions Organocatalyzed by Ionic Liquid and Microwave-Assisted [PDF]
Molecules, 2022 In this work a microwave-assisted Knoevenagel/Michael/cyclization multicomponent domino methodology, using ethanol as solvent and the ionic liquid 1-methylimidazolium chloride as catalyst was developed for the synthesis of spiro compounds.
Regina Westphal +11 more
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Synthesis of Spiro Heterocyclic Compounds [PDF]
E-Journal of Chemistry, 2010 Reaction of isatin with acetophenone derivatives gave 3-hydroxy-3-phenacyl oxindole derivatives (II), dehydration of (II) gave 3-phenacylidene-2-indolinone derivatives (III).
Mohamed N. Ibrahim +2 more
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Spiro heterocyclic compounds. V. Synthesis of spiro(homophthalimide-4,4'-(4'H-pyran)) compounds.
Chemical and Pharmaceutical Bulletin, 1982 The reaction of 2-methylphthalonimide (1) with malononitrile gave 4-dicyanomethylene-2-methylhomophthalimide (2) in 95% yield. The Michael reaction of 2 with compounds having an active methylene or methyl group (3a-d) afforded the corresponding spiro [2-methylhomophthalimide-4, 4'-(4'H-pyran)] compounds (4a-d). In contrast, the reaction of 2 with other
TERUHISA FUJIMAKI, Hirotaka Otomasu
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, 1936 Spiro-compounds. Part I. A New Route to Spiro compounds.
NRIPENDRA NATH CHATTERJEE
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When Poor Light‐Emitting Spiro Compounds in Solution Turn into Emissive Pure Layers in Organic Light‐Emitting Diodes: The Key Role of Phosphine Substituents [PDF]
Advanced Photonics Research, 2022 Spiro compounds are widely used as host matrices in organic light‐emitting diodes (OLEDs). Here, inspired by the recent developments in thermally activated delayed fluorescence (TADF) materials, the potential as a light emitter of two spiro‐configured ...
Pauline Tourneur +8 more
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Chemical and Pharmaceutical Bulletin, 1982 Nitrosation of 2-methylisoquinoline-1, 3 (2H, 4H)-dione (I) with NaNO2 in AcOH afforded the 4-nitroso compound (II) in almost quantitative yield. Catalytic reduction of II produced 4-imino-2-methylisoquinoline-1, 3 (2H, 4H)-dione (III) and a small amount of 4, 4'-bi-2-methylisoquinoline-1, 3 (2H, 4H)-dione (IV).
SACHIYO TAHARA +2 more
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CHEMISTRY OF SPIRO-COMPOUNDS. PART II. SYNTHESIS OF CYCLOPENTANE-SPIRO-CYCLOPENTANONE.
, 1939 cycloPentane—spiro-cyclopentanone has been synthesised from cyclopentane-I-carboxyI-butyric acid, which has been synthesised in a way which leaves no doubt regarding its configuration. The lactone obtained by the reduction of the anhydride of cyciopentane-I-carboxy-I-acetic acid yields a bromo-ester which by the action of sodiomalonic ester and ...
MUHAMMAD QUDRAT-I-KHUDA +1 more
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Spiro(isobenzofuranazetidine) Compounds for Treating Autoimmune Diseases [PDF]
ACS Medicinal Chemistry Letters, 2021 Ram W. Sabnis
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