Results 141 to 150 of about 34,497 (254)

Heart Failure Progression in the Setting of Persistent Atrial Fibrillation, Frequent Premature Ventricular Complexes, and Malignancy‐Related Limitations to Guideline‐Directed Medical Therapy: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
Persistent atrial fibrillation, frequent premature ventricular complexes, and limited tolerance of guideline‐directed medical therapy contributed to progressive ventricular dysfunction, with LVEF declining from approximately 50% to 20%–25%. AV nodal ablation with CRT‐D implantation provided durable ventricular rate control and biventricular pacing.
Douni Roger, Waleed Shaker, Majid Yavari, Rajan Thakur, Mark Castellani, Zan Siddiqi, Maurice Tiotsop   +6 more
wiley   +1 more source

Improving the dissolution properties of spironolactone using liquisolid technique

Pharmaceutical and Biomedical Research, 2015
In this study the effect of liquisolid technique on the dissolution profile of spironolactone was evaluated. Different formulations of spironolactone liquisolid compacts were prepared using various amounts of non-volatile vehicles (Poly ethylene glycol ...
Jafar Akbari, Majid Saeedi, Katayoun Morteza-Semnani, Zaynab Sadeghi Ghadi, Seyed Saeed Hosseini   +4 more
doaj  

Assessment of Potential Drug‐Drug Interactions in Hospitalized Patients With Cardiovascular Diseases at Kenyatta National Hospital, Nairobi, Kenya: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aim Drug–drug interactions (DDIs) occur when the pharmacological effect of one medication is altered by the concurrent administration of another, potentially leading to reduced therapeutic efficacy or increased risk of adverse effects.
Brenda Koech, Ermias Terefe
wiley   +1 more source

Appropriate ICD Therapies in Primary Prevention: A Propensity‐Matched Comparison of Contemporary and Historic Heart Failure Cohorts

Journal of Arrhythmia, Volume 42, Issue 5, October 2026.
No significant difference in appropriate ICD therapies between treatment eras. Time to first ICD therapy was similar after propensity‐score matching. The result was robust to a sensitivity analysis using an expanded propensity model. Cumulative incidence, accounting for competing risk of death, was also higher.
Inês Ferreira Neves, Guilherme Portugal, Julien Lopes, Ana Rita Teixeira, Pedro Silva Cunha, Bruno Valente, Ana Lousinha, Rita Moreira, Hélder Santos, António Gonçalves, Rui Cruz Ferreira, Mário Martins Oliveira   +11 more
wiley   +1 more source

Brain Penetrant Calcium Channel Blockers Were Not Associated With Reduced Alcohol Consumption: Converging Results From Two Large Independent Cohort Studies Using Electronic Health Records

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 10, October 2026.
ABSTRACT Purpose Alcohol use disorder (AUD) remains a major public health problem, with few effective treatments. L‐type calcium channel blockers (LTCCBs) have genetic and preclinical support as potential treatments for AUD. Methods We evaluated whether brain penetrant (BP)‐LTCCBs are associated with reduced alcohol consumption in two preregistered ...
Christopher T. Rentsch, Vanessa A. Palzes, Mingjian Shi, Michael R. Setzer, Samantha G. Malone, Andrea H. Kline‐Simon, Emma L. Winterlind, Lorenzo Leggio, Vincent Lo Re III, David A. Fiellin, John Tazare, Mehdi Farokhnia, Stacy Sterling, Henry R. Kranzler, Joshua C. Gray   +14 more
wiley   +1 more source

An App‐Based Proton Pump Inhibitor Discontinuation Tool: A Multicentre, Open‐Label, Randomised Superiority Trial

United European Gastroenterology Journal, Volume 14, Issue 8, October 2026.
ABSTRACT Background Proton pump inhibitors (PPIs) are frequently used without long‐term indication. Discontinuation remains challenging because of rebound symptoms. Whether digital guidance tools improve discontinuation is unknown. We evaluated whether an app improves PPI discontinuation.
Lieke M. Koggel, Thomas Timmers, Marten A. Lantinga, Rudolf B. Kool, Cornelis Kramers, Noortje van Herwaarden, Peter D. Siersema, on behalf of the SUPPORT study consortium, B. A. J. Veldman, A. C. I. T. L. Tan, L. B. Hilbrands, I. L. Meek   +11 more
wiley   +1 more source

Muscle Strength and Power Changes With Gender‐Affirming Hormone Therapy

Andrology, Volume 14, Issue 7, Page 2138-2149, October 2026.
ABSTRACT Background Androgen receptors are highly expressed in upper body muscles, but changes in maximal muscle strength and power in major upper body muscles have not been investigated during gender‐affirming hormone therapy (GAHT). Objective To assess prospective changes in maximal muscle strength and muscle power from before and after 1 year of ...
Mathilde Kamp Nørlund, Jakob Lindberg Nielsen, Marianne Skovsager Andersen, Rikke Hjortebjerg, Laust Frisenberg Buhl, Anne Pernille Hermann, Camilla Viola Buskbjerg Palm, Tine Taulbjerg Kristensen, Jan Frystyk, Per Aagaard, Jonas Mathiesen, Dorte Glintborg, Louise Lehmann Christensen   +12 more
wiley   +1 more source

Oral and Topical Spironolactone in Adult Female Acne: A Narrative Review Comparing Systemic and Local Approaches. [PDF]

Clin Cosmet Investig Dermatol
Łyko M, Złotowska A, Jankowska-Konsur A.   +2 more
europepmc   +1 more source

Improving Medication Safety Following Neonatal Discharge: A Feasibility Study of a Parent Medication Education Intervention in Ireland

Acta Paediatrica, Volume 115, Issue 10, Page 2191-2199, October 2026.
ABSTRACT Aim Neonates discharged home on medications remain at risk of medication errors. The PADDINGToN programme previously developed parent co‐designed resources to support safer medication administration following discharge. The aim of this study, PADDINGToN‐2, is to evaluate the feasibility of recruiting and retaining parents in a study assessing ...
S. Giva, B. Cleary, F. Gaffney, L. Bracken, A. Gill, C. Sutton, J. Clark, V. Gray, N. McCallion, F. O'Brien   +9 more
wiley   +1 more source

A Distinct Immune Signature Characterizes Cirrhosis in Ethiopian Individuals With Chronic HBV Infection

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 7, Page 951-964, October 2026.
Cirrhosis patients with untreated HBV in Ethiopia exhibit a distinct immune profile marked by depletion of NK cells, B cells, and T cells, alongside an expanded CD38+HLA‐DR+ CD8 T‐cell population. ABSTRACT Background and Aims The immune cell phenotype of African patients living with chronic hepatitis B virus (HBV) infection is rarely described, despite
Julia MacLeod, Fikadu G. Gudissa, Asiya Jeylan, Nega Berhe, Hailemichael Desalegn, Lasse Rossvoll, Asgeir Johannessen, Niklas K. Björkström, Dag Henrik Reikvam, Annika Niehrs   +9 more
wiley   +1 more source