Results 131 to 140 of about 33,667 (245)

Liver cirrhosis is associated with altered glucocorticoid metabolism related to disease severity

Journal of Internal Medicine, Volume 300, Issue 4, Page 513-527, October 2026.
Abstract Background Liver cirrhosis (LC) is frequently complicated by adrenal dysfunction; however, whether cirrhosis drives the coordinated, pathway‐specific reprogramming of cortisol metabolism remains unclear. Objectives We aimed to characterize axis‐specific alterations in cortisol metabolism in patients with LC, those with adrenal insufficiency ...
Soyeon Park, Min Jeong Park, Hye Won Yang, Jeayeon Park, Su Jong Yu, Seung Shin Park, Man‐Ho Choi, Eun Ju Cho, Jung Hee Kim   +8 more
wiley   +1 more source

Effects of Spironolactone on Proteinuria of Patients with Type 2 Diabetes

مجله دانشکده پزشکی اصفهان, 2012
Background: Diabetic nephropathy is the most common cause of kidney failure. We investigated the beneficial effects of spironolactone, alone and in combination with hydrochlorothiazide, on diabetic nephropathy.
Mohamad Karami Horestani, Saeed Behradmanesh, Ali Momeni, Azar Baradaran   +3 more
doaj  

Elucidating the Molecular Mechanisms of Vitex negundo L. in Polycystic Ovary Syndrome via Metabolomics‐Driven Network Pharmacology

Biomedical Chromatography, Volume 40, Issue 9, September 2026.
ABSTRACT Polycystic ovary syndrome (PCOS) is a hormonal disorder marked by irregular menstrual cycles, elevated androgen levels, ovarian cysts, hirsutism, acne and other symptoms. While conventional medications such as Metformin and Spironolactone are commonly prescribed, they are often associated with undesirable side effects.
Nishmitha R. Poojary, Neeharika Narisepalli Venkatasai, Kannath U. Sanjay, Supraja M. Kodanch, Padmalatha S. Rai   +4 more
wiley   +1 more source

A Spironolactone−Saccharin 1:1 Cocrystal Hemihydrate

, 2016
We investigated the structures of the hydrated and dehydrated states and the in vitro dissolution of a spironolactone−saccharin 1:1 cocrystal hemihydrate, the cocrystal hydrate of a nonionizable, poorly water-soluble drug with a pharmaceutically ...
Hidehiro Uekusa (1441441), Ryusuke Takano (2261857), Yoshiki Hayashi (840865), Noriyuki Takata (2131315), Katsuhide Terada (2016769)   +4 more
core   +1 more source

Chronic Kidney Disease in Children Within Five Years After Ifosfamide Chemotherapy for Childhood Cancer: A Dutch Pediatric Oncology Cohort Study

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Introduction Children treated with ifosfamide seem to have an increased risk for developing chronic kidney disease (CKD) already within the first years following chemotherapy. However, studies investigating CKD prevalence in this specific phase are scarce.
Lotte Pitlo, Francis S. P. L. Wens, Paulien A. M. A. Raymakers‐Janssen, Lianne M. Haveman, Johannes H. M. Merks, Martine van Grotel, Geert O. Janssens, Marta Fiocco, Marry M. van den Heuvel‐Eibrink, Gerrit van den Berg   +9 more
wiley   +1 more source

The effect of low-dose spironolactone on resistant hypertension

, 2010
Our objective was to estimate the effect of addition of low-dose spironolactone to previous antihypertensive therapy in patients with resistant hypertension.
Jesper Hallas, Ib A. Jacobsen, Engbaek, Mette, Jacobsen, Ib A, Hjerrild, Mette, Hallas, Jesper, Mette Engbaek, Mette Hjerrild   +7 more
core   +1 more source

The Aldosterone Blockade for Health Improvement Evaluation in End-Stage Renal Disease (ACHIEVE) Trial: Rationale and Clinical Research Protocol

Canadian Journal of Kidney Health and Disease
Background: The mineralocorticoid aldosterone may contribute to the risk of cardiovascular morbidity and mortality in patients receiving maintenance dialysis. Whether spironolactone, a mineralocorticoid receptor antagonist, improves outcomes for patients
Michael Walsh, David Collister, Martin Gallagher, Patrick B. Mark, Janak R. de Zoysa, Jessica Tyrwhitt, Karthik Tennankore, Laura Sola, Gilmar Reis, Denis Xavier, Russell Villanueva, Wen J. Liu, Camilo Félix, Li Zuo, Mustafa Arici, Vivekanand Jha, Ron Wald, Amanda Y. Wang, Atiya R. Faruqui, Fei Yuan, Shun Fu Lee, Alena Kuptsova, Courtney Christou, P. J. Devereaux,   +24 more
doaj   +1 more source

Overview of Photochemical Reactions for the Synthesis of Aza and Oxa‐Spirocyclic Compounds Under Visible Light Irradiation

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This review presents the visible‐light‐mediated photochemical reaction for the synthesis of aza, oxa, and aza–oxa spirocyclic compounds via photoinduced electron transfer (PET), hydrogen atom transfer (HAT), single‐electron transfer (SET), or energy transfer (EnT) pathways.
Annu Bhardwaj, Shivangi Jaiswal, Khushboo Bhardwaj, Swapnil Sharma, Jaya Dwivedi   +4 more
wiley   +1 more source

A comparison of the aldosterone-blocking agents eplerenone and spironolactone

, 2008
Improved understand in g of the adverse pharmacological properties of aldosterone has prompted investigation of the clinical benefits of blocking aldosterone at the receptor level.
Krum, Henry, Williams, Gordon H., Struthers, Allan   +2 more
core   +1 more source

Efficacy of different topical spironolactone treatments for acne vulgaris: A meta-analysis

Pakistan Journal of Pharmaceutical Sciences
Background: Topical spironolactone could serve as an alternative to oral therapy for acne vulgaris, but its efficacy requires further validation. Objectives: This study aimed to evaluate the efficacy of topical spironolactone monotherapy for acne ...
Wenyu Huang, Chao Tian, Bowen Lin, Hui Yu   +3 more
doaj   +1 more source