Results 91 to 100 of about 27,289 (199)

Spotlight on Spironolactone Oral Suspension for the Treatment of Heart Failure: Focus on Patient Selection and Perspectives

Vascular Health and Risk Management, 2019
Antonis A Manolis,1 Theodora A Manolis,2 Helen Melita,3 Antonis S Manolis4 1Patras University School of Medicine, Patras, Greece; 2Red Cross Hospital, Athens, Greece; 3Onassis Cardiac Surgery Center, Athens, Greece; 4Athens University School of Medicine,
Manolis AA, Manolis TA, Melita H, Manolis AS   +3 more
doaj  

Exploring Risks of Adverse Drug Events From Single Drug to Three‐Drug Combination

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Use of three‐drug combinations is common and could increase the risk of adverse drug events (ADEs). Signals of ADEs from three‐drug combinations could be identified from real‐world data, and the risks of ADEs from single drug exposure to three‐drug combination exposure could be illustrated by a graphic model.
Yi Shi, Anna Sun, Chien‐Wei Chiang, Yuedi Yang, Katherine M. Hunold, Jing Xu, Mu Shan, Allison Lu, Massimiliano Russo, Jeffrey M. Caterino, Michael T. Eadon, Lang Li, Jing Su, Macarius Donneyong, Pengyue Zhang   +14 more
wiley   +1 more source

The Effects of Combined Antihypertensive and Antidiabetic Therapies on Cardiovascular Outcomes: A Systematic Review and Meta‐Analysis

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6874-6887, August 2026.
ABSTRACT Aims Hypertension and diabetes frequently coexist, yet the net clinical impact of intentionally combining antihypertensive (AHTN) and antidiabetic (ADA) therapies on cardiovascular (CV) outcomes is uncertain. Here we quantified the effects of AHTN and ADA co‐therapy on CV and blood pressure (BP)/heart rate (HR) outcomes.
Wan Chin Hsieh, Brandon Michael Henry, István Édes   +2 more
wiley   +1 more source

Left Atrial Coupling Indexes as New Mortality Predictors in Chronic Chagas Disease

Echocardiography, Volume 43, Issue 8, August 2026.
Echocardiographic left atrial coupling indexes are promising prognostic markers of dismal outcome in Chagas disease. They were associated with all‐cause mortality independent from age, sex, and echocardiographic indexes, including LV ejection fraction, supporting their potential clinical relevance.
Roberto M. Saraiva, Mauro Felippe F. Mediano, Henrique H. Veloso, Marcelo T. Holanda, Andréa R. Costa   +4 more
wiley   +1 more source

The Six R's of Management Reasoning for Subintern Education

The Clinical Teacher, Volume 23, Issue 4, August 2026.
ABSTRACT Background Management reasoning (MR), the component of clinical reasoning concerned with treatment planning, patient preferences and resource considerations, develops later than diagnostic reasoning and remains underemphasised in medical education. Despite calls to explicitly teach MR, instructional strategies remain scarce.
Maria Maldonado, Peter Boedeker, Anita V. Kusnoor   +2 more
wiley   +1 more source

Epoxidation of Cashmeran and Unprecedented Rearrangement to an α‐Carbonyl δ‐Spirolactone

European Journal of Organic Chemistry, Volume 29, Issue 28, 25 July 2026.
A new strategy enables diastereoselective conversion of Cashmeran into a previously unknown α‐carbonyl δ‐spirolactone via epoxidation, Baeyer–Villiger oxidation, and acid‐catalyzed rearrangement. Structure and mechanism were confirmed by NMR, single crystal X‐ray diffraction, and computational studies. We report the epoxidation of Cashmeran followed by
Lukas Kell, Niklas Bartsch, Johannes Panten, Marcus Eh, Jan Paradies, Hans Egold, Anke Spannenberg, Thomas Werner   +7 more
wiley   +1 more source

Intermittent Fasting Exerts Antidepressant‐Like Effects by Restoring HPA Axis Homeostasis Through Coordinated GR–MR Signaling

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Intermittent fasting (IF) exerts antidepressant‐like effects by restoring impaired cooperative signaling between glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), thereby modulating hypothalamic neurocircuit activity and reinstating HPA axis homeostasis.
Miaomiao Tang, Qihan Sun, Jinfang Song, Xinmiao Piao, Zihui Geng, Xu Han, Runxin Li, Yue Li, Mengyi Han, Ranji Cui, Bingjin Li   +10 more
wiley   +1 more source

Improving the dissolution properties of spironolactone using liquisolid technique

Pharmaceutical and Biomedical Research, 2015
In this study the effect of liquisolid technique on the dissolution profile of spironolactone was evaluated. Different formulations of spironolactone liquisolid compacts were prepared using various amounts of non-volatile vehicles (Poly ethylene glycol ...
Jafar Akbari, Majid Saeedi, Katayoun Morteza-Semnani, Zaynab Sadeghi Ghadi, Seyed Saeed Hosseini   +4 more
doaj  

Effect of Diuretics on Cutaneous Squamous Cell Carcinoma: Clinical and Translational Evidence

International Journal of Dermatology, Volume 65, Issue 8, Page 1698-1700, August 2026.
Kevin Sheng‐Kai Ma, Stefano Sol, Fabiana Boncimino, Serena Yun‐Chen Tsai, Bethany J. Brumbaugh, Anna Mandinova, Steven T. Chen   +6 more
wiley   +1 more source

Antagonizing NRG1-ERBB4 signaling pathway with spironolactone for the treatment of schizophrenia: results of a randomized controlled drug repositioning clinical trial. [PDF]

Commun Med (Lond)
Hasan A, Leucht S, Roeh A, Langguth B, Hansbauer M, Oviedo-Salcedo T, Greiner SK, Papazova I, Löhrs L, Maurus I, Strube W, Rossner MJ, Wehr MC, Bauer I, Heres S, Kreuzer PM, Zimmermann S, Schneider-Axmann T, Görlitz T, Baumgartner A, Karch S, Egert-Schwender S, Blankenstein C, Rothe P, Wagner E, Aminifarsani Z, Downie B, Leucht C, Falkai P.   +28 more
europepmc   +1 more source