Results 21 to 30 of about 10,792 (98)

Multicomponent synthesis, biological evaluation and molecular docking of new spiro-oxindole derivatives

Journal of Taibah University for Science, 2017
A new series of spiro-oxindoles that were identified based upon their ability to inhibit methionine tRNA synthase (PDB ID: 1PFV) and glucosamine-6-phosphate synthase (PDB ID: 1JXA) enzymes in virtual screening was synthesized by a three-component 1,3 ...
M. Sapnakumari, B. Narayana, K.S. Shashidhara, B.K. Sarojini   +3 more
doaj   +1 more source

Microwave Assisted Synthesis of Some New Heterocyclic Spiro-Derivatives with Potential Antimicrobial and Antioxidant Activity

Molecules, 2010
Homophthalic anhydride reacts with different aromatic amines to produce N-substituted homophthalimides. Bromination of the latter produces 4,4-dibromo-homophthalimide derivatives that can be used as precursors for spiro-derivatives.
Mohamed Mohamed Youssef, Mahmoud Ahmed Amin   +1 more
doaj   +1 more source

Novel Rearrangements in the Reactions Directed Toward Preparation of Spiro-N,N-ketals: Reactions of Naphthalene-1,8-diamine with Ninhydrin and Isatin

Molecules, 2012
Spiro-N,N-ketal 5, consisting of a phthaloperine heterocyclic ring and a naphtha[1,8-ef][1,4]diazepine ring, was obtained along with spiro-N,N-ketal 2 via 2,2-condensation in the reaction of ninhydrin with naphthalene-1,8-diamine.
Keiji Kobayashi, Junko Kimura, Reiko Aoyama, Hideyuki Seto, Motoko Akita   +4 more
doaj   +1 more source

Synthesis of Spiro Heterocyclic Compounds

E-Journal of Chemistry, 2010
Reaction of isatin with acetophenone derivatives gave 3-hydroxy-3-phenacyl oxindole derivatives (II), dehydration of (II) gave 3-phenacylidene-2-indolinone derivatives (III).
Mohamed N. Ibrahim, Mohamed F. El-Messmary, Mohamed G. A. Elarfi   +2 more
doaj   +1 more source

The tert-Amino Effect in Heterocyclic Chemistry. Synthesis of Spiro Heterocycles

Molecules, 2005
The tert-amino reaction effect was examined. A new method to synthesize spiro heterocycles is presented. It was shown that the “tert-amino effect” could be applied to the formation of spiro-fused heterocycles.
Y. Morzherin, O. Eltsov, L. Dyudya, T. Glukhareva, E. D’yachenko   +4 more
doaj   +1 more source

Synthesis and evaluation of the antioxidant activity of new spiro-1,2,4-triazine derivatives applying Ag/Fe3O4/CdO@MWCNT MNCs as efficient organometallic nanocatalysts

Frontiers in Chemistry, 2022
We applied the Petasites hybridus rhizome water extract as green media so that Ag/Fe3O4/CdO@ multi-walled carbon nanotubes magnetic nanocomposites (Ag/Fe3O4/CdO@MWCNTs MNCs) could be prepared.
Elham Ezzatzadeh, Somayeh Soleimani-Amiri, Zinatossadat Hossaini, Khatereh Khandan Barani   +3 more
doaj   +1 more source

Simple approach to thieno[3,2-d]pyrimidines as new scaffolds of antimicrobial activities

Acta Pharmaceutica, 2016
6ʹ-(4-Chlorophenyl)-spiro[cyclohexane-1,2ʹ-thieno[3,2-d][1,3] oxazin]-4ʹ(1ʹH)-one (1) was synthesized and used as a starting material for the synthesis of a novel series of spiro compounds having biologically active sulfonamide 2a-e and 3ʹ-(4 ...
Hafez Hend N., El-Gazzar Abdel-Rhman B. A., Zaki Magdi E. A.   +2 more
doaj   +1 more source

Desing, synthesis and anti-inflammatory activity of dirivatives 10-R-3-aryl-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones of spiro-fused cyclic frameworks

Acta Chimica Slovenica, 2017
Present work is devoted to the purposeful search of novel promising anti-inflammatory agents among the insufficiently known 3'-R-10'-R1-spiro[hetaryl-3(4),6'-[1,2,4]triazino[2,3-c]quinazolin]-2'(7'H)-ones.
Oleksandra Kolomoets, Oleksii Voskoboynik, Oleksii Antypenko, Galyna Berest, Inna Nosulenko, Vitaliy Palchikov, Olexandr Karpenko, Sergiy Kovalenko   +7 more
doaj   +1 more source

Microbial Transformation of neo-Clerodane Diterpenoid, Scutebarbatine F, by Streptomyces sp. CPCC 205437

Frontiers in Microbiology, 2021
Biotransformation of the neo-clerodane diterpene, scutebarbatine F (1), by Streptomyces sp. CPCC 205437 was investigated for the first time, which led to the isolation of nine new metabolites, scutebarbatine F1–F9 (2–10). Their structures were determined
Dewu Zhang, Xiaoyu Tao, Guowei Gu, Yujia Wang, Wenxia Zhao, Wuli Zhao, Yan Ren, Shengjun Dai, Liyan Yu   +8 more
doaj   +1 more source

Synthesis of spiro quasi[1]catenanes and quasi[1]rotaxanes via a templated backfolding strategy

Nature Communications, 2017
Spiro compounds contain two or more rings linked together through one common atom. Here the authors provide a method to backfold both rings, producing spiro quasi[1]catenanes, via a strategy of temporarily linking the linear intermediates with covalent ...
Luuk Steemers, Martin J. Wanner, Martin Lutz, Henk Hiemstra, Jan H. van Maarseveen   +4 more
doaj   +1 more source