RAD51 and RAD51 paralog inhibition sensitizes nonreplicating quiescent keratinocytes to UV radiation
UV radiation and other compounds generate DNA adducts that block transcription and induce cell death if not removed by the nucleotide excision repair system. In this work, we used a small‐scale pharmacological screen to discover that inhibition of the recombinase RAD51 sensitized nonreplicating quiescent keratinocytes to both UVR and other agents that ...
Saman Khan +3 more
wiley +1 more source
Spotlight July–September 2026: What's New in JEADV—Editor‐in‐Chief's Selection
JEADV Clinical Practice, Volume 5, Issue 3, Page 763-768, September 2026.
Carle Paul
wiley +1 more source
Patterns of spironolactone management following hyperkalemia among hospitalized patients with heart failure and reduced ejection fraction: a retrospective single-center study. [PDF]
Alshammari AS +14 more
europepmc +1 more source
Spironolactone versus Bicalutamide for Female Pattern Hair Loss: A 24-Month Unicenter Retrospective Comparative Study of Effectiveness and Safety. [PDF]
Gil-Redondo R +9 more
europepmc +1 more source
PRO/CON debate: nonsteroidal versus steroidal mineralocorticoid receptor antagonists in chronic kidney disease: progress, pragmatism, and remaining uncertainties. [PDF]
Agarwal R, Vogt L, Floege J, Zoccali C.
europepmc +1 more source
Spironolactone therapy in older patients - The impact of renal dysfunction
Low dose spironolactone reduces the risk of death from heart failure. We examined the effects of spironolactone on potassium homeostasis in a cohort of elderly patients with congestive heart failure (CHF). Eighteen patients >70 years, mean 80.5 (+/- SD 6.
Mulkerrin, E., McAvoy, H.
core
Sex-Specific Safety Signals of Finerenone Versus Spironolactone: Insights From the FDA Adverse Event Reporting System. [PDF]
Singla A +9 more
europepmc +1 more source
Upregulated Renal Mineralocorticoid Receptor and 11β-Hydroxysteroid Dehydrogenase Type 2 Are Associated with K<sup>+</sup> Retention During MR Antagonism in Female Spontaneously Hypertensive Rats. [PDF]
Baranovskaya I +8 more
europepmc +1 more source
Risk of Hyperkalemia in Patients with Heart Failure Treated with Spironolactone in Combination with Sacubitril/Valsartan vs. Renin-Angiotensin System Inhibitors. [PDF]
Crum KL, Vaduganathan M, Desai RJ.
europepmc +1 more source
Finerenone Alleviates Cardiac Microvascular Injury and Neutrophil Extracellular Traps Formation in Diabetic Cardiomyopathy via Regulating AKT1 Phosphorylation. [PDF]
Li S +12 more
europepmc +1 more source

