Results 111 to 120 of about 34,497 (254)
, 2018 Currently, cardiovascular diseases are the leading cause of global mortality, while diabetes mellitus remains an important cause of cardiovascular morbidity.
Anna Ivanova (6059813)
core +1 more source
Pathogenesis of hidradenitis suppurativa: From susceptibility to chronicity
Journal of the European Academy of Dermatology and Venereology, EarlyView.This review describes hidradenitis suppurativa as a heterogeneous disorder in which genetic susceptibility, epithelial dysfunction, environmental exposures, immune activation and microbial ecology converge differently across patients and disease stages.
Kelsey R. van Straalen +5 more
wiley +1 more source
Journal of Internal Medicine, EarlyView.Abstract Background Evidence from randomized controlled trials (RCTs) testing medication reviews in geriatric oncology is sparse. Methods We conducted a single‐blinded RCT in ten rehabilitation clinics across Germany. Patients with common cancers, aged ≥ 65 years, and polypharmacy (regularly ≥ five drugs) were randomly allocated in equal proportions to
Miriam Degen +15 more
wiley +1 more source
The Goldilocks Principle in Neonatal Fluids: Finding the Just‐Right Balance
Journal of Paediatrics and Child Health, EarlyView.ABSTRACT The impact of disrupted fluid balance on outcomes in critically unwell children and adults is well described. Recent literature in neonates has demonstrated that both fluid overload and excessive postnatal fluid losses are associated with increased morbidity and mortality.
Jane B. McMahon +7 more
wiley +1 more source
Advanced Conduction Disease After Incident Heart Failure in Myotonic Dystrophy Type 1
Pacing and Clinical Electrophysiology, EarlyView.Central Figure. Advanced Conduction Disease After Incident HF in Myotonic Dystrophy Type 1. ABSTRACT Background Myotonic dystrophy type 1 (DM1) is associated with progressive cardiac conduction disease, heart failure (HF) and increased mortality. However, the association of incident HF with conduction disease and survival in DM1 is not well defined ...
Isadora Guarino +3 more
wiley +1 more source
Understanding Exosomes in Hair Regeneration
Periodontology 2000, EarlyView.Abstract Background Alopecia is a prevalent condition correlated with significant psychosocial challenges, while contemporary treatments exhibit variable efficacy, require extended use, and may cause adverse effects. This review aimed to comprehensively assess exosome‐mediated interventions as a novel cell‐free regenerative approach for hair ...
Paras Ahmad +3 more
wiley +1 more source
Endocrinology, Diabetes & MetabolismBackground Adding spironolactone to renin‐angiotensin‐aldosterone system (RAAS) blockers has been shown to reduce albuminuria in patients with diabetic kidney disease (DKD). However, the increased risk of hyperkalaemia is a major concern.
Manochehr Amini +5 more
doaj +1 more source
Spironolactone treatment for aortic valve regurgitation
, 2012 BACKGROUND AND AIM OF THE STUDY : Aortic regurgitation (AR) is a disease for which there is currently no effective medical treatment. It has been shown previously in an experimental model of AR that the renin-angiotensin-aldosterone system (RAAS) plays ...
Roussel, Élise +4 more
core
Effect of spironolactone on glucocorticoid-induced colonic cation transport
, 1988 Glucocorticoids stimulate colonic sodium absorption. Whether this stimulation is mediated by crossover binding to the aldosterone receptor has not been established.
C. P. Bastl
core +1 more source
Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes
The Journal of Physiology, EarlyView.Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière +6 more
wiley +1 more source