Spironolactone - Open Access .click

Expert Opinion on Investigational Drugs, 2001
Until recently, spironolactone was considered only as an antagonist at the aldosterone receptors of the epithelial cells of the kidney and was used clinically in the treatment of hyperaldosteronism and, occasionally, as a K(+)-sparing diuretic. The spironolactone renaissance started with the experimental finding that spironolactone reversed aldosterone-
Lindsay Brown, S A Doggrell
exaly +6 more sources

Spironolactone in dermatology

Dermatologic Therapy, 2022
Spironolactone is a drug, similar in structure to aldosterone and acts as an aldosterone receptor antagonist with an anti-androgenic effect. This drug has proven to be useful in several dermatological entities, however its use has not been well explored.
Diana Alejandra, Aguilar Medina, Jorge, Cazarín, Mario, Magaña +2 more
openaire +2 more sources

Novel spironolactone-analogs as impurities in spironolactone

Steroids, 2004
Six novel spironolactone-analogs steroids (3-8) were isolated from spironolactone by using various chromatographic methods. Their structures were elucidated by spectrometric analysis. Two of the analogs (3 and 7) were confirmed by X-ray crystallography.
Hua, Chen +3 more
openaire +2 more sources

humans
3. good health
heart failure

hypertension
dermatology
cardiac fibrosis

medicine
aldosterone
therapeutics